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The level of risk, effects response to potential health emergencies, prevention and control method of COVID-19: A systematic review



The novel Coronavirus Disease 2019 is the major public health burden in the world. The disease and death of the global community from corona virus disaes 19 rapidly increasing from time to time worldwide. However, there was a lack of well-organized information about the level of risk, effects, prevention and control methods of the disease. Therefore the aim of this study was to identify and review a published level of risk, effects response to potential health emergencies, prevention, and control methods of Coronavirus Disease 2019 at the global level.


A systematic review was performed after literatures were identified by searching the following online databases: medRxiv, Google scholar, PubMed, MEDLINE, EMBASE, and the Cochrane Library with supplementary hand searching of conferences. The online databases contain archives of most English biomedical journals. Scientific papers published online by the Center for Disease Control and the World Health Organization were also included for this analysis. The scientific publications from 1 December, 2019 to 13 April 2020. were included. The ‘COVID-19’, ‘2019 novel coronavirus’, ‘2019-nCoV’, ‘novel coronavirus’, and ‘Pneumonia’ key search terms were used in this review.


Twenty published articles with reputable journals met the inclusion criteria, representing 20 articles analyses. From these, 11 (55%) in China and 3 (15%) in United State of America. All the 20 were statistical analyses of individual patient data, while 33 used decision-analytic modeling. The overall structures were most commonly described as being Markov (n= 27) but, the methods were heterogeneous. The World Health Organization was reported that most frequently world communities including health care providers were ‘alive’ or ‘dead’, with COVID-19 related outcomes such as hospitalization and other enclosed

action of class distribution most commonly considered as a partition of the ‘alive’ state. Different approaches to modeling the effects of COVID-91 prevention and control interventions on mortality were used; treatment effects were applied to cardiovascular mortality and all-cause mortality in nine and 20 studies (among the 33 decision-analytic models), respectively. Across included studies, the time horizon ranged from within-trial to lifetime. Outcomes were frequently sensitive to baseline risks of mortality and hospitalization, the relative efficacy of interventions, and unit costs of interventions.

The identified literature findings showed that the morbidity and mortality rate including urgent hospitalization is increasing from day today. Therefore, the world continents countries should implement COVID-19 prevention and control programes. Moreover; urgent global collaboration is needed in order to design effective prevention and control strategies as soon as possible.

Keywords: Coronavirus disease 2019, level of risk, potential health emergencies, prevention and control


Coronavirus had been observed as Epidemic diseases since 2003 and it has also caused many community health problems that resulted in Global serious issues. Moreover, these cases consecutively occurred as a severe acute respiratory syndrome (SARS), middle east respiratory syndrome (MERS), and Coronavirus disease 2019 (COVID-19) [1]. There is a new community health problem threatening the glob with the emergence and spread of COVID-19 or the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The virus started in bats and was transmitted to humans through yet hidden intermediary animals in Wuhan, Hubei province, China in December 2019 [2].

The COVID-19 is basically transmitted by respiratory beads and near contact. Pulmonary function testing procedures have been associated with an increased risk of COVID-19 transmission from clients and health professionals [3].

The changing transmission situations, specifically, nosocomial transmission and spread through mildly symptomatic cases is a range of concern. There is a range of signs and symptoms from mild to serious killer disease with major complications such as severe pneumonia, ARDS, acute cardiac injury and septic shock. Bilateral ground-glass opacity and consolidation on imaging with possible clinical features should raise a suspicion about COVID-19. Destitute prognostic regions such as Multilobular infiltration on chest imaging, Lymphopenia, Bacterial co-infection, Smoking history, Chronic medical conditions like Hypertension, and age > 60 years (MuLBSTA score) [4]. The COVID-19 outbreak that was started in Wuhan, Hubei province, China in 31 December, 2019 and now it is pandemic with > 100,000 cases and 3,000 deaths reported in 93 countries as of 7 March 2020. They have a COVID-19 infection report in a 64-year-old man who developed rapidly worsening respiratory failure and acute respiratory distress syndrome (ARDS) that required intubation. As the clinical spectrum of COVID-19 ranges widely from mild illness to ARDS with a high risk of mortality, there is a need for more research to identify early markers of disease severity [5].

Then the Chinese authorities have restricted some travel to try and stop the illness since 23 January 2019 and China’s financial markets will remain closed until Monday 3 February 2019 after authorities extended the Lunar New Year holiday break by three days. It rapidly spreads all over the world then World Health Organisation had declared this disease as pandemic 11 March 2020.

A cluster of patients with pneumonia of unknown cause was linked to a seafood wholesale market in Wuhan, China. A previously unknown betacoronavirus was discovered through the use of unbiased sequencing in samples from patients with pneumonia. Human airway epithelial cells were used to isolate a novel coronavirus, named COVID-19 which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily. Different from both MERS-CoV and COVID-19; SARS-CoV-2 is the seventh member of the family of coronaviruses that infect humans. Enhanced surveillance and further investigation are ongoing (Funded by the National Key Research and Development Program of China and the National Major Project for Control and Prevention of Infectious Disease in China) [6].

Data are lacking on the impact of Middle East Respiratory Syndrome (MERS) on health-related quality of life (HRQoL) among survivors. Functional scores were similar for MERS and non-MERS SARI survivors. However, MERS survivors of critical illness reported lower quality of life than survivors of less severe illness. Efforts are needed to address the long-term medical and psychological needs of MERS survivors [7].

The first Chinese data published seem to show that the symptoms in pregnant women are the same as those of the general population. There are no cases of intrauterine maternal-fetal transmission, but cases of newborns infected early suggest that there could be vertical prepartum or neonatal transmission. Induced prematurity and cases of respiratory distress in newborns of infected mothers have been described. Pregnancy is known as a period at higher risk for the consequences of respiratory infections, as for influenza, so it seems important to screen for Covid-19 in the presence of symptoms and to monitor closely pregnant women.In this context of the SARS-Covid-2 epidemic, the societies of gynecology-obstetrics, infectious diseases, and neonatology have proposed a French protocol for the management of possible and proven cases of SARS-Covid-2 in pregnant women [8].

Predicting the number of new suspected or confirmed cases of COVID-19 is crucial in the prevention and control of the COVID-19 outbreak. Social media search indexes (SMSI) for dry cough, fever, chest distress, coronavirus, and pneumonia were collected from 31 December 2019 to 9 February 2020. The new suspected cases of COVID-19 data were collected from 20 January 2020 to 9 February 2020 [9].

