Abstract: The IGMS is a comprehensive information system that combines the
knowledge from genomic sequence, genetic map and genetic disorders databases.
This system is updated weekly and focuses on the analysis of EST data. The IGMS
identifies UniGene clusters that are differentially expressed in different
types of cancer with respect to different reference tissues. The results can be
combined with clinical data to asses the potential relevance of specific genes
for patient survival or metastatic spread. The second application maps EST with
a specific expression profile. Our third application generates a database of
alternative splice forms for nine organisms from EST and mRNA sequence data.
The results can be used to find splicing patterns specific for certain tissues
or tumour types. Availability: http://www.bioinf.mdc-berlin.de/igms/.
Keywords: alternative splicing, ESTs, database, gene expression profiles, colon cancer