Affiliations: Triple J Group for Molecular Cell Physiology,
Department of Biochemistry, Stellenbosch University, Private Bag X1,
Matieland 7602, South Africa | Manchester Centre for Integrative Systems Biology,
Manchester Interdisciplinary Biocentre, The University of Manchester, 131
Princess Street, Manchester, M1 7DN, UK
Abstract: Systems Biology requires a tight integration of experimental data
and detailed computer models to obtain a quantitative understanding of the
system under study. To facilitate this integration a standardization of data
and model representation and storage is important. We illustrate here such an
integration using JWS Online, the modeling tool developed in our group. We
follow the approach of the Silicon Cell project for the construction and
validation of kinetic models and discuss some issues with respect to storage of
experimental data and models. The majority of the published kinetic models for
biological systems have been developed for metabolic networks and this will be
our focus in this manuscript. It is not our aim to present here an all
encompassing method for data and model integration, but rather to present our
work on this topic to start a discussion in which the different initiatives,
methods and tools can be compared.
