The level of risk, effects response to potential health emergencies, prevention and control method of COVID-19: A systematic review

1.Background

Coronavirus had been observed to cause epidemic diseases since 2003, and it has also caused many community health problems that resulted in globally serious issues. Moreover, these cases consecutively occurred as a severe acute respiratory syndrome (SARS), middle east respiratory syndrome (MERS), and Coronavirus disease 2019 (COVID-19) [1]. There is a new community health problem threatening the globe with the emergence and spread of COVID-19 or the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The virus started in bats and was transmitted to humans through as yet unknown intermediary animals in Wuhan, Hubei province, China in December 2019 [2].

COVID-19 is basically transmitted by respiratory droplets and close contact. Pulmonary function testing procedures have been associated with an increased risk of COVID-19 transmission from clients and health professionals [3]. The changing transmission situations, specifically, nosocomial transmission and spread through mildly symptomatic cases, is a range of concern. There is a range of signs and symptoms from mild to serious disease with major complications such as severe pneumonia, ARDS, acute cardiac injury and septic shock. Bilateral ground-glass opacity and consolidation on imaging with possible clinical features should raise a suspicion about COVID-19. Destitute prognostic regions such as multilobular infiltration on chest imaging, lymphopenia, bacterial co-infection, smoking history, chronic medical conditions like hypertension, and age > 60 years (MuLBSTA score) [4]. The COVID-19 outbreak that started in Wuhan, Hubei province, China on 31 December, 2019 is now a pandemic with > 100,000 cases and 3,000 deaths reported in 93 countries as of 07 March 2020. One COVID-19 infection report describes a 64-year-old man who developed rapidly worsening respiratory failure and acute respiratory distress syndrome (ARDS) that required intubation. As the clinical spectrum of COVID-19 ranges widely from mild illness to ARDS with a high risk of mortality, there is a need for more research to identify early markers of disease severity [5].

The Chinese authorities restricted some travel in an attempt to stop the illness from 23 January 2019 and China’s financial markets remained closed until Monday 03 February 2019 after authorities extended the Lunar New Year holiday break by three days. The disease then rapidly spread all over the world. The WHO then declared this disease a pandemic on 11 March 2020.

A cluster of patients with pneumonia of unknown cause was linked to a seafood wholesale market in Wuhan, China. A previously unknown betacoronavirus was discovered through the use of unbiased sequencing in samples from patients with pneumonia. Human airway epithelial cells were used to isolate a novel coronavirus, named COVID-19 which formed a clade within the subgenus sarbecovirus, orthocoronavirinae subfamily. Different from both MERS-CoV and COVID-19; SARS-CoV-2 is the seventh member of the family of coronaviruses that infect humans. Enhanced surveillance and further investigation are ongoing (Funded by the National Key Research and Development Program of China and the National Major Project for Control and Prevention of Infectious Disease in China) [6].

Data are lacking on the impact of Middle East Respiratory Syndrome (MERS) on health-related quality of life (HRQoL) among survivors. Functional scores were similar for MERS and non-MERS SARI survivors. However, MERS survivors of critical illness reported lower quality of life than survivors of less severe illness. Efforts are needed to address the long-term medical and psychological needs of MERS survivors [7]. The first Chinese data published seem to show that the symptoms in pregnant women are the same as those of the general population. There are no cases of intrauterine maternal-fetal transmission, but cases of newborns infected early suggest that there could be vertical prepartum or neonatal transmission. Induced prematurity and cases of respiratory distress in newborns of infected mothers have been described. Pregnancy is known as a period at higher risk for the consequences of respiratory infections, as for influenza, so it seems important to screen for Covid-19 in the presence of symptoms and to monitor closely pregnant women. In this context of the SARS-Covid-2 epidemic, the societies of gynecology-obstetrics, infectious diseases, and neonatology have proposed a French protocol for the management of possible and proven cases of SARS-Covid-2 in pregnant women [8].

Predicting the number of new suspected or confirmed cases of COVID-19 is crucial in the prevention and control of the COVID-19 outbreak. Social media search indexes (SMSI) for dry cough, fever, chest distress, coronavirus, and pneumonia were collected from 31 December 2019 to 9 February 2020. The new suspected cases of COVID-19 data were collected from 20 January 2020 to 09 February 2020 [9].

The COVID-19 pandemic is first and foremost a humanitarian crisis. Efforts to contain the virus and support those directly impacted are of utmost importance. The COVID-19 pandemic is an unprecedented global shock that magnifies the impact of inequality, hitting the poor the hardest. In developed countries, frontline workers in the service economy are among the most exposed to the virus and the least able to absorb its financial impact. The hardest hit will be the poor in developing countries, where already-struggling workers will not have the benefit of social safety nets and stimulus packages. The G7 and G20 must immediately help these countries to finance the flattening of the pandemic curve. Longer-term, we must redouble efforts to foster sustainable economic systems, including fair trade and investment [10].

Awareness and attentiveness have implications for the acceptance and adoption of disease prevention and control measures. Social media posts provide a record of the public’s attention to an outbreak [11]. The effect of corona discharge-generated air ions on the filtration of aerosolized bacteriophage MS2 was studied. A carbon-fiber ionizer was installed upstream of a medium-efficiency air filter to generate air ions, which were used to charge the virus aerosols and increase their filtration efficiency. After the virus aerosols were captured by the filter for a certain time interval, they were exposed to a new incoming air ion flow [12].

The emergency that the world faces today demands that we develop urgent and effective measures to protect people at high risk of transmission. WHO has accelerated research in diagnostics, vaccines, and therapeutics for this novel Coronavirus [13]. The aim of this review study is to identify and review a published level of risk, effects response to potential health emergencies, prevention, and control method of the COVID-2019 outbreak. This review will serve to provide well-organized information for the global community in this regard.

