On the antigen-antibody interaction: A thermodynamic consideration

Article type: Research Article

Authors: Voets, Philip J.G.M.

Affiliations: Department of Internal Medicine, Radboud University Medical Centre, Geert Grooteplein Zuid 10, 6525 GA Nijmegen, The Netherlands | E-mail: [email protected]

Abstract: Despite its relevance to many biomedical fields, relatively little effort has been put into a comprehensible quantitative description of the effect of reaction temperature on the interaction between antigens and their antibodies. In this article, a novel, straightforward mathematical model is proposed, which aims to describe the effect of temperature on antigen-antibody kinetics. The model proposed in this article could hopefully provide clinicians, immunologists, and biochemists with an improved insight into the kinetic effect of fluctuations in reaction temperature on antigen-antibody-dependent processes and therefore into the kinetics of the humoral adaptive immune response.

Keywords: Antigen, antibody, kinetics, temperature, mathematical model

DOI: 10.3233/HAB-170319

Journal: Human Antibodies, vol. 26, no. 1, pp. 39-41, 2018