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Biorheology is an international interdisciplinary journal that publishes research on the deformation and flow properties of biological systems or materials. It is the aim of the editors and publishers of
Biorheology to bring together contributions from those working in various fields of biorheological research from all over the world. A diverse editorial board with broad international representation provides guidance and expertise in wide-ranging applications of rheological methods to biological systems and materials.
The aim of biorheological research is to determine and characterize the dynamics of physiological processes at all levels of organization. Manuscripts should report original theoretical and/or experimental research promoting the scientific and technological advances in a broad field that ranges from the rheology of macromolecules and macromolecular arrays to cell, tissue and organ rheology. In all these areas, the interrelationships of rheological properties of the systems or materials investigated and their structural and functional aspects are stressed.
The scope of papers solicited by
Biorheology extends to systems at different levels of organization that have never been studied before, or, if studied previously, have either never been analyzed in terms of their rheological properties or have not been studied from the point of view of the rheological matching between their structural and functional properties. This biorheological approach applies in particular to molecular studies where changes of physical properties and conformation are investigated without reference to how the process actually takes place, how the forces generated are matched to the properties of the structures and environment concerned, proper time scales, or what structures or strength of structures are required.
Biorheology invites papers in which such 'molecular biorheological' aspects, whether in animal or plant systems, are examined and discussed. While we emphasize the biorheology of physiological function in organs and systems, the biorheology of disease is of equal interest. Biorheological analyses of pathological processes and their clinical implications are encouraged, including basic clinical research on hemodynamics and hemorheology.
In keeping with the rapidly developing fields of mechanobiology and regenerative medicine,
Biorheology aims to include studies of the rheological aspects of these fields by focusing on the dynamics of mechanical stress formation and the response of biological materials at the molecular and cellular level resulting from fluid-solid interactions. With increasing focus on new applications of nanotechnology to biological systems, rheological studies of the behavior of biological materials in therapeutic or diagnostic medical devices operating at the micro and nano scales are most welcome.
Abstract: Stress relaxation analysis was used to measure mechanical properties of the cell wall. Although a pre-extension period is needed to give the initial stress or strain to a cell wall specimen in the experiments, studies reported in literature have assumed its length to be zero. Thus, the parameters obtained may not represent characteristic properties of the cell wall, which vary depending upon the pre-extension conditions. A mathematical formulation for stress relaxation with consideration for pre-extension was established by introducing a correction factor K in order to obtain parameters which represent characteristic mechanical properties of the cell wall. The validity…of this treatment was examined by comparing the calculated values with experimental data.
Abstract: The stress relaxation parameters T o , T m , b , and c vary depending upon the pre-extension rate when a cell wall specimen is stretched using a tensile tester. The effect of the pre-extension rate on the stress relaxation parameters of pea epidermal cell wall was investigated using a newly established equation. The change in the parameters due to the pre-extension rate can be corrected by the equation qualitatively and approximately quantitatively. The newly established equation appears to validly express the stress relaxation process with consideration for…the pre-extension rate and the parameters T o k , T m k , b k , c k and K in the equation seem to represent the characteristic mechanical properties of the cell wall, although the parameters T o , T m , b , and c are valid for practical use to analyze the auxin effect on the mechanical properties of the cell wall.
Abstract: When the cell wall of pea epidermis is extended and returned at a fixed rate, the stress-strain curves form a hysteresis loop. The mechanical properties of the pea epidermal cell wall in a constant rate experiment can be simulated by a model consisting of an infinite number of Maxwell elements and a single spring in parallel with them, as in stress relaxation experiments. The mathematical formulation for a constant rate experiment is closely related to that for a stress relaxation experiment through its constant parameters. In a constant rate experiment, auxin pretreatment increases strain at a small stress. The…effect of auxin on the stress-strain curve in the constant rate experiment is qualitatively and quantitatively reproduced well by the constant parameters representing the effect of auxin on the stress-time curve in the stress relaxation experiment.
Abstract: A study of blood and plasma viscosities and of aggregation of red cells in 125 patients with malignant melanoma indicated that patients who died subsequently of metastasis showed a significant elevation of plasma viscosity and of aggregation of red cells. Plots of plasma viscosity or of aggregation of red cells against the time interval between test and subsequent death showed significant and negative correlations. Plots of plasma viscosity against globulin level, and plots of aggregation of red cells against albumin/fibrinogen ratio, showed significant differences between slopes of linear regressions for the survivors and for the deceased group.
vol. 15, no. 2, pp. 99-110, 1978
Abstract: Platelet diffusivity in flowing blood was measured using data from a deposition experiment on a subendothelial surface in a laminar flow chamber with aid of a theoretical estimation of platelet flux based on Leveque equation. Values of diffusivity range between 0.3 and 3.5×10−7 cm2 sec−1 for shear rates varying between 50 and 550 sec−1 and for a series of hematocrits (20, 40, 60). A convective-diffusive theory of the enhancement of diffusivity due to red cell rotational motion is then developed to quantitatively analyse the dependence of diffusivity on both shear rate and hematocrit.
vol. 15, no. 2, pp. 111-117, 1978
Abstract: Viscosity of Poiseuille flow of a fluid with couple stress has been studied in this paper. The analytic expression of the viscosity of couple stress fluid has been obtained in the form of modified Bessel’s functions of the order of zero and one. Since it is a complicated function of the couple stress parameters α and η , the numerical values of the relative viscosity η r have been computed for various values of α and η . These theoretical results are compared with other theoretical and experimental results on blood flow…and suspension flows with 40% concentration. For the quick calculation of η r two simple approximate formulas have been obtained. The values of η r obtained from the exact formula and the approximate formulas are compared and it is found that they are in good agreement (within 6% error). The variation of η r (exact and approximate) with α and η is shown graphically which clearly indicates the existence of a discontinuity in the relative viscosity and the velocity at point (α = 0.0 and η = 1.0). The most important conclusions of this analysis are: (i) the conditions for the existence of Fahraeus-Lindquist effect in a tube flow have been obtained; (ii) Up to this date, only velocity profiles have been used to determine the values of α and η (η chosen arbitrarily); here it is shown that by using the experimental velocity profiles and relative viscosity both the couple stress parameters can be determine quite accurately (η no longer chosen arbitrarily). Finally, some biological implications of this theoretical investigation have been indicated.
vol. 15, no. 2, pp. 119-128, 1978