The COVID-19 pandemic is first and foremost a humanitarian crisis. Efforts to contain the virus and support those directly impacted are of utmost importance. The COVID-19 pandemic is an unprecedented global shock that magnifies the impact of inequality, hitting the poor the hardest. In developed countries, frontline workers in the service economy are among the most exposed to the virus and the least able to absorb its financial impact. And the hardest hit will be the poor in developing countries, where already-struggling workers will not have the benefit of social safety nets and stimulus packages. The G7 and G20 must immediately help these countries to finance the flattening of the pandemic curve. Longer-term, we must redouble efforts to foster sustainable economic systems, including fair trade and investment [10].

Awareness and attentiveness have implications for the acceptance and adoption of disease prevention and control measures. Social media posts provide a record of the public’s attention to an outbreak [11]. The effect of corona discharge-generated air ions on the filtration of aerosolized bacteriophage MS2 was studied. A carbon-fiber ionizer was installed upstream of a medium-efficiency air filter to generate air ions, which were used to charge the virus aerosols and increase their filtration efficiency. After the virus aerosols were captured by the filter for a certain time interval, they were exposed to a new incoming air ion flow [12].

The emergency that the world faces today demands that we develop urgent and effective measures to protect people at high risk of transmission. WHO has accelerated research in diagnostics, vaccines, and therapeutics for this novel Coronavirus [13]. The aim of this review study was to identify and review a published level of risk, effects response to potential health Emergencies, prevention, and control method of the COVID-2019 outbreak. This review will serve to provide well-organized information for the global community in this regard.


The method was used asses level of risk, effects response to potential health Emergencies, prevention, and control method of Coronavirus disease 19 from published and unpublished works worldwide. The following procedures are used in this review; choosing appropriate research objective and search strategies; collecting important articles; choosing research articles; extracting and recording of data; finally, summarization, discussion, analyzing, and reporting the results were conducted.

2.1Literature search strategies

A systematic review was performed after literatures were identified by searching the following online databases: medRxiv, Google scholar, PubMed, MEDLINE, EMBASE, and the Cochrane Library with supplementary hand searching for conferences. The online databases contain archives of most English biomedical journals. Additionally, Scientific papers published online by the Center for Disease Control and the World Health Organization and reputable organizational recognized websites from health sectors and other related sectors and /organizations were included.

This strategy was utilized to decide the precision of the results by comparing them within the related articles from different reputable and key important sources. The review is based on peer-reviewed journal articles on “level of risk, to potential health emergencies, “effects response to potential health emergencies, and prevention and control methods” that were published from 31 December 2020 to 20 April 2020. This time span was chosen because the current diseases outbreak and its up-to-date information is important to justify and address the objective of the review articles. The ‘COVID-19’, ‘2019 novel coronavirus’, ‘2019-nCoV’, ‘novel coronavirus, and ‘Pneumonia’ key search terms were used in this review.

Firstly, assessed all searched articles using inclusive criteria, then after assessing all titles and inside of the articles, the value of the articles to address the aim of this study was assumed, and examined. The terms used for searching related articles were “Potential health” “Emergencies”, “prevention”, “control”, “Coronavirus-2019” Pandemic Diseases”, “Viral infections”. Also “Risk and effect response” and “Emergency preparedness” were used together to search the articles from different key relevant databases and official governmental and nongovernmental websites including reports.

The investigators have used the Effective Public Health Practice Project Quality Assessment Tool (EPHPP) (EPHPP, 2020) to assess the quality of quantitative research in this review. This instrument had ordinal scoring for the following components: selection bias, study design, confounders, blinding, data collection methods, withdrawals and dropouts. It helps to assess review study quality and develop recommendations for study results. Each component was rated strong, moderate, or weak, and these ratings were also combined into a global quality rating (strong, moderate, or weak). Two reviewers assessed the quality, and discrepancies were resolved by discussion.

2.2Inclusion and exclusion criteria

The research team read the titles and decided to include articles in the review regarding the following criteria: the study included relevant key instruments to collect raw data including media and other information on the level of risk and effects response to potential health emergencies, prevention, and control method of COVID-2019 outbreak inclusion of only Novel COVID-19; SARS-CoV-2 outbreak which is currently critically and life-threatening cause of the pandemic disease globally. All articles that were published between 1 December 2020 and 13 April 2020, and those published in English were eligible for the analysis.

From those searched studies that didn’t meet these criteria were excluded. This review is focused on the level and/or extent of emergency response for slow COVID-19 transmission, the effects of response to potential health emergencies towards COVID-19 and how to prevent, and control COVID-19. Furthermore, the review identified the main characteristics of COVID-19, effects of emergency preparedness and prevention, and control by hand washing using soap and sanitizer, isolation, quarantine, far from infected and suspected persons, and emergency contact with health care provider if there are any symptoms of COVID-19. All abstracts were excluded from this review article. For instance, articles about the impact of a severe acute respiratory syndrome (SARS) care on the general health status of health care workers, Middle East Respiratory Syndrome (MERS), and other than directly related to the COVID-19 outbreak were excluded from this review.

2.3Data collection and analysis

After the literature search, articles were screened independently by two reviewers for eligibility. A third reviewer was consulted to resolve disagreements. We included studies published in English. Two reviewers had independently reviewed the titles, authors, published year, and abstracts against eligibility criteria.

2.4Prisma flow diagram

The research team has searched a total of 132 articles. The titles, summary or abstract, and the whole body of each article were then checked for their relevance and suitability to be included in the analyses. Finally, a total of 20 articles were found to be eligible (Fig. 1).

Figure 1.

Total number of sample size of the reviewed articles.

Total number of sample size of the reviewed articles.


A total of 20 reviewed studies, 11 (55%) were conducted potential health emergencies, prevention, and control methods of COVID-19 outbreak COVID-19 in China in 2020. This indicated that almost all (100%) of the studies were employed from 31 December 2020 and 13 April 2020. Among those, 11 (55%) researches were conducted in China [16, 18, 20, 21, 22, 23, 28, 29, 30, 32, 33]. About 3 (15%) researches were studied in the United State of America [17, 26, 27]. The remaining studies (30%) were conducted in Brazil (5%), Switzerland (5%), California (5%), Korea (5%), Hong Kong (5%), and India (5%) respectively [14, 16, 19, 24, 25, 31].

The ocurance of pandemic COVID-19; SARS-CoV-2 outbreak situation starts from Wuhan, Habie city, China and transmitted to world countries with diseases manifest itself for all communities without age, gender, ethnicity, religious, position, authority, education, occupation, country, regions, richness, poorness, and color differences among the world population. Eleven of twenty reviewed studies were conducted, suspected cases and deaths reported as well.

