Two Genetic Algorithms for Identification of Regulatory Signals

Issue title: 3rd International Conference on Bioinformatics of Genome Regulation and Structure (BGRS 2002), June 2002, Novosibirsk, Russia

Article type: Research Article

Authors: Stavrovskaya, Elena D. | Mironov, Andrey A.^;

Affiliations: Integrated Genomics, POBox 348, Moscow, 117333, Russia | State Scientific Center GosNIIGenetika Moscow 113545, Russia

Abstract: There exist numerous algorithms for identification of regulatory signals in unaligned DNA fragments. Here we present two genetic algorithms for signal identification and describe their implementation and testing on simulated and real data. The first algorithm selects the start position of the signal in a given fragment. The second one builds a "universal" word that is recognized by the transcription factor. We compare these approaches and study the behavior of the genetic algorithm.

Keywords: regulation signal, genetic algorithms

Journal: In Silico Biology, vol. 3, no. 1-2, pp. 49-56, 2003