Biorheology - Volume 24, issue 2

Article Type: Editorial

DOI: 10.3233/BIR-1987-24221

Citation: Biorheology, vol. 24, no. 2, pp. I-III, 1987

Authors: Silberberg, Alex | Copley, Alfred L.

Article Type: Editorial

DOI: 10.3233/BIR-1987-24201

Citation: Biorheology, vol. 24, no. 2, pp. 87-87, 1987

Authors: Weiss, Leonard

Article Type: Research Article

Abstract: A metastasis is a cancer which is not in contiguity with the primary tumor from which it arose. The major clinical problem in many people with so-called “solid” cancers lies not in dealing with their primary lesion, but rather in dealing with the metastases generated from these lesions. This is dramatically shown by comparing the 5-year survival rates of patients with and without overt metastases at the time of diagnosis (Axtell, L.M., Asire, A.J. and Myers, M.H. (Eds.). Cancer Patient Survival Rep. No. 5 , DHEW Publ. No. (NIH) 77–992. Washington, D.C.: U.S. Gov. Print Office, 1976).

Keywords: Metastasis, cancer cells, microcirculation

DOI: 10.3233/BIR-1987-24202

Citation: Biorheology, vol. 24, no. 2, pp. 89-92, 1987

Authors: Recklies, Anneliese D.

Article Type: Research Article

Keywords: Invasion, Metastasis, Connective Tissue, Proteinases

DOI: 10.3233/BIR-1987-24203

Citation: Biorheology, vol. 24, no. 2, pp. 93-103, 1987

Authors: Weiss, Leonard

Article Type: Research Article

Abstract: The blood-stream is the major disseminative route for metastasizing cancer cells, and metastases are generated when the cancer “microemboli” are trapped in the microcirculation. However, most circulating cancer cells are rapidly destroyed shortly before and/or after arrest. Traditionally, destruction is attributed to the cellular or humoral response of the host defense systems. A novel, non-exclusive mechanism for cancer cell destruction has been proposed by Weiss and Dimitrov in which friction or adhesion between circulating cancer cells and capillary walls causes local vascular blockage, and the blood-pressure differentials normally existing over the entire length of a capillary are consequently applied over …the length of the cancer cell. In a simple model, this pressure differential is expected to cause expansion of the cancer cell membrane, resulting in increases in tension above a critical level, with consequent membrane rupture and cell death. In vivo and in vitro experimental tests of this hypothesis are outlined. Show more

Keywords: Microcirculation, metastasis, cancer cells, rheology

DOI: 10.3233/BIR-1987-24204

Citation: Biorheology, vol. 24, no. 2, pp. 105-115, 1987

Authors: Jain, R.K. | Ward-Hartley, K.A.

Article Type: Research Article

Abstract: Interactions of cancer cells with the microvasculature and the interstitium of non-malignant tissue were studied in a rabbit ear chamber preparation using intravital fluorescent microscopy. Injection of VX2 carcinoma cells into the auricular artery feeding the chamber led to mechanical entrapment, adhesion, and in some instances, extravasation of cancer cells. Implantation of VX2 cells in the interstitial space led to increases in the interstitial diffusion coefficients and the microvascular permeability. Our results are compared with those available in literature and directions for future research are pointed out.

Keywords: Vasculature, interstitial matrix, transport, cell deformability

DOI: 10.3233/BIR-1987-24205

Citation: Biorheology, vol. 24, no. 2, pp. 117-125, 1987

Authors: Honn, Kenneth V. | Steinert, Bruce W. | Onoda, James M. | Sloane, Bonnie F.

Article Type: Research Article

Keywords: Prostacyclin, platelets, metastasis, hemostatic, endothelial cells

DOI: 10.3233/BIR-1987-24206

Citation: Biorheology, vol. 24, no. 2, pp. 127-137, 1987

Authors: Schmid-Schönbein, Geert W.

Article Type: Research Article

Abstract: The transport of leukocytes in the microcirculation is specific for the type, size, and the rheological and adhesive properties, the microanatomy of the host organ, and the hemodynamics. The adhesion to the endothelium is determined largely by the degree of activation via chemotactic factors. Leukocyte motion differs from that of red cells or platelets in several respects. When granulocytes enter into capillaries, they are deformed just like red cells. Under normal flow conditions, the time to deform at the entry to capillaries is typically 1,000 times larger than for the red cell, leading to temporary obstruction of the capillaries. After …entry, granulocytes move with lower velocity than red cells which causes a cell train formation inside the capillary. At the venular side, the granulocyte is displaced from the center stream toward the endothelium by faster moving red cells. This process leads to systematic attachment of the granulocytes to the endothelium. At a reduced perfusion pressure or in the presence of locally elevated levels of chemotactic factors, the granulocytes may not be able to pass through the capillary network, which leads to microvascular obstruction. Organs with a narrow capillary network may thereby become filters for circulating granulocytes. This event is accompanied in many situations with damage to the host organ. Show more

Keywords: Leukocytes, microcirculation

DOI: 10.3233/BIR-1987-24207

Citation: Biorheology, vol. 24, no. 2, pp. 139-151, 1987

Authors: Dobashi, Toshiaki | Goto, Iliroshi | Sakanishi, Akio | Oka, Syoten

Article Type: Research Article

Abstract: We have measured volume fraction dependence of the sedimentation curve of swine erythrocytes in a physiological saline solution at 10°C, 20°C, 30°C and 40°C. The sedimentation curves were found to consist of initial constant velocity region and final plateau region at the lower temperatures of 10°C and 20°C. while modified S-shaped curves were observed at the higher temperatures of 30°C and 40°C. The volume fraction dependence of the initial slope ν of the sedimentation curve was fitted well to the following exponential type equation at all the temperatures: ν = ν s , exp …( 1 − H ) exp − ( BH + CH 2 ) where ν s , exp is the velocity in infinite dilution corresponding to the Stokes velocity and H is the volume fraction of erythrocytes. The volume fraction dependence of the relative velocity ν / ν s , exp was in close agreement with a semi-empirical equation derived for slurrys in the field of chemical engineering at the lower temperatures. while a small deviation between the observed and calculated curves was found at the higher temperatures. The volume fraction dependence of ν at 20°C was also analyzed on a theory recently developed by Oka. The explicit functional form of the medium up-flow factor ϕ (H) and the deformability factor f in the theory were determined using the experimental data. Show more

Keywords: Erythrocyte sedimentation rate, swine blood, volume fraction dependence, physiological saline solution

DOI: 10.3233/BIR-1987-24208

Citation: Biorheology, vol. 24, no. 2, pp. 153-162, 1987

Authors: Rogausch, H.

Article Type: Research Article

Abstract: Vasodilated guinea pig livers were perfused with normal erythrocytes and echinocytes suspended in isoviscous high- and low-molecular-weight dextran solutions. The relative flow resistance of these suspensions and the oxygen uptake of the livers were then determined. The relative flow resistance of the echinocytes that were suspended in high-molecular-weight dextran, however, was significantly higher than that of any other red cell suspension. The oxygen uptake was independent of the perfusion media. It is proposed that high-molecular-weight dextran induces echinocytes to attach to one another, and that this clumping together, and shape-transformation of red cells, hinders their flow in the vasodilated …liver. Show more

Keywords: erythrocytes, viscosity, liver perfusion, oxygen consumption, bile acids

DOI: 10.3233/BIR-1987-24209

Citation: Biorheology, vol. 24, no. 2, pp. 163-171, 1987