2.Method

The method was used to asses level of risk, effects response to potential health emergencies, prevention, and control method of Coronavirus disease 19 from published and unpublished works worldwide. The following procedures are used in this review; choosing appropriate research objective and search strategies; collecting important articles; choosing research articles; extracting and recording of data; finally, summarization, discussion, analyzing, and reporting the results were conducted.

3.Literature search strategies

A systematic review was performed after literatures were identified by searching the following online databases: medRxiv, Google scholar, PubMed, MEDLINE, EMBASE, and the Cochrane Library with supplementary hand searching for conferences. The online databases contain archives of most English biomedical journals. Additionally, Scientific papers published online by the Center for Disease Control and the WHO and reputable organizational recognized websites from health sectors and other related sectors and /organizations were included.

This strategy was utilized to decide the precision of the results by comparing them within the related articles from different reputable and key important sources. The review is based on peer-reviewed journal articles on “level of risk, to potential health emergencies, “effects response to potential health emergencies, and prevention and control methods” that were published from 31 December 2019 to 20 April 2020. This time span was chosen because the current diseases outbreak and its up-to-date information is important to justify and address the objective of the review articles. The ‘COVID-19’, ‘2019 novel coronavirus’, ‘2019-nCoV’, ‘novel coronavirus, and ‘Pneumonia’ key search terms were used in this review.

Firstly, all searched articles using inclusive criteria were assessed, then after assessing all titles and content of the articles, the value of the articles to address the aim of this study was assumed, and examined. The terms used for searching related articles were “potential health” “emergencies”, “prevention”, “control”, “Coronavirus-2019” pandemic diseases”, “viral infections”. Also “risk and effect response” and “emergency preparedness” were used together to search the articles from different key relevant databases and official governmental and nongovernmental websites including reports.

The investigators have used the Effective Public Health Practice Project Quality Assessment Tool (EPHPP) (EPHPP, 2020) to assess the quality of quantitative research in this review. This instrument had ordinal scoring for the following components: selection bias, study design, confounders, blinding, data collection methods, withdrawals and dropouts. It helps to assess review study quality and develop recommendations for study results. Each component was rated strong, moderate, or weak, and these ratings were also combined into a global quality rating (strong, moderate, or weak). Two reviewers assessed the quality, and discrepancies were resolved by discussion.

3.3Prisma flow diagram

The research team has searched a total of 132 articles. The titles, summary or abstract, and the whole body of each article were then checked for their relevance and suitability to be included in the analyses. Finally, a total of 20 articles were found to be eligible [Fig. 1].

Figure 1.

PRISMA Diagram (Source: Moher, D., Liberati, A., Tetzlaff, J., Altman, DG. The Prisma group (2009). Preferred/Reporting/ Items for systematic Reviews and Meta-analysis: The Prisma Statement.PLOs Med, 6(7): e1000097. dpi: 10.137/journal.pmed10000097).

4.Results

From the total of 20 reviewed studies, 11 (55%) were conducted potential health emergency, prevention, and control methods of COVID-19 outbreak COVID-19 in China in 2020. This indicated that almost all (100%) of the studies were employed from 31 December 2019 and 13 April 2020. Among those, 11 (55%) researches were conducted in China [16, 18, 20, 21, 22, 23, 28, 29, 30, 32, 33]. About 3 (15%) researches were studied in the USA [17, 26, 27]. The remaining studies (30%) were conducted in Brazil (5%), Switzerland (5%), California (5%), Korea (5%), Hong Kong (5%), and India (5%) respectively [14, 16, 19, 24, 25, 31]. The ocurance of pandemic COVID-19; SARS-CoV-2 outbreak situation starts from Wuhan, Hubei city, China and transmitted to world countries with diseases manifest itself for all communities without age, gender, ethnicity, religious, position, authority, education, occupation, country, regions, richness, poorness, and color differences among the world population. Eleven of twenty reviewed studies were conducted, suspected cases and deaths reported as well.

Among 20 studies, 6 (30%) studies analyzed the vulnerability of patients and health professionals with COVID-19 and investigate the clinical outcome of patients with moderate type of COVID-19 after discharged by retesting viral nucleic acid, the epidemiological charactesrtics and dynamics of confirmed COVID-19 cases related with the transmission in Incubation periods of first cases, transmision and its association with population emigration [14, 25, 28, 29, 32, 33] and, followed by 4 (20%) studies analyzed the development of institutional algorism to protect operating-room team members during the COVID-19 pandemic and rationally conserve personal protective equipment, the incidence of COVID-19 infection among people under home quarantine and its effectiveness and great attention of a pre-established nationally representative Cohort of Weibo user was searched for COVID-19 related key words in their posts [19, 20, 23, 25].

About 3 (15%) studies analyzed the effectiveness of the school closure effects on the COVID-19; SARS-COV-2 outbreak, the public health investigation of a mildly ill, non hospitalized COVID-19 case who traveled to China and how the healthcare provider can support all communities to relieve existing health security capacities against public health risks and events [15, 24, 26], 2 (10%) studies analyzed the available evidence about COVID-19 and the International community with a deeper understanding of this new infectious diseases [16, 31], 2 two studies (10%) analyzed the investigating the content of You-tube videos related to COVID-19 gaps in the current knowledge and the incidence of 2019-nCoV infection among people under home quarantine [23, 27].

The remaining 3 (15%) studies analyzed the response from various health sectors as such district to generalized hospitals, private and public hospitals, health centers, clinics, and temporary emergency response centers including all other sectors waiting area, the regional blood center, and the hospital-based transfusion services to the events that took place in the community phases of COVID-19 pandemic [17].

