An Analysis on Gene Architecture in Human and Mouse Genomes

Article type: Research Article

Authors: Sakharkar, Meena Kishore | Perumal, Bagavathi S. | Sakharkar, Kishore R. | Kangueane, Pandjassarame

Affiliations: Nanyang Centre for Supercomputing and Visualization, Nanyang Technological University, Singapore 639798 | BioInformatics Institute, 30 Biopolis Street, #07-01, Matrix, Singapore 138671

Note: [] Corresponding author. Tel.: +65 6790 5836; Fax: +65 6791 1859; E-mail: [email protected]

Abstract: A comparative genome analysis on exon-intron distribution profiles is performed for human and mouse genomes to deduce similarities and differences between them. Interestingly, both in human and mouse genomes, the total length in introns and intergenic DNA on each chromosome is significantly correlated to the chromosome size. The results presented provide a framework for understanding the nature and patterns of exon-intron length distributions, the constraints on them and their role in genome design and evolution.

Keywords: Exon, intron, length, shape, genome architecture, genome design, human, mouse, comparative genomics, distribution, profiles, correlation, genome size, architectural constraints, chromosome, gene density, content

Journal: In Silico Biology, vol. 5, no. 4, pp. 347-365, 2005