Affiliations: Institute of Cytology and Genetics SB RAS,
Abstract: A new approach to recognizing promoter regions of eukaryotic genes
is proposed and illustrated by an example of Drosophila melanogaster. The
essence of its novelty is in realizing the genetic algorithm to search for
optimal partition of a promoter region into local nonoverlapping fragments and
selection of the most significant dinucleotide frequencies for the fragments
obtained. The method developed was applied to recognizing TATA-containing
(TATA+) and DPE-containing (DPE+) promoters of Drosophila melanogaster genes.
The program for promoter recognition is included into the GeneExpress system,
section RegScan (http://wwwmgs.bionet.nsc.ru/mgs/programs/proga/).