The role of the newly established and technological product of internet hospitals during the prevention and control of Novel 2019 infectious pandemic diseases outbreak (COVID-19; SARS-CoV-2) [21], and importance and the main role of community pharmacists’ including the content of pharmaceutical care to slow transmission of COVID-19 [22]. Moreover, the review study was focused on the importance of emergency response such as quarantine, isolation, the distance between persons and other prevention and control methods for COVID-19 in various countries as well as key information about the meaning of COVID-19, way of transmission, causes and epidemiologic characteristics, management and ways to prevent and control it.

The majority of the reviewed articles (65%) selected a sample size between 1 and 400 [14, 15, 16, 19, 22, 25, 26, 27, 28, 29, 31, 33], and followed by 5 (25%) studies were selected a sample size ⩾ 1200 [21, 23, 25, 30, 32]. Meanwhile, 1 (5%) study selected samples between 801 and 1200 peoples [17], and the other 1 (5%) study selected samples between 401 and 800 [18] [Fig. 2].

Figure 2.

Total number of sample size of the reviewed articles.

In this review, 6 (30%) findings utilized a brief history and laboratory examination official cases to identified confirmed diagnosis on COVID-19; SARS-CoV-2 outbreaks and to answer the research questions [17, 26, 29, 32, 31, 33].

Three (15%) of the studies used a situational analysis in order to address the reviewed questions [14, 15, 25], and 3 (15%) studies used an interventional platform PPE taskforce, developed model and simulation study to address review questions [19, 20, 24]. Only 2 (10%) of the research articles used clinical examination and epidemiological study to answer review questions [16, 28] and 2 (10%) studies used descriptive cross-sectional study [23, 27]. The remaining 4 (20%) studies used an online survey (5%) [18], a summary of experiences 3 (5%) [22], online epidemic related consultants (5%) [21] and longitudinal Cohort 3 (5%) [25] to address review questions.

This review had to generalize results from the mentioned articles by identifying a wide variety of the level of risk, effects response to potential health emergencies, prevention, and control methods COVID-19 that might prevent and control the transmission of the infectious pandemic outbreak disease in world nations. These results show the different instruments used to measure the level of risk, effects response, and overall characteristics of COVID-19. Operation room, guideline, well mixed SEIR model, laboratory results, endoscopes, interventional suites and other devices like ‘multicenter internet hospitals’, which accounted for 55% of articles on response to potential health emergencies, prevention and control method of COVID-19 was the highly ranked used strategy [19, 21, 20, 23, 24, 26, 27, 28, 30, 31, 33].

It was followed by 5 (25%) studies list of the hospitalized patient with COVID-19 and the daily number of new confirmed cases [14, 16, 25, 29, 32]. The remaining 4 (20%) studies State Party Annual Reporting (SPAR) tools (5%) [15], blood supply and transfusion units (5%) [17], patient pharmaceutical care and drugs and other supplies (5%) [22], and the depression, anxiety, and stress scale and the impact of event scale revise (5%) [18]. About 4 (20%) of studies were analyzed using situational analysis and response-based analysis to identify the result of the reviewed study [14, 17, 22, 28], and followed by 3 (15%) studies descriptive and logistic regression [21, 23, 29], and 3 studies (15%) follow up and busing channels [25, 27, 33] whereas 2 (10%) studies were using clinical features and treatment of COVID-19 [16, 26], 2 (10%) studies indicated the epidemic curve of the period over the period growth rate of the new confirmed cases [30, 31]. The remaining 6 (30%) studies used various analysis methods to identify the problem and its alternative solution, transmission parameters (5%) [24], Baidu Qlaux and Correlation ArcGIS and Win Bugs software (5%) [32], Six Geographic WHO regions (5%) [15] (Kandel et al., 2020), psychological impact and mental status (5%) [23], Considering infected individuals as contagious during the latency period (5%) [20] and develop guideline, health policies and other legislation (5%) [19].

In this review, 6 (30%) studies used a systematic way of assessing the community and healthcare providers’ awareness and beliefs on COVID-19 transmission, prevention, epidemiologic charactesrtics, management and how to implement WHO prevention and control protocol and its purpose to slow COVID-19 transmission [16, 17, 22, 25, 27] followed by 4 (20%) studies which assessed and identified the vulnerability of a community contact with suspected and confirmed COVID-19 cases and evaluate its epidemic outbreaks [14, 21, 26, 31] and 4 (20%) studies assessed the main target-related prevention and control, detection, enabling, emergency responses, operational readiness, and public health emergency including efficient and effective hand washing practices [15, 24, 28, 29].

In addition, 3 (15%) studies detected how we can develop the common algorism for the majority part of COVID-19 transmission methods by using various personal protection equipment and well mixed SEIR Model in order to identify the new case of COVD-19 and how we can control the speed of transmission [19, 20, 25], and 3 (15%) studies calculated the incidence and basic characteristics of the pandemic COVID-19 outbreak [23, 32, 33] [Table 1].

In this review, 4 (20%) studies an intervention was focused on older age groups and new migrants and journey-related case groups and/or suspected vulnerable grous [14, 25, 31, 32] followed by 4 (20%) studies suggested that most of the time, infected patients with the COVID-19 infection and having severe symptoms had lower lymphatic counts and higher plasma level of Pt, APTT, D-dimer, LDH, PCT, ALB, CRP, and AST and other laboratory test results [16, 26, 28, 33].

Group transmission has been one possible way to transmit COVID-19 from one area to another since 23 March 2020. The evidence showed that the number of expected cases are lower depending on the time of quarantine and it may change the incidence of COVID-19 in children from 28.4 to 33.6 for 7 and 14 days [24, 25], and pharmaceutical effects were one vital management system for COVID-19 but there is still no effective medicine to manage COVID-19 or vaccine to protect transmissions [22, 23].