Among 20 studies, 6 (30%) studies analyzed the vulnerability of patients and health professionals with COVID-19 and investigate the clinical outcome of patients with moderate type of COVID-19 after discharged by retesting viral nucleic acid, the epidemiological charactesrtics and dynamics of confirmed COVID-19 cases related with the transmission in Incubation periods of first cases, transmision and its association with population emigration [25, 29, 32, 33, 14, 28] and, followed by 4 (20%) studies analyzed the development of institutional algorism to protect operating room team members during the COVID-19 pandemic and rationally conserve personal protective equipment, the incidence of COVID-19 infection among people under home quarantine and its effectiveness and great attention of a pre-established nationally representative Cohort of Weibo user was searched for COVID-19 related key words in their posts [19, 20, 23, 25].

About 3 (15%) studies analyzed the effectiveness of the school closure effects on the COVID-19; SARS-COV-2 outbreak, the public health investigation of a mildly ill, non hospitalized COVID-19 case who traveled to China and how the health care provider can support all communities to relieve existing health security capacities against public health risks and events [15, 24, 26], 2 (10%) studies analyzed the available evidence about COVID-19 and the International community with a deeper understanding of this new infectious diseases [16, 31], 2 two studies (10%) analyzed the investigating the content of You-tube videos related to COVID-19 gaps in the current knowledge and the incidence of 2019-nCoV infection among people under home quarantine [23, 27].

The remaining 3 (15%) studies analyzed the response from various health sectors as such district to generalized Hospitals, private and public hospitals, health centers, clinics, and temporary emergency response centers including all other sectors waiting area, the regional blood center, and the hospital-based transfusion services to the events that took place in the community phases of COVID-19 pandemic [17].

The role of the newly established and technological product of internet hospitals during the prevention and control of Novel 2019 infectious pandemic diseases outbreak (COVID-19; SARS-CoV-2) [21], and importance and the main role of community pharmacists’ including the content of pharmaceutical care to slow transmission of COVID-19 [22]. Moreover, the review study was focused on the importance of emergency response such as quarantine, isolation, the distance between persons and other prevention and control methods for COVID-19 in various countries as well as key information about the meaning of COVID-19, way of transmission, causes and epidemiologic characteristics, management and ways to prevent and control it.

The majority of the reviewed articles (65%) selected a sample size between 1 and 400 [14, 15, 16, 19, 22, 25, 26, 27, 28, 29, 31, 33], and followed by 5 (25%) studies were selected a sample size 1200 [21, 23, 25, 30, 32]. Meanwhile, 1 (5%) study selected samples between 801 and 1200 peoples [17], and the other 1 (5%) study selected samples between 401 and 800 [18] (Fig. 2).

Figure 2.

Total number of sample size of the reviewed articles.

Total number of sample size of the reviewed articles.

In this review, 6 (30%) findings utilized a brief history and laboratory examination official cases to identified confirmed diagnosis on COVID-19; SARS-CoV-2 outbreaks and to answer the research questions [17, 26, 29, 32, 31, 33].

About 3 (15%) studies used a situational analysis in order to address the reviewed questions [15, 14, 25], and 3 (15%) studies were used an interventional platform PPE taskforce, develop model and simulation study to address review questions [19, 20, 24]. Only 2 (10%) research articles were used clinical examination and epidemiological study to answer review questions [16, 28] and 2 (10%) studies were used descriptive cross-sectional study [18, 27]. The remaining 4 (20%) studies were used online survey (5%) [18], a summary of experiences 3 (5%) [22], online epidemic related consultants (5%) [21] and longitudinal Cohort 3 (5%) [25] to address review questions.

This review required to generalize results from the mentioned articles by identifying a wide variety of the level of risk, effects response to potential health Emergencies, prevention, and control methods COVID-19 that might be prevented and controlled the transmission of the infectious pandemic outbreak diseases in world notion. These results show the different instruments used to measure the level of risk, effects response, and overall characteristics of COVID-19. Operation room, guideline, well mixed SEIR model, laboratory results, Endoscopes, interventional suites and other devices like Multicenter internet Hospitals’, which accounted for 55% of articles on response to potential health Emergencies, prevention and control method of COVID-19 was the highly ranked used strategy [19, 21, 20, 23, 24, 26, 27, 28, 30, 31, 33].

It was followed by 5 (25%) studies list of the Hospitalized patient with COVID-19 and the daily number of new confirmed cases [14, 16, 25, 29, 32]. The remaining 4 (20%) studies State party annual Reporting (SPAR) tools (5%) [15], Blood supply and transfusion Units (5%) [17], Patient pharmaceutical care and drugs and other supplies (5%) [22], and the depression, anxiety, and stress scale and the impact of event scale revise (5%) [18]. About 4 (20%) studies were analyzed using situational analysis and response-based analysis to identify the result of the reviewed study [14, 17, 28, 22], and followed by 3 (15%) [21, 23, 29], and 3 studies (15%) follow up and busing channels [27, 33, 25] whereas 2 (10%) studies were using clinical features and treatment of COVID-19 [26, 16], 2 (10%) studies indicated the epidemic curve of the period over the period growth rate of the new confirmed cases [30, 31]. The remaining 6 (30%) studies were used various analyzing method to identify the problem and its alternative solution, transmission parameters (5%) [24], Baidu Qlaux and Correlation ArcGIS and Win Bugs software (5%) [32], Six Geographic WHO regions (5%) [15], psychological impact and mental status (5%) [23], Considering infected individuals as contagious during the latency period (5%) [20] and develop guideline, health policies and other legislation (5%) [19].

In this review, 6 (30%) studies were used systematic way of assessing the community and health care providers awareness and belief on COVID-19 transmission, prevention, epidemiologic charactesrtics, management and how to implement WHO prevention and control protocol and its purpose to slow COVID-19 transmission [16, 17, 22, 25, 27] followed by 4 (20%) studies were assessed and identified the vulnerability of a community contact with suspected and confirmed COVID-19 cases and evaluate its epidemic outbreaks [14, 21, 26, 31] and 4 (20%) studies were assessed the main target related prevention and control, detection, enabling, emergency responses, operational readiness, and public health emergency including efficient and effective hand washing practices [29, 15, 24, 28].

In addition, 3 (15%) studies were detected how we can develop the common algorism for the majority part of COVID-19 transmission methods by using various personal protection equipment and well mixed SEIR Model in order to identify the new case of COVD-19 and how we can control the speed of transmission [20, 19, 25], and 3 (15%) studies have calculated the incidence and basic characteristics of the pandemic COVID-19 outbreak [23, 32, 33] (Table 1).

