Affiliations: Equipe de Bioinformatique Génomique et Moléculaire
(EBGM), INSERM E03-46, Université Denis Diderot - Paris 7, case 7113, 2,
place Jussieu, 75251 Paris, France. Tel.: +33 1 44 27 77 31; Fax: +33 1 43 26
38 30 | Université Pierre & Marie Curie - Paris 6,
75005 Paris, France | CEA, 17 avenue des Martyrs, 38054 Grenoble, France.
E-mail: [email protected]
Note: [] Corresponding author
Abstract: A statistical analysis of the PDB structures has led us to define a
new set of small 3D structural prototypes called Protein Blocks (PBs). This
structural alphabet includes 16 PBs, each one is defined by the (Φ,
Ψ) dihedral angles of 5 consecutive residues. The amino acid
distributions observed in sequence windows encompassing these PBs are used to
predict by a Bayesian approach the local 3D structure of proteins from the sole
knowledge of their sequences. LocPred is a software which allows the users to
submit a protein sequence and performs a prediction in terms of PBs. The
prediction results are given both textually and graphically.