About 2 (10%) studies identified that the capacity to prevent, investigate, and control COVID-19 varies from country to country, which indicates a wide variety of implementation of control methods to slow COVID transmission [15, 20]. The finding showed that the world communities are vulnerable to COVID-19 and rated the psychological and mental impact from moderate to severe stages [23, 25]. The remaining 4 (20%) studies showed that a decision-tree algorism is used to describe the health institution guideline for actioning any precautions for all departments and most of the time, operation-room team members [19], emergency-based treatments like blood transfusions are a significantly observed treatment for COVID-19 in the first week of the disease outbreak occurring in China [17].

Most of the reviewed studies results showed that the case fatality and the incidence of COVID-19 was 22% and 8-65/1000000, respectively [29] and fewer than one-third of the videos covered any of the seven key prevention behaviors listed on the United States Centers For Diseases Control and Prevention websites [27].

The review showed that COVID-19; SARS-CoV-2 is one of the most killer diseases of global communities and it needs urgent public health emergency to slow transmissions. Therefore, this review was identified as various problems related to COVIOD-19 and its conclusion. Six (30%) of studies suggested that there is a shortage of community and healthcare-provider awareness and lack of training for health professionals related to the psychological and environmental impact of COVID-19 [14, 20, 25, 26, 27, 28], and followed by the epidemic prevention and control measures taken by the state and government at all level of health shown very significant effects [29, 30, 31, 32]. In another way, 3 (15%) of studies agreed that the implementation of efficient and effective potential health emergency response are critically important to slow COVID-19 transmission from person to person in world nations [15, 18, 22].

The remaining 7 (35%) studies suggested that the possibility of massive transmission in the children’s age group is lower [24], there is a relatively high incidence of positive viral nucleic acid in patients who met the ‘discharge from hospital’ criteria [33], some of the viral pneumonia cases were treated with scientifically approved traditional Chinese medicine and other drugs like Kaletera as combination form [16].

Moreover, around the globe, most of the district to specialized hospital activities have been switched from day to day activities and operations to COVID-19 and overall, people and routine activities are highly disrupted in both developing and developed countries [17, 21]. There is also agreement that internet hospitals can serve various kinds of endemic, epidemic, pandemic and sporadic diseases outbreaks, and offer special to the community at the time of the COVID-19 outbreak and lower psychological impact of the COVID-19 [18] including ensuring optimal healthcare workers safety are vital to slow COVID-19 transmission [19].

Seven (35%) of the studies reviewed recommended that mass quarantine and isolation action must be given great attention by government and communities [14, 18, 20, 27, 28, 29, 31] because it helps to slow COVID-19 transmission and decrease the morbidity and mortality rate in both low, middle and high-income countries. Five (25%) studies suggested that currently, COVID-19 is one of the most serious public-emergency and life-threatening problems; therefore facilitating the epidemiology screening and proactive communication of early warning in transparent manners and behaviors [16, 21, 25, 30, 32]. Two (10%) studies recommended that formulating psychological management and follow-up, including viral testing, should be implemented to identify the severity, magnitude, negative and positive result and/or confirmed cases and total death of the COVID-19 infected persons [18, 33]. The remaining 6 (30%) studies indicated that capacity building and collaboration between countries is critically important (5%) [15]. Further studies related to newly proved combined medication like Kaletera and Chinese traditional medicine in the treatment of COVID-19 is advisable [16].

For emergency care, blood transfusion and the utilization of existing supportive managements it healthcare providers are encouraged to take precautions before, during and after operating room activities [19], prepare a community-based pharmacy [22] and the state and government should develop various health and health-related models and simulations are the most commonly advised recommendations to slow COVID-19 transmission across the world [24] [Table 2].

4.1Confirmed Cases, Recovered and Deaths due to Coronavirus Disease 2019

The reviews indicated the highest confirmed COVID-19 cases, 764,177 patients were registered from the USA starting from the onset of the disease up to 13 April 2020, and followed by Spain accounted 198,674 confirmed cases. However, the lowest COVID-19 confirmed cases, only one case was reported in Yemen, and still, nothing COVID-19 cases and deaths occurred in Bosnia and Herzegovina or Antarctica. Regarding deaths, the most deaths, 40,591 were registered in the United States and followed by 23,660 deaths in Italy, 21,238 in Spain, 19,718 in France, 16,060 in the United Kingdom, 5,683 in Belgium, 5,118 in Iran, 4,632 in China, 4586 in Germany, 3,684 in Netherland, 2,462 in Brazil, 2017 in Turkey, 1,587 in Canada, 1,540 in Sweden, 1,393 in Switzerland and the lowest rate of deaths it means the countries which had registered only one death per their confirmed COVID-19 cases from December 2019 up to 13 April 2020 were reached 15 (Burundi, Burundi, Gabon, Liechtenstein, Cape Verde, cayman islands, Libya, Benin, Botswana, Curacao, British version Islands, Suriname, the Gambia, and Mauritania) [34].

However, a total of 39 countries: Rwanda, Gibraltar, Cambodia, Madagascar, Reunion, Vietnam, Faroeisland, FrenchIslands, French Guinea, French Polynesia, Uganda, Maldives, Macao, Eriteria, Mozambique, Sierra Leone, Chad, Mongolia, Nepal, Timer-Leste, Laos, New Caledonia, Fiji, Dominica, Nambia, Saint Lucia, Saint Barthelemy, Falkland Island (Islas Malvinas), Green lands, Monsterrat, Seychelles, Vatican city, Papua New Guinea, Bloutan, South Sudan, Anguilla, and Yemen have had not any death (Zero Death Number) from their registered total number of confirmed cases as active and closed cases of COVID-19. The result also showed that there was no death report within 11 confirmed cases it means that either zero, one, or more deaths registered in the Aland Islands [33, 34] [Table 3].