Table 1

Level of risk, effects response to potential health emergencies, prevention and control methods of coronavirus disease 2019

Author and year publicationCountryPurpose of the studySample sizeMethodsTargetMaterials/ instruments
et al. [14]BrazilTo assess the susceptibility of patients and health professionals with COVID-19NASituational Analysis-Identify vulnerable oneHospitalized Patient with COVID-19
et al. [15]SwitzerlandTo relieve existing health security capacities against COVID-19182 CountriesSituational Analysis-Prevention -Detection -Responding -Enabling Operational readiness18 indicators from the IHR state party Annual Reporting (SPAR) tools
et al. [16]ChinaTo provide the awareness of COVID-19 among International community135 countriesClinical assessmentCommunity awarenessHospitalized Patient with COVID-19
et al. [17]Washington DCTo describes the response of public health emergency like blood transfusion from the Hospitals and the regional blood centers704 confirmed casesBrief reportEncouraging blood donation and Community and health care provider awarenessBlood supply and transfusion Units
et al. [18]ChinaTo survey the level of knowledge on mental health condition and stress during the initial of the COVID-19 outbreak1210 respondents from 194 citiesOnline survey-Precautionary measures against COVID-19-The impact of Event Scale Revise (IES-R) -Depression, Anxiety and Stress Scale (DASS-21)
et al. [19]CaliforniaTo develop an Institutional algorism to protect operating room team members during the COVID-19 pandemicNAAn interventional platform PPE taskforce-Developing common algorithm for PPE user-Operating room -Interventional suites -Endoscopes -Guidelines
et al. [20]ChinaTo explore the effectiveness of the quarantineNAA well mixed sustainable exposed infectious recovered compartmental ModelThe dynamic of the COVID-19 epidemic -Epidemiological charactesrtics of IndividualWell-Mixed SEIR Model
et al. [21]ChinaTo explore the role of internet hospitals during the prevention and control of COVID-194913 consultantsOnline epidemic related consultantsCompared with reported COVID-19 patientsMulticenter internet hospitals
et al. [22]ChinaTo address community pharmacists’ role and the content of pharmaceutical care during the novel COVID pandemicCommunity Pharmacy management teamSummary the experienceSafe drugs use of the community, patient and populationPatient pharmaceutical care
Wang [23]ChinaTo estimate the incidence of 2019-nCoV infection among people under home quarantine2004 peopleDescriptive cross sectional study-To calculate the incidence-laboratory results
et al. [24]KoreaTo quality the school closure effects on the COVID-19 epidemic60 casesMathematical Model and simulation studyAssess the school closure and its valueMathematical Model

Table 1, continued

Author and year of publicationCountryPurpose of the studySample sizeMethodsTargetMaterials/ instruments
et al. [25]HongkongTo measure the attention of Chinese netizens to COVID-191101 Weibo accountsLongitudinal CohortAttention quickly incr easedWeibo Accounts
et al. [26]USATo describe the public health investigation of a mildly ill, non hospitalized COVID-19 case who travelled to China35 specimensLaboratory diagnostic evaluation/ReportAssess the investigation resultsSpecimens
et al. [27]United StateTo address the investigating the content of You tube videos related to COVID-19100 You tube videosCross sectional studyAssess the gap in the current awarenessYou Tube Videos
et al. [28]ChinaTo analyze the epidemiological charactesrtics of a cluster COVID-195 cases in January, 2020The National health Commission, a field epidemiological survey-Find out the source and transmission chain-Nasopharyngeal swabs -Sputum sample
et al. [29]ChinaTo describe the epidemiologic charactesrtics of COVID-19135 confirmed cases, 3 deaths, and 87 recoveriesDaily notification ReportTo provide scientific of prevention and control measuresData from COVID-19 cases
et al. [30]ChinaTo evaluate the epidemiologic dynamics of COVID-1950,031 Confirmed cases (COVID-19)Analysis and reportsTo master the epidemic trend of COVID-19Daily number of new confirmed COVID-19
Khot and Nadkar [31]IndiaTo review the available evidence of Novel 2019 Corona Virus outbreakNAInvestigation/ Diagnostic confirmationEvaluate of a new corona virus epidemicPCR
et al. [32]ChinaTo determine case distribution and its correlation with population emigration9805 casesOfficial case report-Early warning -Prevention of future outbreaksData on population migration
et al. [33]ChinaTo investigate the clinical outcome of patients with moderate type of Corona Virus2019 (COVID-19) after discharged7 patientsTest SARS-CoV-2 nuecleic acid by RT-PCR mtodsAssess the over all clinical out comes related with Death-Documentation -Sputum or nasal swab -Feces

In this review, 4 (20%) studies an intervention was focused on elders age groups and new migrants and journey related case groups and/or suspected vulnerable groups [14, 25, 31, 32] followed by 4 (20%) studies suggested that most of the time, infected patients with the COVID-19 infection and having severe symptoms had lower lymphatic counts and higher plasma level of Pt, APTT, D-dimer, LDH, PCT, ALB, CRP, and AST and other laboratory test results [33, 26, 16, 28].

The group transmission was a possible way to transmitted COVID-19 from one area to another since on March 23, 2020. The evidence showed that the number of expected cases are lower depends on the time of quarantine and it may change the incidence of COVID-19 in children from 28.4 to 33.6 for 7 and 14 days. [24, 25], and pharmaceutical effects were one of vital management system for COVID-19 but, still, there is lack of effective medicine to manage the COVID-19 and vaccine to protect transmissions [22, 23].

About 2 (10%) studies were identified as the capacity to prevent, investigate, and control COVID-19 varies from country to country which indicates a wide variety of implementation of control method to slow COVID transmission [20, 15]. The finding showed that the world communities are vulnerable to COVID-19 and there was rated the psychological and mental impact from moderate to severe stages [23, 25]. The remaining 4 (20%) studies were showing that a decision tree algorism is using to describe the health institution guideline for acting any precautions for all departments and most of the time, operation room team members [19], the emergency based treatment like blood transfusion are a significantly observed treatment for COVID-19 at the first week of diseases outbreak occurred in China [17].

Most of the reviewed studies results showed that the case fatality and the incidence of COVID-19 was 22% and 8-65/1000000, respectively [29] and fewer than one-third of the videos covered any of the seven key prevention behaviors listed on the United States centers for diseases control and prevention websites [27].

The review showed that COVID-19; SARS-CoV-2 is one of the most killer diseases of global communities and it needs urgent public health emergency to slow transmissions. Therefore, this review was identified as various problems related to COVIOD-19 and its conclusion. The 6 (30%) studies were suggested that there is a shortage of community and health care providers awareness and lack of training for health professionals related to the psychological and environmental impact of COVID-19 [14, 20, 25, 26, 27, 28], and followed by the epidemic prevention and control measures taken by the state and government at all level of health shown very significant effects [29, 32, 31, 30]. In other way 3 (15%) studies were agreed that the implementation of efficient and effective potential health emergency response are critically important to slow COVID-19 transmission from person to person via world notions [15, 22, 18].

