Estimation of platelet diffusivity in flowing blood

Article type: Research Article

Authors: Antonini, G.^{a; b} | Guiffant, G.^{a; b} | Quemada, D.^{a; b} | Dosne, A.M.^{a; b}

Affiliations: [a] LBHP, T.33/34, 2 Place Jussieu, Université de Paris, 75005, France | [b] Laboratoire d’Hémostase, and Hôpital Saint-Louis, Paris, 75010, France

Note: [] Accepted by: Editors-in-chief

Abstract: Platelet diffusivity in flowing blood was measured using data from a deposition experiment on a subendothelial surface in a laminar flow chamber with aid of a theoretical estimation of platelet flux based on Leveque equation. Values of diffusivity range between 0.3 and 3.5×10−7 cm2 sec−1 for shear rates varying between 50 and 550 sec−1 and for a series of hematocrits (20, 40, 60). A convective-diffusive theory of the enhancement of diffusivity due to red cell rotational motion is then developed to quantitatively analyse the dependence of diffusivity on both shear rate and hematocrit.

DOI: 10.3233/BIR-1978-15205

Journal: Biorheology, vol. 15, no. 2, pp. 111-117, 1978