GeneNet Database: Description and Modeling of Gene Networks

Article type: Research Article

Authors: Kolchanov, Nikolay A. | Nedosekina, Eugenia A. | Ananko, Elena A. | Likhoshvai, Vitaly A. | Podkolodny, Nikolay L. | Ratushny, Alexander V. | Stepanenko, Irina L. | Podkolodnaya, Olga A. | Ignatieva, Elena V. | Matushkin, Yury G.

Affiliations: Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia

Abstract: Almost all cellular processes in an organism are controlled by gene networks. Here we report on the analysis of gene networks functioning using two associated methods - data accumulation in GeneNet system and generalized chemical kinetic method for mathematical simulation of gene network functional dynamics. The technology of the usage of these methods is shown on the example of the gene network of macrophage activation.

Keywords: gene network, modeling, mathematical simulation, database designing, macrophage

Journal: In Silico Biology , vol. 2, no. 2, pp. 97-110, 2002