The remain 7 (35%) studies were suggested that the possibility of massive transmission in the children’s age grouping is lower [24], there is a relatively high incidence of positive viral nucleic acid in patients met the discharged from hospital criteria [33], Some of the viral pneumonia cases has treated with scientifically approved traditional Chinese medicine and other drugs like Kaletera as combination form [16].

Moreover, in the glob, most of the district to specialized hospital activities are switched from day to day activities and operations to (COVID-19) and overall people, routine activities are highly disrupted at both developing and developed countries [21, 17]. Also agreed that internet hospitals can be server various kinds of endemic, epidemic, pandemic and sporadic diseases outbreak counselees, and offer special to the community at the time being COVID-19 outbreak and lower psychological impact of the COVID-19 [18] including ensuring optimal health care workers safety are vital to slow COVID-19 transmission [19].

In this review, 7 (35%) studies recommended that mass quarantine and isolation action must give great attention on government and community side [14, 18, 20, 27, 28, 29, 31] because it helps to slow COVID-19 transmission and decrease morbidity and mortality rate at both low, middle and high-income countries. And followed by 5 (25%) studies suggested that currently, COVID-19 is one of the public emergency and life-threatening problem; therefore facilitating the epidemiology screening and proactively communicate early warning in transparent manners and behaviors [16, 21, 25, 30, 32].

Figure 3.

Total number of active cases of COVID-19 outbreak from 31 December, 2019 up to 20 April, 2020.

Total number of active cases of COVID-19 outbreak from 31 December, 2019 up to 20 April, 2020.

Figure 4.

Total number of closed cases of COVID-19 from December, 2019 up to 20 April, 2020.

Total number of closed cases of COVID-19 from December, 2019 up to 20 April, 2020.

About 2 (10%) studies recommended that formulating psychological management and follow up including viral testing should be implemented to identify the severity, magnitude, negative and positive result and/or confirmed cases and total death of the COVID-19 infected persons [33, 18]. The remaining 6 (30%) studies indicated that capacity building and collaboration between countries are critically important (5%) [15], further studies related with newly proved combined medication like Kaletera and Chinese traditional medicine in the treatment of COVID-19 is advisable [16].

Emergency care blood transfusion and utilization of existing supportive managements encourage the health care providers should take precautions before, during and after operating room activities [19], preparing a community-based pharmacy [22] and the state and government should develop various health and health-related model and simulation are the most commonly advisable recommendation to slow COVID-19 transmission across the world [24] (Table 2).

Table 2

The study using to identify the level of risk, effects response to potential health emergencies, prevention and control methods of coronavirus disease 2019

Author and year of publicationAnalysisResultsConclusionRecommendation
et al. [14]SituationalThe majority of the intervene ion were focused on elders and new migrantsLack of training for providing mental health careFear seems more certainly a consequence of mass quarantine
et al. [15]Six Geographic WHO regionsCountries vary widely interms of their capacity to prevent, detect and respond to outbreakAn effective response to potential health emergencies could be enabledCapacity building and collaboration between countries are needed to strengthen global readiness for outbreak control
et al. [16]Clinical features and treatment of COVID-19The severe cases had lower lymphocytes counts and high plasma levelKaletra and Traditional Chinese medicine played an important role in the treatment of the Viral pneumoniaFurther studies are required to explore the role of Kaletra and Traditional Chinese medicine in the treatment of COVID-19
et al. [17]Response based analysisBlood donations was dropped significantly at the first week of COVID-19 occurred in the countryAs communities activities are disrupted and hospital activities switch from Routine, operations to pandemic focusedUrgent care oriented, the blood supply and utilization requires of transformations
et al. [18]Psychological impact and mental health Status assessment -Descriptive statisticsMost of respondents rated the psychological impact of the outbreak as moderate to severeSpecific up to date and accurate health infection and particular precaution measure were associated with a lower psychological impact of the put break (P< 0.005)Formulate psychological interventions to improve the mental health of Vulnerable groups during the COVID-19 epidemic
et al. [19]Developing Guidelines by conjunction with our infectious diseases expertsA decision tree algorism describing our Institutional guideline for precautions for operating room team members was createdTo ensure optimal health care workers safetyTo encourage the health care professional should take precautions before, during and after operating room activities
et al. [20]Considering infected individuals as contagious during the latency periodThe possible impact of questionnaire and isolation intervention on diseases infectiousBy reducing the contact rate of latent individual, quarantine and isolation could be effectively reduce the potential peak number of COVID-19To initiate the communities upon quarantine and Isolation action to minimize the risks.
et al. [21]-Evaluate the social panic of the epidemic -logistic regression modelReduce the chance of nasocommial cross infectionInternet hospitals can serve different types of Epidemic counselees, offer especial to the public during COVID-19To facilitate epidemiology screening
et al. [22]Analyze the methods and strategiesPharmaceutical care services in communities during the COVID-19 shall posses different properties due to diseases charactesrtics and related change in the patients needCommunity pharmacies shall work as a strong supporter of patients medication and protective equipment supplyCommunity pharmacy shall be prepared to provide skill and effective PC services for community, patient,population to ensure medication safety and promote the overall COVID-19 pandemic control
Wang [23]Descriptive analysis< 1% participants reported contact history with confirmed or suspected cases during their trip between January, 24–27, 2020The incidence of COVID-19 in the sample was 1.5%Home quarantine is effective prevention and control COVID-19
Kim et al. [24]Transmission parameters-The number of expected cases for children is 28.4 for 7 days and 33.6 for 14 daysThe possibility of massive transmission in the children’s age grouping is lowerAny government should try to use the simulation and Mathematical Model to approve reduce the COVID-19 cases