Table 3

Total confirmed cases per 1 million people, recovered and deaths due to Coronavirus Disease 2019

Location	Confirmed	Cases per 1 million people	Recovered	Deaths
Worldwide	2,402,076	308.92	623,911	165,106
United States	764,177	2,318.81	70,172	40,591
Spain	198,674	4,218.1	77,357	21,238
Italy	178,972	2,970.81	47,055	23,660
Germany	145,184	1,746.06	83,438	4,586
United Kingdom	120,067	1,807.27	–	16,060
France	112,606	1,678.78	36,578	19,718
Turkey	86,306	1,037.89	11,976	2,017
China	82,747	59.02	77,084	4,632
Iran	82,211	986.56	57,023	5,118
Russia	42,853	292.02	3,291	361
Brazil	38,654	182.9	14,026	2,462
Belgium	38,496	3,340.38	8,757	5,683
Canada	35,056	923.03	11,843	1,587
Netherlands	32,655	1,871.24	–	3,684
Switzerland	27,469	3,199.07	17,800	1,393
Portugal	20,206	1,966.21	610	714
India	16,116	11.85	2,302	519
Peru	15,628	486.38	6,811	400
Ireland	15,251	3,098.85	–	610
Austria	14,710	1,652.33	10,501	452
Sweden	14,385	1,392.08	550	1,540
Israel	13,491	1,469.61	3,754	172
Japan	10,807	85.8	1,069	238
South Korea	10,674	206.14	8,114	236
Chile	10,088	527.97	4,338	133
Ecuador	9,468	542.37	1,061	474
Saudi Arabia	9,362	273.6	1,398	97
Poland	9,287	241.98	1,040	360
Romania	8,746	450.7	1,892	434
Pakistan	8,348	38.09	1,868	168
Mexico	8,261	65.26	2,627	686
Denmark	7,384	1,268.13	4,141	355
Norway	7,078	1,318.66	–	165
United Arab Emirates	6,781	685.61	1,286	41
Czechia	6,746	630.82	1,298	186
Australia	6,606	257.39	4,230	70
Singapore	6,588	1,155.06	768	11
Indonesia	6,575	24.63	686	582
Serbia	6,318	907.27	753	122
Philippines	6,259	57.69	572	409
Ukraine	5,449	130.11	347	141
Qatar	5,448	1,983.05	518	8
Malaysia	5,389	164.61	3,197	89
Belarus	4,779	507.68	494	47
Dominican Republic	4,680	451.81	363	226
Panama	4,467	1,058.83	165	126
Colombia	3,792	76.77	711	179
Finland	3,783	684.39	1,700	94
Luxembourg	3,550	5,782.76	627	73
South Africa	3,158	53.73	903	54
Egypt	3,144	31.38	732	239
Argentina	2,930	65.2	708	134
Morocco	2,855	79.62	327	141
Thailand	2,765	41.59	1,928	47
Algeria	2,629	61.14	1,047	375
Moldova	2,472	921.79	457	67
Bangladesh	2,456	14.59	75	91
Greece	2,235	208.4	269	113
Hungary	1,916	196.06	250	172

Table 3, continued
Location	Confirmed	Cases per 1 million people	Recovered	Deaths
Kuwait	1,915	433.25	305	7
Bahrain	1,881	1,218.82	762	7
Croatia	1,871	459	709	47
Iceland	1,771	4,861.91	1,328	9
Kazakhstan	1,676	89.75	401	17
Uzbekistan	1,565	45.89	225	5
Iraq	1,539	39.33	1,009	82
Estonia	1,528	1,150.29	164	40
Azerbaijan	1,398	138.87	712	19
Slovenia	1,330	635.13	192	74
Lithuania	1,298	464.65	242	33
Armenia	1,291	436.52	545	20
Oman	1,266	271.39	233	6
North Macedonia	1,207	581.09	178	51
Slovakia	1,161	212.78	229	12
New Zealand	1,105	222.11	974	12
Ghana	1,042	34.41	99	9
Cuba	1,035	92.33	255	34
Hong Kong	1,026	136.79	602	4
Cameroon	1,017	38.31	305	42
Afghanistan	993	30.81	131	32
Bulgaria	894	127.71	161	42
Tunisia	879	74.99	43	38
Côte d’Ivoire	847	32.8	260	9
Djibouti	846	784.52	102	2
Cyprus	767	875.67	79	12
Latvia	727	381.27	88	5
Andorra	713	9,194.9	235	36
Lebanon	673	98.6	99	21
Costa Rica	660	130.49	112	5
Niger	648	29.04	117	20
Nigeria	627	3.04	170	21
Guinea	579	47.39	87	5
Burkina Faso	576	27.6	338	36
Bolivia	564	49.17	31	33
Albania	562	197.47	314	26
Kyrgyzstan	554	84.79	133	5
Uruguay	528	150.06	298	10
Kosovo	510	284.02	93	12
Honduras	472	51.54	10	46
San Marino	461	13,730.86	60	39
Palestine	437	87.81	72	3
Malta	427	865.14	118	3
Taiwan	420	17.79	189	6
Jordan	417	39.16	276	7
Réunion	408	476.18	237	0
Georgia	394	105.82	86	4
Senegal	367	22.64	220	3
Mauritius	328	259.09	208	9
Democratic Republic of the Congo	327	3.65	26	25
Montenegro	308	494.89	55	5
Isle of Man	298	3,576.83	193	6
Mayotte	271	1,184.51	117	4
Sri Lanka	271	12.43	96	7
Kenya	270	5.68	67	14
Vietnam	268	2.79	202	0
Guatemala	257	15.48	21	7
Venezuela	256	7.95	117	9
Jersey	245	2,294.01	–	12
Guernsey	239	3,806.22	87	9

