Affiliations: [a] Department of Genetics, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran | [b] Infertility and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran | [c] Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti of University of Medical Sciences, Tehran, Iran | [d] Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, No 23, Shahid Labbafi Nejad Educational Hospital, Tehran, Iran | [e] Department of Midwifery, Faculty of Midwifery, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran
Correspondence:
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Corresponding authors: Robabeh Taheripanah, Infertility and
Reproductive Health research center (IRHRC), Shahid Beheshti University of Medical Sciences, Tehran,
Iran. E-mail: [email protected].
Sayyed Mohammad Hossein Ghaderian, Shahid Beheshti University of Medical
Sciences, Tehran, Iran. E-mail: [email protected]
Abstract: BACKGROUND: One of the major problems in IVF is the poor response of the ovary to gonadotropins. ESRI and FSHR are two effective genes on controlled ovarian hyperstimulation (COH). OBJECTIVES: Evaluating the correlation of alleles and genotypes of polymorphism (-29G/A) located in the FSH receptor gene and polymorphism (XbaI G/A) located in Estrogen receptor genes with the ovary’s response would help to anticipate the results of ovulation in IVF cycles. METHODS: In the present study, two hundred (200) blood samples were taken from infertile women aged 20 to 39 who were under IVF therapy. After DNA extraction from the samples, real-time PCR was performed using a specific probe-primer. RESULTS: Statistical analysis revealed that the frequency of alleles and genotypes of polymorphisms (-29G/A) and (XbaI A/G) in women with normal to poor response did not have significant correlation.