Table 2, continued

Author and year of publicationAnalysisResultsConclusionRecommendation
Zhu et al. [25]Follow upAttention to COVID-19 was limited prior to China openly knowldging human to human transmission on January,2020Limited early warnings represents missed opportunities to engage citizens earlier in the outbreakGovernments should more proactively communicate early warnings in a transparent manner
Scott et al. [26]High-risk contact NP/OP Speciement for SARS-CoV-2 testing and following 14 daysAll tested (35 Speciemen) result were negativeSARS-CoV-2 infection can cause mild illness and result in positive tests for up to 18 days after diagnosis, with out evidence of transmission to close contactsPublic health strategies to mange individuals with asymptomatic infection or mild illness
Basch et al. [27]The videos viewed over 125 million timesFewer than one third of the videos covered any of the seven key prevention behaviors listed on the US centers for diseases control and prevention websiteThe results presents an important missed opportunity for diseases preventionEncourge effective preventive behaviours
Xiao et al. [28]Multi prevention and control measures analyzing transmission chainIt is the key point for epidemiological investigationThe epidemiological investigation indicates that the transimission might occur in the Incubation period of COVID-19 casesClose attention should be paid to it further COVID-19 prevention and control
Cao et al. [29]Descriptive analysisThe incidence of COVID-19 was 8.65/1,000,000 with a 2.22% case fatality ratePeople are generally suspectible to Coronavirus-19 which has shown a familiar clusterUsing synthefic measure for slow COVID-19 transmission
Zhu et al. [30]The epidemic Curve of the period over period growth rate of the new confirmed casesThere was declining the peak of the number of new confirmed cases in the countryThe epidemic prevention and control measures taken by the state and government at all levels have shown very significant effectEfficiency curbing the spread of the COVID-19 epidemic in China
Khot and Nadkar [31]Every decades has witnessed the evalauation of a new Coronavirus epidemics-Management is primarly supportive, with never antivirals (Lopinavir, Ritonavir and Remedesivi -Vigilant screening of suspected cases and their contacts is importantThe standard infection control and prevention techniques should be followed -Controlling this highly tranmsmissiable diseases requires international co-ordinationIsolation of symptoms cases and home quaranitine is asymptomatic contacts is recommended
Chen et al. [32]Baidu QIanxi and CorrelationThe number of cases in some cities in China was relatively lowSome cities with a low number of cases should be a rapid increases in case loadUnderstanding the risk trends in different region is crucial to ensure preparedness at birth the individual
Li et al. [33]Three weeks quarantined periodThere had no any sign and symptoms during the quarantine period in all 7 patients.There is a relatively high incidence of positive viral nucleic acid in patients met the discharge criteria-Follow up viral testing

3.1Confirmed cases, recovered and deaths due to coronavirus disease 2019

The reviews indicated the highest confirmed COVID-19 cases, 764,177 patients were registered from the United State of America starting from the onset of the disease up to 13 April 2020, and followed by Spain accounted 198,674 confirmed cases. However, the lowest COVID-19 confirmed cases, only one case was reported in Yemen, and still, nothing COVID-19 cases and deaths occurred in Bosnia and Herzegovina including Antarctica Continent. Regarding the death, the most deaths, 40,591 were registered in the United States and followed by 23,660 deaths in Italy, 21,238 in Spain, 19,718 in France, 16,060 in the United Kingdom, 5,683 in Belgium, 5,118 in Iran, 4,632 in China, 4586 in Germany, 3,684 in Netherland, 2,462 in Brazil, 2017 in Turkey, 1,587 in Canada, 1,540 in Sweden, 1,393 in Switzerland and the lowest rate of deaths it means the countries which had registered only one death per their confirmed COVID-19 cases from December 2019 up to 13 April 2020 were reached 15 (Burundi, Burundi, Gabon, Liechtenstein, Cape Verde, cayman islands, Libya, Benin, Botswana, Curacao, British version Islands, Suriname, the Gambia, and Mauritania) [34].

However, a total of 39 countries: Rwanda, Gibraltar, Cambodia, Madagascar, Reunion, Vietnam, Faroeisland, FrenchIslands, French Guinea, French Polynesia, Uganda, Maldives, Macao, Eriteria, Mozambique, Sierra Leone, Chad, Mongolia, Nepal, Timer-Leste, Laos, New Caledonia, Fiji, Dominica, Nambia, Saint Lucia, Saint Barthelemy, Falkland Island (Islas Malvinas), Green lands, Monsterrat, Seychelles, Vatican city, Papua New Guinea, Bloutan, South Sudan, Anguilla, and Yemen have had not any death (Zero Death Number) from their registered total number of confirmed cases as active and closed cases of COVID-19. The result also showed that there was no death report within 11 confirmed cases it means that either zero, one, or more deaths registered in the Aland Islands [33, 34] (Table 3).

Table 3

Total confirmed, case per 1 million people, recovered and deaths due to coronavirus disease 2019

LocationConfirmedCases per 1 million peopleRecoveredDeaths
United States764,1772,318.8170,17240,591
United Kingdom120,0671,807.2716,060
South Korea10,674206.148,114236
Saudi Arabia9,362273.61,39897
United Arab Emirates6,781685.611,28641
Dominican Republic4,680451.81363226
South Africa3,15853.7390354

Table 3, continued

LocationConfirmedCases per 1 million peopleRecoveredDeaths
North Macedonia1,207581.0917851
New Zealand1,105222.1197412
Hong Kong1,026136.796024
Côte d’Ivoire84732.82609
Costa Rica660130.491125
Burkina Faso57627.633836
San Marino46113,730.866039
Democratic Republic of the Congo3273.652625
Isle of Man2983,576.831936
Sri Lanka27112.43967

Table 3, continued

LocationConfirmedCases per 1 million peopleRecoveredDeaths
El Salvador20130.99447
Faroe Islands1853,549.231760
Republic of the Congo14325.91116
Myanmar (Burma)1112.0477
Northern Cyprus108331.29523
French Guiana97340.14690
Equatorial Guinea7958.1640
Sint Maarten671,649.68129
Cape Verde61110.8111
Cayman Islands61926.8771
The Bahamas58150.52109
French Polynesia55199.33190
Saint Martin371,035.08192
Sierra Leone354.4360

Table 3, continued

LocationConfirmedCases per 1 million peopleRecoveredDeaths
New Caledonia1863.78140
Saint Lucia1583.9400
Central African Republic122.1840
Åland Islands11368.08
Falkland Islands (Islas Malvinas)1120
The Gambia104.2621
Vatican City820
Papua New Guinea70.7800
Saint Barthélemy610
British Virgin Islands4133.221
South Sudan40.3100
Bosnia and Herzegovina

Source: Data December, 2019- April, 20, 2020; Corona virus (COVID-19)Map[COVID-19-map/hl=en[Accessed April, 20, 2020]and Wikipedia].

Coronavirus disease 19 outbreak has affected many of the countries worldwide. A total of 1,617,191 populations were vulnerable with active cases of COVID-19 cases. Among those active cases, the majority 1,562,980 (97%) cases were in mild condition and 54,211 (3%) active cases were at serious or critical condition (Fig. 3).

A total of 790,276 people were affected with closed cases which had an outcome globally. The majority, 625,202 (79%) were recovered from the temporary waiting areas, public health emergency centers, hospitals, health centers, and isolation areas and 165,074 (21%) died from a total of closed cases (Fig. 4).

