Human Antibodies - Volume Pre-press, issue Pre-press

Authors: Al-Nasralla, Azhar S.H. | Hussian, Suzan Saadi | Tektook, Nihad Khalawe

Article Type: Research Article

Abstract: INTRODUCTION: Among the cancers that impacts men, prostate cancer considerably raises deaths for males around the world. Persons with tumours can have a localized or advanced form of the illness. OBJECTIVE: The present study aimed to determining the relationship between the level of cytokines (IL-10 and TNF-a) and PSA in the sera of patients and compared it with healthy. MATERIALS AND METHODS: A case control study consist of three group included was in this study. The first group involves 50 patients with PC were observation in Al-Amal Oncology Hospital in the period …from April 2021 to April 2022 under the supervision of oncology specialists was included in this study. Second group consist of 30 patients. They have benign hyper plaisa (BHP), this group has been collected from urosergical department . Third group was include 20 healthy volunteers (non prostate cancer and non BHP). Prostate specific antigen (PSA) was measured by mini – VIDAS device using kit supplied by Biomerieux – France. IL-10 and TNF-a levels were measured by ELISA technique using kit supplied by CAUSABIO – China. RESULTS: Results of the present study showed the 60–69 years age group scored highest percentage in benign (56.7%), malignant (54.0%), compared to control (healthy) (50.0%), while > 69 years scored least percentage in these groups (3.3%, 14.0%, and 25.0%) respectively with significant different (p < 0.05). Additionally, the IL-10 and PSA scored highest mean levels in the malignant group (1.22 ± 0.23 and 27.66 ± 6.31), while TNF-a scored highest mean levels in a benign group (0.30 ± 0.11). The least mean level of IL-10 was in healthy (0.42 ± 0.15), TNF-a in malignant (0.23 ± 0.03), and PSA in benign (6.73 ± 1.36). Finally, there is a significant difference among age groups and PSA, IL-10, and TNF-parameters. CONCLUSIONS: We concluded the PSA, TNF-a and IL-10 parameters are play important roles in pathogenesis patients with prostate cancer. PCa is high prevalence in elderly population. Show more

Keywords: Prostate cancer, PSA, IL-10, TNF-a

DOI: 10.3233/HAB-220018

Citation: Human Antibodies, vol. Pre-press, no. Pre-press, pp. 1-9, 2023

Authors: Cagan, Murat | Donmez, Hanife Guler | Dikmen, Zeliha Gunnur | Beksac, Mehmet Sinan

Article Type: Research Article

Abstract: BACKGROUND: Lupus anticoagulant (LA) may be a cause of poor obstetric outcome. OBJECTIVE: To search the association of LA with risk factors for obstetric complications and adverse gestational outcome. METHODS: This retrospective cohort was consisted of 2 groups of pregnancies with poor obstetric history; 1) LA (+ ) gestations (Study Group, n = 20) and 2) LA (- ) gestations (Control Group, 78). All patients were admitted to a special antenatal care program and were examined in terms of risk factors for thrombotic events, …placenta-related obstetric complications, and poor gestational outcomes. Patients were administered low-dose low-molecular-weight heparin (LMWH), low-dose salicylic acid and low-dose corticosteroid (if necessary) within the framework of a prophylaxis protocol in addition to their already existing medications. RESULTS: We have shown that adverse gestational outcome was 1.7-fold more frequent in LA (+ ) pregnancies with poor obstetric history (p = 0.039, 70% vs. 41%). Higher rates of autoimmune diseases and hereditary thrombophilia were observed among LA (+ ) patients compared to LA (- ) gestations (35% vs. 10.3%, p < 0.012 and 55% vs. 19.2%, p < 0.003, respectively). To identify the effectiveness of low-dose LMWH prophylaxis protocol, we compared gestational outcomes and demonstrated that the miscarriage rate was significantly decreased to half in current pregnancies compared to the previous gestations (73.6% vs. 35%, p = 0.003). CONCLUSIONS: Autoimmune diseases and hereditary thrombophilia are more frequent in LA (+ ) pregnancies, and these women are prone to obstetric problems. Low-dose LMWH and salicylic acid prophylaxis are critical in the management of LA (+ ) pregnant women. Show more

Keywords: Adverse gestational outcome, autoimmune disorders, hereditary thrombophilia, lupus anticoagulants, miscarriage, preterm birth

DOI: 10.3233/HAB-230003

Citation: Human Antibodies, vol. Pre-press, no. Pre-press, pp. 1-8, 2023

Authors: TV, Phu | Tran, Thu Thao | Hao, Huynh Trung | Hau, Nguyen Thi Hien | Jain, Nityanand | Reinis, Aigars

Article Type: Brief Report

Abstract: BACKGROUND: Postural Orthostatic Tachycardia Syndrome (POTS) is a common condition affecting more than 170 people per 100,000 population. However, POTS following COVID-19 vaccination remains a rare reporting in the medical literature. OBJECTIVE: We, herein, summarize and highlight the evidence that has been reported regarding POTS-like symptoms following COVID-19 vaccination. METHODS: We conducted a literature search and summarized the findings in the form of a narrative commentary. All types of publications (case reports/series, original articles, letters to editors, brief communications etc.) in English language were included. RESULTS: Whilst the exact pathogenetic …mechanism behind POTS is yet to elucidated, there has been increasing evidence pointing towards an autoimmune dysfunction. Females were found to be predominantly affected (72%) with age range from 17 years to 52 years. Additionally, it seems that POTS-like symptoms could be triggered after immunization with Pfizer- BioNTech, Moderna, and Oxford-AstraZeneca COVID-19 vaccines. The symptoms typically appear within the first week, depending upon previous exposure to the virus and presence of other systemic conditions. In some patients, the condition is self-resolving. However, in others, non-pharmacological interventions coupled with negative ionotropic medications can be used for symptomatic management of the patients. CONCLUSIONS: Timely diagnosis and proper treatment are quintessential for ensuring early alleviation (and in some cases complete resolution) of symptoms. Furthermore, there may be episodes of relapse. Overall prognosis of the new-onset POTS-like symptoms is difficult to predict based on current literature. Show more

Keywords: Autoimmunity, COVID-19, mRNA vaccine, POTS, SARS-COV-2

DOI: 10.3233/HAB-220013

Citation: Human Antibodies, vol. Pre-press, no. Pre-press, pp. 1-9, 2023