Table 3, continued
Location	Confirmed	Cases per 1 million people	Recovered	Deaths
Mali	224	11.22	42	14
Paraguay	206	28.8	41	8
El Salvador	201	30.99	44	7
Faroe Islands	185	3,549.23	176	0
Jamaica	173	63.45	27	5
Tanzania	170	3.04	11	7
Martinique	163	419.99	73	12
Guadeloupe	148	363.85	73	8
Rwanda	147	11.88	76	0
Republic of the Congo	143	25.91	11	6
Brunei	138	311.93	115	1
Somalia	135	8.49	2	7
Gibraltar	132	3,916.8	120	0
Cambodia	122	7.98	105	0
Madagascar	121	4.61	39	0
Myanmar (Burma)	111	2.04	7	7
Gabon	109	50.17	7	1
Ethiopia	108	1.09	16	3
Northern Cyprus	108	331.29	52	3
French Guiana	97	340.14	69	0
Aruba	97	863.69	49	2
Monaco	94	2,454.31	22	3
Sudan	92	2.17	8	12
Liberia	91	20.33	7	8
Bermuda	86	1,343.18	35	5
Togo	84	11.14	49	5
Liechtenstein	81	2,090.38	55	1
Equatorial Guinea	79	58.16	4	0
Barbados	75	261.3	19	5
Sint Maarten	67	1,649.68	12	9
Guyana	65	83.04	9	7
Cape Verde	61	110.81	1	1
Cayman Islands	61	926.87	7	1
Zambia	61	3.41	33	3
The Bahamas	58	150.52	10	9
French Polynesia	55	199.33	19	0
Uganda	55	1.36	20	0
Maldives	52	138.75	16	0
Libya	51	7.42	11	1
Guinea-Bissau	50	31.16	3	0
Haiti	47	4.06	0	3
Macao	45	66.22	17	0
Eritrea	39	11.15	3	0
Mozambique	39	1.3	4	0
Syria	39	2.23	5	3
Saint Martin	37	1,035.08	19	2
Benin	35	2.98	18	1
Sierra Leone	35	4.43	6	0
Chad	33	2.03	8	0
Mongolia	32	9.67	7	0
Nepal	31	1.03	3	0
Zimbabwe	25	1.65	2	3
Angola	24	0.77	6	2
Eswatini	22	20.12	8	1
Botswana	20	8.55	0	1
Timor-Leste	19	13.7	1	0
Laos	19	2.67	2	0
Belize	18	44.07	0	2
New Caledonia	18	63.78	14	0
Fiji	17	19.21	0	0
Malawi	17	0.89	3	2

Table 3, continued
Location	Confirmed	Cases per 1 million people	Recovered	Deaths
Dominica	16	222.82	8	0
Namibia	16	6.51	6	0
Saint Lucia	15	83.94	0	0
Grenada	14	125	0	0
Curaçao	14	88.24	11	1
Central African Republic	12	2.18	4	0
Åland Islands	11	368.08	–	–
Falkland Islands (Islas Malvinas)	11	–	2	0
Greenland	11	196.14	11	0
Montserrat	11	–	2	0
Seychelles	11	112.68	5	0
Nicaragua	10	1.55	6	2
Suriname	10	17.2	6	1
The Gambia	10	4.26	2	1
Vatican City	8	–	2	0
Mauritania	7	1.72	2	1
Papua New Guinea	7	0.78	0	0
Saint Barthélemy	6	–	1	0
Burundi	5	0.46	0	1
Bhutan	5	6.74	2	0
British Virgin Islands	4	133.2	2	1
South Sudan	4	0.31	0	0
Anguilla	3	201.76	1	0
Yemen	1	0.03	0	0
Bosnia and Herzegovina	–	–	–	–

Source: Data December, 2019-April, 20, 2020; Corona virus (COVID-19) Map google.com [COVID-19-map/hl=en[Accessed April, 20, 2020] and Wikipedia]

The Coronavirus disease 19 outbreak has affected many countries worldwide. A total of 1,617,191 people were vulnerable with active cases of COVID-19. Among those active cases, the majority 1,562,980 (97%) cases were mild and 54,211 (3%) active cases were in a serious or critical condition [Fig. 3].

Figure 3.

Total number of active cases of COVID-19 outbreak from 31 December 2019 up to 20 April 2020.

Figure 4.

Total number of closed cases of COVID-19 from December, 2019 up to 20 April, 2020.

A total of 790,276 people were affected with closed cases which had an outcome globally. The majority, 625,202 (79%) had recovered from the temporary waiting areas, public health emergency centers, hospitals, health centers, and isolation areas and 165,074 (21%) died from a total of closed cases [Fig. 4].

During this systematic review; under management process or active cases 1,617,191 (77%), deaths 165,074 (7%), and recovered clients 625,202 (26%) had accounted from the the total 2,407,467 confirmed cases of COVID 19. The disease outbreak is serious, showing that there are more than 892 new cases, greater than 43 new deaths, 309 a total cases/1 million population, and 21.2 deaths/1million population from December 2019 up to April 20 2020 [Fig. 5].

Figure 5.

The total COVID-19 confirmed cases, deaths, recovered and under management process at isolated area,and rehabilitation area from December 2019 to 20 April 2020.

5.Discussions

This review suggested that the awareness of the community and healthcare providers on COVID-19 prevention and control methods and its implementations is lower than other public health problems. Moreover, lack of public health emergency and access to vaccine and medication for appropriate management of COVID-19 outbreak in the world is a serious and growing emergency problem for the community equivalent for the growing more than millions of developing and developed in the world.

This study review, the research team members concluded the results clearly and briefly related to the key relevant literature to the findings of the 20 selected relevant articles based on selection criteria. Almost all reviewed studies were reported from December 31 2020 to 19 April 2020. Most (55%) of the analysed research articles were from China. This indicated that there were about 44 pneumonia cases with unknown etiology in Wuhan City, Hubei Province of China between 31 December 2019 and 03 January 2020. Meanwhile, after one week of duration, the National Health Commission China reported to the WHO that the epidemic disease outbreak had arisen from contacts in a single seafood market in Wuhan City. However, the Chinese government also confirmed a new COVID-19 epidemic from the infected individual since 07 January 2020 [38].

