International Journal of Risk & Safety in Medicine - Volume 3, issue 3

Article Type: Review Article

DOI: 10.3233/JRS-1992-3301

Citation: International Journal of Risk and Safety in Medicine, vol. 3, no. 3, pp. 119-128, 1992

Authors: ten Kate, Leo P. | Cornel, Martina C. | de Walle, Hermien E.K.

Article Type: Research Article

Abstract: Since the thalidomide disaster in the early sixties many birth defect monitoring systems and registries have been set up to detect changes in the frequencies of specific birth defects. The primary methods of monitoring have been the statistical analysis of data on birth prevalences and teratologic analysis. The yield of this monitoring effect has nevertheless been low when one considers the lack of etiologic factors detected in this way. We therefore propose an additional strategy involving (periodic) classification of all cases in a birth defect registry according to possible risk factors and notified anomalies coupled with a search for specific …associations between risk factors and (patterns of) anomalies. We here present data showing the sensitivity of the method. Sensitivity was studied by looking at some already well known associations between risk factors and congenital anomalies in our registry involving 1850 cases. The associations studied were neural tube defects and maternal use of valproic acid, numerical chromosomal anomalies and advanced maternal age, gastroschisis and low maternal age, and autosomal recessive disorders and parental consanguinity. Each of these associations was apparent in the registry, suggesting that risk factor/outcome monitoring as described here is a potentially strong method for finding new etiologic factors in birth defects. Show more

Keywords: Monitoring, Birth defects, Registries, Risk factors, Outcome

DOI: 10.3233/JRS-1992-3302

Citation: International Journal of Risk and Safety in Medicine, vol. 3, no. 3, pp. 129-136, 1992

Authors: Kimbel, Karl H.

Article Type: Other

DOI: 10.3233/JRS-1992-3303

Citation: International Journal of Risk and Safety in Medicine, vol. 3, no. 3, pp. 137-138, 1992

Article Type: Other

DOI: 10.3233/JRS-1992-3304

Citation: International Journal of Risk and Safety in Medicine, vol. 3, no. 3, pp. 139-141, 1992

Authors: Kalix, Peter

Article Type: Research Article

Abstract: Since ancient times, the khat bush has been grown in certain areas of East Africa and of the Arab Peninsula, and many people chew its leaves because of their stimulating effect. As khat use may be compulsive, the habit has been seen as a phenomenon of drug addiction, indeed, khat is known to induce a certain degree of psychic dependence and to contain an alkaloid with amphetamine effects. Due to the availability of air transport, this drug has now made its appearance in Western Europe and in the USA. This is worrying because khat consumption may induce toxic psychosis, several …such cases have recently been observed in Great Britain. The present article therefore describes the habit and the effects of chewing khat, and it provides some background information together with a discussion of the advisability of prohibitive measures regarding this drug. Show more

Keywords: Khat, Stimulant, Drug habit

DOI: 10.3233/JRS-1992-3305

Citation: International Journal of Risk and Safety in Medicine, vol. 3, no. 3, pp. 143-156, 1992

Authors: David, Judith

Article Type: Other

DOI: 10.3233/JRS-1992-3306

Citation: International Journal of Risk and Safety in Medicine, vol. 3, no. 3, pp. 157-160, 1992

Authors: van Weel, C.

Article Type: Other

DOI: 10.3233/JRS-1992-3307

Citation: International Journal of Risk and Safety in Medicine, vol. 3, no. 3, pp. 161-162, 1992

Authors: Curran, William J.

Article Type: Other

DOI: 10.3233/JRS-1992-3308

Citation: International Journal of Risk and Safety in Medicine, vol. 3, no. 3, pp. 163-166, 1992

Article Type: Book Review

DOI: 10.3233/JRS-1992-3309

Citation: International Journal of Risk and Safety in Medicine, vol. 3, no. 3, pp. 167-170, 1992

Article Type: Other

DOI: 10.3233/JRS-1992-3310

Citation: International Journal of Risk and Safety in Medicine, vol. 3, no. 3, pp. 171-172, 1992