Affiliations: Departments of Pathology and Medical Genetics, Haartman Institute and Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland | Department of Pathology, University of Ulsan, College of Medicine, ASAN Medical Center, Seoul, South Korea | Department of General Surgery, University of Ulsan, College of Medicine, ASAN Medical Center, Seoul, South Korea | Department of Diagnostic Radiology, University of Ulsan, College of Medicine, ASAN Medical Center, Seoul, South Korea
Note: [] Equal contribution (K.J. Jee and G. Gong.).
Note: [] Equal contribution (K.J. Jee and G. Gong.)
Note: [] Corresponding author: Sakari Knuutila, Departments of Pathology and Medical Genetics, Haartman Institute, POB 21 (Haartmaninkatu 3), FIN‐00014 University of Helsinki, Helsinki, Finland. Tel.: +358 9 191 26527; Fax: +358 9 191 26788; E‐mail: [email protected].
Abstract: We studied DNA copy number changes by CGH and allelic imbalance (AI) on 3p by LOH analysis on 22 phyllodes tumours (PT) of the breast in order to gain insight into the genetic basis of tumour progression in PT. Copy number changes were observed in 14 cases (63%). Gain in 1q with 1q21–23 as the minimal overlapping area was seen in 12 cases (55%). The gain was observed both in benign and malignant tumours. Our study did not reveal any DNA copy number changes or allelic loss on 3p. The results suggest that DNA copy number changes are not associated with the histological grade or clinical behaviour of PT and the chromosomal changes on 3p appear to be rare. Colour figure can be viewed on http://www.esacp.org/acp/2003/25‐2/jee.htm
Keywords: Phyllodes tumour, comparative genomic hybridization, allelic loss on 3p, chromosome 1q21–q23
