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Issue title: Special Issue: Vaccines
Article type: Research Article
Authors: Marks, Donald H.
Affiliations: Department of Medicine, Cooper Green Mercy Hospital, Birmingham, AL, USA
Note: [] Address for correspondence: Donald H. Marks, MD, PhD, 9340 Helena Road, Suite F-414, Hoover, AL 35244, USA. Tel.: +1 435 487 3790; Fax: +1 435 487 3790; E-mail: [email protected]
Abstract: A wide range of neurological complications have been reported via the medical literature and the VAERS system after vaccination with recombinant outer surface protein A (OspA) of Borrelia. To explore this issue, 24 patients reporting neurological adverse events (AE) after vaccination with Lymerix, out of a group of 94 patients reporting adverse events after Lymerix vaccination, were examined for causation. Five reports of cerebral ischemia, two transient Ischemic attacks, five demyelinating events, two optic neuritis, two reports of transverse myelitis, and one non-specific demyelinating condition are evaluated in this paper. Caution is raised on not actively looking for neurologic AE, and for not considering causation when the incidence rate is too low to raise a calculable difference to natural occurence.
Keywords: OspA, Lyme disease vaccine, outer surface protein A, neurologic adverse events
DOI: 10.3233/JRS-2011-0527
Journal: International Journal of Risk & Safety in Medicine, vol. 23, no. 2, pp. 89-96, 2011
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