This section (1) discusses the features of COVID-19; SARS-CoV-2; (2) describes magnitude of public health importance and controlling mechanisms of this disease; (3) rising potential effects of a response to health emergencies, prevention and control methods of COVID-19; (4) describes instruments used to measure causes of COVID-19; (5) identify the level of risk prevention and control methods of COVID-19; furthermore, (6) the result of prevention and control mechanisms of COVID-19.

The scholars identified 20 studies, the majority of 6 (30%) indicated the vulnerability of patients and health professionals with COVID-19 and investigated the clinical outcome for patients. Similarly, a study conducted in Italy [34] suggested that the newly pandemic diseases outbreak, COVID-19 has threatened the health status of the communities, transportation systems, and trading and business activities including overall commerce in world countries including Italy. Moreover, the epidemiologic and demographic characteristics of previous SARS-CoV-01, MERS-CoV viruses, and experience of an emergency physician in the country’s were supported to identify the causes and complications of COVID-19 in order to address the issues of COVID-19 [34]. Nonetheless, the reviewed studies showed that most of the world countries have a lack of testing kits for the diagnostic evaluation of COVID-19 and skilled professionals related to new cases of COVID-19. As a result, most of those who died in the community died due to a lack of early diagnosis of their cases and due to the difficulty of differentiating the pathological characteristics of the virus and possibly increased the mortality rate of the population in world nations. Similarly, a study conducted in Fujian, China [35] found that the pathological features of COVID-19 have a great similarity with SARS due to observing symptoms of acute respiratory diseases syndromes; but the latest pathological examination of COVID-19 exposed the clear mucinous secretions in the lungs. Therefore, early recognition of COVID-19 by health professionals and all expertise is still required.

This research showed that the majority of reviewed studies were focused on the importance of emergency response such as quarantine, isolation, the distance between persons and other prevention and control methods for COVID-19 in various countries as well as key information about the meaning of COVID-19, method of transmission, causes and epidemiologic characteristics, management and ways to prevent and control it. However, there is an increasing number of confirmed cases and deaths in both developing and developed countries. In particular, there is increasing socioeconomic crisis and social interaction. This is supported by a recent WHO report of 29 February 2020, which found that the application of travel, and import and export system such as trade restrictions to countries experiencing a COVID-19 outbreak has begun to be implemented. However, it has had significant social and economic effects, and has affected productivity, the resource used for intervention, and all other growth and development stages of every country in the world [37, 38].

Similarly, the study conducted in China by [37] agreed that the implementation of a Public Health Emergency of International Concern which was declared by the World Health Organization since the first cases of COVID-19 outbreak happened in China. The implementation of prevention and control strategies like wearing masks, washing hands using soap or sanitizers for effective hand hygiene care practices, spacing the contact between individuals in order to avoid public contact, early diagnosis and overall case detection, contact tracing, and quarantines were the most effective way to reduce COVID-19 transmission [37]. This review indicated that the implications for the importance of improving the work environment to increase awareness of healthcare providers and all communities on the way how to slow COVID-19.

The review revealed several carefully developed instruments and analytic approaches for measuring the level of risk, effects response to potential health emergencies, prevention, and control methods COVID-19. While these measures were developed for a specific study, a brief report and laboratory investigation official cases to identified confirmed diagnosis of COVID-19; SARS-CoV-2 outbreak and to address the research questions, which accounted for 6 (30%) of the level of risk, the effects a response to potential health emergencies, prevention, and control method of COVID-19 outbreak measurements, was the most used strategy.

The reviewed study also showed that there was a lack of attention to COVID-19 and it was very limited in some of the vulnerable countries and other territories. Therefore, 6 studies identified confirmed diagnosis of COVID-19; the SARS-CoV-2 outbreak. In this regard, there was a decline in the maximum number of new cases confirmed in China and it is relatively low in some cities in the country. It indicated that the lesson learned could help to control the outbreak of diseases in other countries. Moreover, all tested results from 35 specimens were negative. This instrument can provide a useful stepping stone for the further study of slow COVID-19 [39].

In some studies, measures were taken as part of an instrument; however, it is important to use them as measures to identify the level and risk response to emergency public health and prevention and control method of COVID-19 outbreak and to better understanding in health professionals and communities as to how to prevent and control COVID-19 transmission. Furthermore, it is also helpful to investigate the method of response to emerging public health for COVID-19. In the same way as this review, a WHO draft report (3 February 2020) suggested that an instrument such as strategic preparedness and response plan was used to stop further transmission of COVID-19 within China and that this was a critical and important instrument for other countries to mitigate the common impact of COVID-19 outbreak in all countries [38, 39].

The majority of these reviewed studies utilized brief reports and laboratory investigations with including official confirmed COVID-19 case approaches to answer the research questions. Meanwhile, a few studies used an online survey, a summary of experience, and longitudinal cohort method which helps to collect, analyze and interpret data. They used this method to assess the phenomenon, process, perspective, and views of healthcare providers and communities as well as governments, policymakers, and other stakeholders. Half of the reviewed studies, however, used various methods to address the research question as such situational analysis, clinical assessment and epidemiological survey, descriptive cross-sectional study, and an interventional plat for PPE task forces, simulation, and model approaches. A quality score based on respondents’ opinions within the reviewed studies using a standard form was used to obtain information according to the study design. The majority of reviewed studies frequently used situational and response-based analysis, descriptive and logistic regression, and follow up accompanied by use channels to compute study variables and socioeconomic characteristics including the final result of their studies [38, 39].