During this systematic review; under management process or active cases 1,617,191 (77%), deaths 165,074 (7%), and recovered clients 625,202 (26%) had accounted from the the total 2,407,467 confirmed cases of COVID 19. The disease outbreak is undergoing a serious condition which showed that there are more than 892 new cases, greater than 43 new deaths, 309 a total cases/1 million population, and 21.2 deaths/1million population from December 2019 up to April 20, 2020 (Fig. 5).

Figure 5.

The total COVID-19 confrimed cases, deaths, recovered and under management process at isolated area, and rehabilitation area from December, 2019 to April, 20, 2020. Sources: Worldometers., 2020. COVID-19 CORONAVIRUS PANDEMIC Last updated: April 20, 2020, 05:27 GMT

The total COVID-19 confrimed cases, deaths, recovered and under management process at isolated area, and rehabilitation area from December, 2019 to April, 20, 2020. Sources: Worldometers., 2020. COVID-19 CORONAVIRUS PANDEMIC Last updated: April 20, 2020, 05:27 GMT


This review suggested that the awareness of the community and healthcare providers on COVID-19 prevention and control methods and its implementations is lower than other public health problems. Moreover, lack of public health emergency and access to vaccine and medication for appropriate management of COVID-19 outbreak in the world is a serious and growing emergency problem for the community equivalent for the growing more than millions of developing and developed in the world.

This study review, the research team members conclude the results clearly and briefly related to the key relevant literature to the findings of the 20 selected relevant articles based on selection criteria. Almost all reviewed studies were reported from December 31, 2020, to April, 19, 2020. Most (55%) of the analysed research articles were studied in China. This indicated that there were about 44 pneumonia cases with unknown etiology in Wuhan City, Hubei Province of China between December 31, 2019, and January 3, 2020. Meanwhile, after one week of duration, the National Health Commission China was reported to the WHO that the epidemic disease outbreak is rised with contacts in single seafood market in Wuhan City. However, the Chinese government were also confirmed as a new COVID-19 epidemic from the infected individual since January 7, 2020 [38].

This section (1) discusses the features of COVID-19; SARS-CoV-2; (2) describes magnitude of public health importance and controlling mechanisms of this disease; (3) rising the potential effects of a response to health emergencies, prevention and control methods of COVID-19; (4) describes instruments used to measure causes of COVID-19; (5) identify the level of risk prevention and control methods of COVID-19; furthermore, (6) the result of prevention and control mechanisms of COVID-19.

The scholars identified 20 studies, the majority of 6 (30%) indicated the vulnerability of patients and health professionals with COVID-19 and investigate the clinical outcome of patients. Similarly, a study was conducted in Italy by [34] suggested that the newly pandemic diseases outbreak, COVID-19 has threatened the health status of the communities, transportation systems, and trading and business activities including overall commerce in world countries including Italy. Moreover, the epidemiologic and demographic characteristics of previous SARS-CoV-01, MERS-CoV viruses, and experience of an emergency physician in the country’s were supported to identify the causes and complications of COVID-19 in order to address the issues of COVID-19 [34]. Nonetheless, the reviewed studies showed that most of the world countries have a lack of investigation kits for the diagnostic evaluation of COVID-19 and skilled professionals which related to new cases of COVID-19. As a result, most of the communities are died due to a lack of early diagnosed their cases and very difficult to differentiate the pathological characteristics of the virus and it might be increased the mortality rate of the population in the world nations. In similar with a study conducted in Fujian, China by Yaqian et al. (2020) found that the pathological features of COVID-19 have greatly similar with SARS due to observing symptoms of acute respiratory diseases syndromes; but the latest pathological examination of COVID-19 exposed the clear mucinous secretions in the lungs. Therefore, still, it needs early recognition of COVID-19 by health professionals and all expertise.

This research showed that the majority of reviewed studies were focused on the importance of emergency response such as quarantine, isolation, the distance between persons and other prevention and control methods for COVID-19 in various countries as well as key information about the meaning of COVID-19, way of transmission, causes and epidemiologic characteristics, management and ways to prevent and control it. However, there is an increasing number of confirmed cases and deaths in both developing and developed countries. Especially, there is increasing socioeconomic crisis and social interaction. This supported by world health Organization recent report 29, February 2020 found that the application of travel, and import and export system as such trade restrictions to world countries experiencing COVID-19 outbreak has been started to implement in the world continents. However, it is ineffective especially outcomes of social and economic effects, productivity, the resource used for intervention, and all other growth and development stages of every country in the world [37, 38].

Similarly, the study conducted in China by [37] agreed that the implementation of a Public Health Emergency of International Concern which was declared by the World Health Organization since after first cases of COVID-19 outbreak happen in China. The Implementation of prevention and control strategies like wearing masks, washing hand using soap and sanitizers for effective hand hygiene care practices, spacing the contact between individuals in order to avoid the public contact, early diagnosis and overall case detection, contact tracing, and quarantines were a most effective way to reduce COVID-19 transmission [37]. This review indicated that the implications for the importance of improving the work environment to increase awareness of health care providers and all communities on the way how to slow COVID-19.

The review revealed several carefully developed instruments and analytic approaches for measuring the level of risk, effects response to potential health emergencies, prevention, and control methods COVID-19. While these measures were developed for a specific study, a brief report and laboratory investigation official cases to identified confirmed diagnosis of COVID-19; SARS-CoV-2 outbreak and to address the research questions, which accounted for 6 (30%) of the level of risk, the effects a response to potential health Emergencies, prevention, and control method of COVID-19 outbreak measurements, was the most used strategy.

The reviewed study also showed that there was a lack of great attention to COVID-19 and it was very limited in some of the vulnerable countries and other territories. Therefore, six studies identified confirmed diagnosis of COVID-19; the SARS-CoV-2 outbreak. In this regard, there was declining the maximum number of new cases confirmed in China and it is relatively low in some cities of the country. It indicated that the lesson learned could help to control the outbreak of diseases in the world countries. Moreover, all tested results from 35 specimens were negative. This instrument can provide a useful stepping stone for the further study of slow COVID-19 [39].

In some studies, the measures were taken as part of an instrument; however, it is important to use them as measures to identify the level and risk response to Emergency public health and prevention and control method of COVID-19 outbreak and to better understand health professionals and communities towards how to prevent and to control COVID-19 transmission. Furthermore, it is also helpful to investigate the method of response to emerging public health for COVID-19. In similar with this review, a world health organization draft report (February 3, 2020) suggested that an instrument as such strategic preparedness and response plan was used to stop further transmission of COVID-19 within China and to other world nations and it was critical and important instruments to mitigate the common impact of COVID-19 outbreak in all countries [38, 39].

