International Journal of Risk & Safety in Medicine - Volume 12, issue 1 - Journals

Why don’t we turn medical education back to front?

Article Type: Other

Citation: International Journal of Risk and Safety in Medicine, vol. 12, no. 1, pp. 1-2, 1999

Psychostimulants in the treatment of children diagnosed with ADHD: Risks and mechanism of action

Article Type: Research Article

Abstract: Millions of children in North America are diagnosed with attention deficit/hyperactivity disorder and treated with psychostimulants such as methylphenidate, dextroamphetamine, and methamphetamine. These drugs produce a continuum of central nervous system toxicity that begins with increased energy, hyperalertness, and overfocusing on rote activities. It progresses toward obsessive/compulsive or perseverative activities, insomnia, agitation, hypomania, mania, and sometimes seizures. They also commonly result in apathy, social withdrawal, emotional depression, and docility. Psychostimulants also cause physical withdrawal, including rebound and dependence. They inhibit growth, and produce various cerebral dysfunctions, some of which can become irreversible. The “therapeutic” effects of stimulants are a …direct expression of their toxicity. Animal and human research indicates that these drugs often suppress spontaneous and social behaviors while promoting obsessive/compulsive behaviors. These adverse drug effects make the psychostimulants seemingly useful for controlling the behavior of children, especially in highly structured environments that do not attend to their genuine needs. Show more

Citation: International Journal of Risk and Safety in Medicine, vol. 12, no. 1, pp. 3-35, 1999

Price: EUR 27.50

What is really known about psychological alterations produced by psychiatric drugs?

Authors: Jacobs, David | Cohen, David

Article Type: Research Article

Abstract: This paper argues that information about psychiatric drugs derived from conventionally conducted randomized controlled clinical trials (RCTs) is inadequate to form an accurate picture of drug‐induced psychological alterations. Two main lines of argument are presented. The first concerns the disparity between adverse effects established in RCTs and the broader range of adverse drug reaction reports which derive from non‐RCT formats. The second concerns the contention that information about drug‐induced psychological alterations obtained from RCTs is too limited to address the meaning of observed “target symptom” reduction which occurs during the course of the (typically very brief) investigation. The paper considers …the possibility that nominal “therapeutic” drug effects may only be part of a larger, inadequately discerned picture of drug‐induced psychological toxicity. Show more

Citation: International Journal of Risk and Safety in Medicine, vol. 12, no. 1, pp. 37-47, 1999

Price: EUR 27.50

Article Type: Other

Citation: International Journal of Risk and Safety in Medicine, vol. 12, no. 1, pp. 79-80, 1999

Get PDF

North America

IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA

Tel: +1 703 830 6300
Fax: +1 703 830 2300
[email protected]

For editorial issues, like the status of your submitted paper or proposals, write to [email protected]

Europe

IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands

Tel: +31 20 688 3355
Fax: +31 20 687 0091
[email protected]

For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office [email protected]

Asia

Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China

Free service line: 400 661 8717
Fax: +86 10 8446 7947
[email protected]

For editorial issues, like the status of your submitted paper or proposals, write to [email protected]

如果您在出版方面需要帮助或有任何建, 件至: [email protected]