Article type: Research Article
Authors: Tulloch-Reid, M.K.a; * | Boyne, M.S.a | Choo-Kang, E.G.b | Parkes, R.H.c | Wright-Pascoe, R.A.d | Barton, E.N.d | Wilks, R.J.a | Palmer-Levy, M.L.e | Smikle, M.F.e
Affiliations: [a] The Tropical Medicine Research Institute, The University of the West Indies, Mona, Jamaica | [b] Department of Pathology, The University of the West Indies, Mona, Jamaica | [c] The Department of Medicine, Kingston Public Hospital, Kingston, Jamaica | [d] The Department of Medicine, The University of the West Indies, Mona, Jamaica | [e] Department of Microbiology, The University of the West Indies, Mona, Jamaica
Correspondence:
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Corresponding author: Marshall Tulloch-Reid, MBBS, MPhil, DSc, FACE, Lecturer in Epidemiology, Epidemiology Research Unit, TMRI, The University of the West Indies, Mona, Kingston 7, Jamaica, WI. Tel.: +1 876 927 2471; Fax: +1 876 927 2984; E-mail: [email protected].
Abstract: The prevalence of diabetes and other autoantibodies in patients with recently diagnosed youth onset diabetes was evaluated. Fifty-seven patients (95% black, age 19 ± 5 years, 36% male, diabetes duration 2.6 ± 2.2 years) were clinically diagnosed as having type 1 (n = 35), type 2 (n = 13) and lipoatrophic diabetes (n = 3) while 6 remained untyped. GAD65 was the most common diabetes-associated autoantibody in patients with type 1A diabetes (12/17; 71%). The prevalence of any diabetes-associated autoantibodies decreased with diabetes duration (OR[95%CI]/yr after diagnosis 0.50[0.31,0.82]) and was not associated with age of onset, duration or gender. Rheumatoid factor (13/57; 23%), smooth muscle (6/57; 11%), gastric-parietal cell (5/57; 9%) and thyroid microsomal antibodies (5/57; 9%) were the most frequent non-diabetes associated autoantibodies and were more common in patients with type 1A diabetes. Only one patient had clinical autoimmune disease (hypothyroidism). Type 1A diabetes may constitute up to half the cases of newly diagnosed type 1 diabetes in Jamaican youth and is associated with a higher prevalence of other organ-specific autoantibodies.
Keywords: Type 1 diabetes, autoimmunity, GAD antibodies, IA2 antibodies, ICA antibodies, black population, developing countries
DOI: 10.3233/HAB-2008-173-402
Journal: Human Antibodies, vol. 17, no. 3-4, pp. 57-62, 2008
Published: 12 November 2008
