Affiliations: [a] Biological Sciences Department, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia | [b] Main Medical Laboratory, Medical Services, Saudi Airlines, Jeddah 21231, Saudi Arabia | [c] Therapeutic and Protective Proteins Laboratory, Protein Research Department, Genetic Engineering and Biotechnology Research Institute, City for Scientific Research and Technology Applications, New Borg EL-Arab 21934, Egypt
Correspondence:
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Corresponding author: E.M. Redwan, Biological Sciences Department, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia. Main Medical Laboratory, Medical Services, Saudi Airlines, P.O. Box 167, Cost Center 507, Jeddah 21231, Saudi Arabia. E-mail: [email protected], [email protected].
Abstract: Our previous results showed higher level of anti-Hib IgG (2.41 μg/ml) average geometric mean concentration (GMC) regardless of age and gender, followed by levels of IgM (0.91 μg/ml) and IgA (0.34 μg/ml), reflecting the prevalence of immunity against Hib. Current study was evaluated the avidity profile for these high anti-Hib concentration. The IgM avidity analysis did not revealed any significant results between male and female values. While, the average of IgA avidity in male samples were significantly (P< 0.05) higher than the average of female. Also, The result showed that high percentage of population has moderate to high IgG avidity. The study showed lower avidity percentages of both IgM and IgA comparing to IgG. More studies are suggested to be done on individuals with low avidity considering the secondary immunodeficiency in participant’s history.
Keywords: Haemophilus influenzae type b (Hib), anti-polyribosyl-ribitol phosphate (PRP), conjugate vaccine, prevalence, antibodies avidity