The majority of these reviewed studies utilized brief reports and laboratory investigations with including official confirmed COVID-19 case approaches to answer the research questions. Meanwhile, a few studies were using an online survey, a summary of experience, and longitudinal Cohort method which helps to collect, analyze, and interpret data. They used this method to assess the phenomenon, process, perspective, and views of health care providers and communities as well as governments, policymakers, and other stakeholders. Half of the reviewed studies, however, used various methods to address the research question as such situational analysis, clinical assessment and epidemiological survey, descriptive cross-sectional study, and an interventional plat for PPE task forces, simulation, and model approaches. A quality score based on respondents’ opinions within the reviewed studies using a standard form was used to obtain information according to the study design. The majority of reviewed studies frequently used situational and response-based analysis, descriptive and logistic regression, and follow up accompanied by use channels to compute study variables and socioeconomic characteristics including the final result of their studies [38, 39].

This review findings showed that elders age group and most of the vulnerable groups were the new migrants and journey related cases groups as well as people who are suspected and prone with COVID-19 and related to pandemic disease outbreaks. Similarly, the study was conducted in European countries, the COVID-19 related risk infection for people is higher in older adults groups in EU/EEA and UK [40].

This review study result showed that the capacity to prevent, investigate, and control the COVID-19 outbreak is different from country to country. This indicated that they have a wide variety of methods for slow COVID transmission. In similar, a study was conducted in the UK [41] found that traditional public health prevention and control methods are effective to reduce the maximum number of diseases outbreak, morbidity and mortality rate globally if the countries will have good opportunity to implement appropriately but not fully contain the outbreak of COVID-19. It supported by [42] quarantine, especially completed social distancing has been implemented to slow down the spread of the Coronavirus outbreak (COVID-19) in the USA and many other European countries next Italy [41, 42].

The finding also revealed that most of the confirmed cases and patients infected with COVID-19 infection pandemic diseases outbreak and having severe symptoms had lower lymphocyte counts and higher plasma levels and other laboratory test results. In similar, a study was conducted in the USA by [43] suggested that the impact pandemic COVID-19 outbreak on clinical microbiology laboratories was very high. Therefore, the rapid and accurate diagnosis and monitoring of SARS-CoV-2 infections and greatly assist in the control of this disease outbreak has been implemented using a combined device existing at the point of care with accessible measurements [43].

The review study suggested that in the first week of the COVID-19 outbreak occurred in China, the majority of the health care providers were administered blood transfusion as emergency care and there was a significant changed via the result of a safe life. Similarly, WHO has been adopted Guidance for National Blood Services on Protecting the Blood Supply During Infectious Disease Outbreaks [44, 45] and risk assessment publications on pandemic COVID-19 outbreak from continental, regional networks and any higher institutions and health sectors [46, 47, 48].


Even though the novel COVID-19 outbreak on 31 December 2019 in Wuhan, Hubei city, China, and worldwide countries, there are normally relevant studies to determine the risk and impact of response to a public health emergency, prevention, and control methods of COVID-19 to slow transmission on countries with armed. The finding showed that there has been an unprecedented rapid spread of pandemic COVID-19 outbreak across 212 countries with greater than 1.1. million confirmed cases and more than 100,000 deaths worldwide as of 20, April 2020. Therefore, each country’s government should be drawn alongside to prevent and control of pandemic COVID-19 outbreak. Moreover, the world continents public health emergency responses with valuable support from the community, health professionals and governments must be needed to discuss upon the way to slow COVID-19 transmission and other related action to pandemic diseases.

The WHO has been declared the COVID-19 outbreak constitutes a public health emergency of international concern since 30, January 2020, the nature of the COVID-19 outbreak might be changed to pandemic level due to increasing transmission, magnitude, severity, morbidity, and mortality rate across the world Nations. Therefore, all governments should create strong partners and came to collaboration joint activities using global outbreak prevention and control policy to respond to the COVID-19 emergency and decrease numbers of cases and deaths in world continents.

Now a day, there are no any existing and available medicine for the treatment of COVID-19; SARS-CoV-2 outbreak and still lack of the effectiveness of potential therapeutic agents for other diseases outbreaks as such Ebola and SARS-01 and MERS Coronavirus caused respiratory problems, however, they have a little evidence to manage the symptoms which related to previous viral endemic and pandemic diseases outbreak. Hence, there is increasing a probability of COVID-19 transmission among the world communities and the impact of the diseases in world nations.

The reviewed study finding revealed that almost all continents have no pre-existing immunity in the population against the new COVID-19 and anybody in the communities is implicit to be vulnerable for this disease outbreak. This is an issue for world communities and higher to kill all populations; therefore, international, national, regional, and local donors should have an important role to play in mitigating the economic impacts of COVID-19) outbreak. Moreover, a combination of strong country governance, strict rules and regulation, strong health care providers and community awareness and citizen involvement, and wise use of big COVID-19 row data and digital technologies are very important to form the basic foundation of mitigation and curative measures of a disease outbreak. The implications of this review study are significant in certain areas of the COVID-19 outbreak which worth further research.

Moreover, the research team concluded that future research must look at the risk and impacts of a various public health emergency, prevention, and control methods of COVID-19 outbreak and other epidemic and pandemic diseases around the world. Moreover, it must be respected to incubation periods, how drug synthesized, vaccine sources and effectiveness and frequency, the effect of a public health emergency, the impact of COVID-19 on each country’s economic, social and environmental growth and development including overall crisis, community health status, and personal and professional skill development to slow COVID-19 transmissions.

Therefore, the optimal duration and frequency of this response on public health emergency to prevent and control of COVID-19 and to create positive impacts can be verified. In addition, it is valuable to investigate which types of responses of public health emergency to prevent and control of COVID-19 outbreak effects and which are more targeted. As a result, hand washing with sanitizers, the distance between individuals, call for health professionals, quarantine, isolation, and overall precautionary measures and critical awareness of health care providers and communities to slow COVID-19 transmission can be designed accurately and effectively.

The effect of quarantine especially home quarantine, school closure, and another early warning as a public health emergency to prevent and control of COVID-19 pandemic outbreak transmission was regarded as a positive outcome, but it needs to be implemented with precaution. Therefore, we recommended that the use of various measurements of slow COVID-19 pandemic disease outbreak for comparison of outcomes in future researches.


The authors are grateful to Salale University, Fitche, Ethiopia for the material support. The authors are also highly acknowledged by all scientific researchers and scientists, the World Health Organization, the Centre for Disease Prevention and Control; the Ministry of Health, and all individuals who render valuable technical during the study period.



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