The findings of this review showed that older age groups and most of the vulnerable groups were the new migrants and journey-related case groups as well as people who are suspected and prone with COVID-19 and related to pandemic disease outbreaks. Similarly, the study was conducted in European countries, the COVID-19 related risk infection for people is higher in older adults in the EU/EEA and UK [40].

The results of this review study showed that the capacity to prevent, investigate, and control the COVID-19 outbreak is different from country to country. This indicated that there are a wide variety of methods to slow COVID transmission. Similarly, a study conducted in the UK [41] found that traditional public health prevention and control methods are effective to reduce the maximum number of disease outbreaks, morbidity and mortality rate globally if the countries have an opportunity to implement appropriately but not fully contain the outbreak of COVID-19. It is supported by [42] quarantine, especially complete social distancing has been implemented to slow down the spread of the Coronavirus outbreak (COVID-19) in the USA and many other European countries including Italy [41, 42].

The finding also revealed that most of the confirmed cases and patients infected with COVID-19 infection pandemic diseases outbreak and having severe symptoms had lower lymphocyte counts and higher plasma levels and other laboratory test results. Similarly, a study conducted in the USA [43] suggested that the impact of the pandemic COVID-19 outbreak on clinical microbiology laboratories was very high. Therefore, the rapid and accurate diagnosis and monitoring of SARS-CoV-2 infections and greatly assist in the control of this disease outbreak has been implemented using a combined device existing at the point of care with accessible measurements [43].

The review study suggested that in the first week of the COVID-19 outbreak occurred in China, the majority of the healthcare providers were administered blood transfusion as emergency care and there was a significant changed via the result of a safe life. Similarly, the WHO has adopted the Guidance for National Blood Services on Protecting the Blood Supply During Infectious Disease Outbreaks [44, 45] and risk assessment publications on pandemic COVID-19 outbreak from continental, regional networks and any higher institutions and health sectors [46, 47, 48].

6.Conclusion

Even though the novel COVID-19 outbreak on 31 December 2019 in Wuhan, Hubei city, China, and countries worldwide, there are normally relevant studies to determine the risk and impact of response to a public health emergency, prevention, and control methods of COVID-19 to slow transmission in countries. The finding showed that there has been an unprecedentedly rapid spread of pandemic COVID-19 outbreak across 212 countries with more than 1.1. million confirmed cases and more than 100,000 deaths worldwide as of 20 April 2020. Therefore, each country’s government should be drawn alongside to prevent and control of pandemic COVID-19 outbreak. Moreover, worldwide public health emergency responses with valuable support from the community, health professionals and governments will need to be discussed to find the way to slow COVID-19 transmission and other related action to pandemic diseases.

The WHO declared the COVID-19 outbreak to constitute a public health emergency of international concern since 30 January 2020. The nature of the COVID-19 outbreak was changed to pandemic level due to increased transmission, magnitude, severity, morbidity, and mortality rate across the world. Therefore, all governments should create strong partners and collaborate with joint activities using global outbreak prevention and control policy to respond to the COVID-19 emergency and decrease numbers of cases and deaths around the world.

As of today, there are still no any existing and available medicine for the treatment of the COVID-19; SARS-CoV-2 outbreak and still a lack of the effective potential therapeutic agents for other disease outbreaks as such Ebola, SARS-01 and MERS Coronavirus-caused respiratory problems, however, they have a little evidence to manage the symptoms related to previous viral endemic and pandemic disease outbreaks. Hence, there is increasing a probability of COVID-19 transmission among the world communities and the impact of the diseases in world nations.

The reviewed study finding revealed that almost all continents have no pre-existing immunity in the population against the new COVID-19 and anybody in the communities may be vulnerable to this disease outbreak. This is an issue for world communities and has the potential to kill all populations; therefore, international, national, regional, and local donors should have an important role to play in mitigating the economic impacts of the COVID-19 outbreak. Moreover, a combination of strong national governance, strict rules and regulations, strong healthcare providers and community awareness and citizen involvement, and wise use of big COVID-19 row data and digital technologies are very important to form the basic foundation of mitigation and curative measures of a disease outbreak. The implications of this review study are significant in certain areas of the COVID-19 outbreak which are worthy of further research.

The research team concluded that future research must look at the risk and impacts of a various public health emergency, prevention, and control methods of COVID-19 outbreak and other epidemic and pandemic diseases around the world. Moreover, these must be with respect to incubation periods, how drugs are synthesized, vaccine sources and effectiveness and frequency, the effect of a public health emergency, the impact of COVID-19 on each country’s economic, social and environmental growth and development including overall crisis, community health status, and personal and professional skill development to slow COVID-19 transmissions.

Therefore, the optimal duration and frequency of this response to a public health emergency to prevent and control of COVID-19 and to create positive impacts can be verified. In addition, it is valuable to investigate which types of responses to public health emergencies will prevent and control the COVID-19 outbreak effects and which are more targeted. As a result, hand washing with sanitizers, the distance between individuals, call for health professionals, quarantine, isolation, and overall precautionary measures and critical awareness of healthcare providers and communities to slow COVID-19 transmission can be designed accurately and effectively.

The effect of quarantine, especially home quarantine, school closure, and another early warnings as a public health emergency to prevent and control of COVID-19 pandemic outbreak transmission was regarded as a positive outcome, but it needs to be implemented with precaution. Therefore, we recommended that the use of various measurements of slow COVID-19 pandemic disease outbreak for comparison of outcomes in future researches.

Abbreviations

Authors’ contributions

AAG designed the review protocol. Both AAG and TB designed the search strategy for this systematic review protocol and performed the search in collaboration with online healthcare librarians. AAG, TB, EW, AFA,SM, HZA, AK, BAT, BAA, BSD, NSZ,AGG, BM, and QKY have participated in data selection, data extraction, data analysis, and interpretation of the results. All authors critically revised, read, and approved the final manuscript.