International Journal of Risk & Safety in Medicine - Volume 9, issue 1

Article Type: Other

DOI: 10.3233/JRS-1996-9101

Citation: International Journal of Risk and Safety in Medicine, vol. 9, no. 1, pp. 1-6, 1996

Authors: Kales, Anthony | Vgontzas, Alexandros N. | Bixler, Edward O.

Article Type: Research Article

Abstract: Concern over the safety of triazolam is reflected in the actions taken against the drug world-wide by many drug regulatory agencies, ranging from restrictions in duration of use and dosage to banning of the drug. There is extensive scientific literature documenting that triazolam produces frequent and severe psychiatric adverse events: during drug administration these include memory impairment/amnesia and other cognitive impairments and daytime anxiety states and early morning insomnia; following drug withdrawal there can be a marked worsening of sleep (rebound insomnia). It is difficult to improve triazolam's benefit-to-risk ratio either by lowering the dose or by short and …intermittent use. The 0.5 mg and 1.0 mg doses of triazolam are effective, but produce severe psychiatric adverse events while the 0.25 mg dose has limited efficacy while still being associated with frequent adverse events. Moreover, many of triazolam's adverse events are associated with the first (or first several) doses used, and rebound insomnia often occurs on withdrawal even after only one night of use. Show more

DOI: 10.3233/JRS-1996-9102

Citation: International Journal of Risk and Safety in Medicine, vol. 9, no. 1, pp. 7-27, 1996

Authors: Levi, N. | Jensen, L.P. | Schroeder, T.V.

Article Type: Research Article

Abstract: The accuracy of data contained in the Danish vascular database was compared with the case notes. A total of 100 case notes were reviewed for 11 pertinent variables in the database. A high error rate ranging from 2 to 34% was found. Also, approximately 10% of patients had never been entered into the vascular database. Further improvement of the Danish vascular database is necessary for its use as basis for reporting results.

DOI: 10.3233/JRS-1996-9103

Citation: International Journal of Risk and Safety in Medicine, vol. 9, no. 1, pp. 29-31, 1996

Authors: Sammut, Michael | Savona-Ventura, Charles

Article Type: Research Article

Abstract: The Maltese population has been repeatedly shown to have high mean blood lead levels irrespective of age. This study confirms that these higher levels also occur in Maltese children. A definite correlation is shown between high blood lead levels and the environment of the subjects studied, being statistically higher in individuals living on the urbanized larger island. A statistical correlation has been shown between hand-wipe specimens taken from children playing in a playground and the traffic density of the area. A similar statistical correlation between playground, street and household dust to traffic density has also been identified.

Keywords: Lead, traffic-density, environment

DOI: 10.3233/JRS-1996-9104

Citation: International Journal of Risk and Safety in Medicine, vol. 9, no. 1, pp. 33-40, 1996

Authors: Dukes, M.N.G.

Article Type: Other

Abstract: Eleven plaintiffs vs. The United Kingdom Medical Research Council (First Defendant) and the Secretary of State of Health (Second Defendant). High Court of Justice, Queen's Bench Division, No. 1994-N-06806. Judgement by Mr. Justice Morland, London; unrevised text, July 24th, 1996.

Keywords: Human Growth Hormone, contamination, Creutzfeldt-Jakob disease, negligence, liability of the state, emergent knowledge

DOI: 10.3233/JRS-1996-9105

Citation: International Journal of Risk and Safety in Medicine, vol. 9, no. 1, pp. 41-46, 1996

Article Type: Review Article

DOI: 10.3233/JRS-1996-9106

Citation: International Journal of Risk and Safety in Medicine, vol. 9, no. 1, pp. 47-59, 1996

Article Type: Book Review

DOI: 10.3233/JRS-1996-9107

Citation: International Journal of Risk and Safety in Medicine, vol. 9, no. 1, pp. 61-64, 1996

Article Type: Other

DOI: 10.3233/JRS-1996-9108

Citation: International Journal of Risk and Safety in Medicine, vol. 9, no. 1, pp. 65-69, 1996