Abstract: A comparative genome analysis on exon-intron distribution profiles
is performed for human and mouse genomes to deduce similarities and differences
between them. Interestingly, both in human and mouse genomes, the total length
in introns and intergenic DNA on each chromosome is significantly correlated to
the chromosome size. The results presented provide a framework for
understanding the nature and patterns of exon-intron length distributions, the
constraints on them and their role in genome design and evolution.