Abstract: Aiming at the problem that the current algorithm of lighting effect cannot achieve a good effect in 3D interior design, this paper proposes an algorithm based on multi algorithm fusion to realize lighting effect in 3D interior design. The algorithm first optimizes the intersection of patch, sphere and rectangle based on ray tracing algorithm, and then optimizes the optimization algorithm and the algorithm of lighting shadow at the same time, it is applied to the realization of lighting effect of 3D interior design. The simulation results show that the algorithm based on multi algorithm fusion is more ideal for the…realization of 3D interior design lighting effect than the existing algorithm.
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Abstract: OBJECTIVE: Osteosarcoma is the most common malignant tumor of bone with high recurrent rate. miR-486 was downregulated and acted as a tumor suppressor in plenty of tumors. The purpose of this study was to explore how miR-486 worked in osteosarcoma on cell invasion and EMT. RESULTS: miR-486 was low expressed in osteosarcoma while PIM1 was overexpressed, and it had negative correlation between miR-486 and PIM1. miR-486 upregulation or PIM1 downregulation could inhibit osteosarcoma cell invasion and EMT. Meanwhile, miR-486 mediated PIM1 expression through binding to PIM1 mRNA 3’-UTR. PIM1 could reveal partial function of miR-486 on osteosarcoma invasion. In addition,…miR-486 low expression or PIM1 overexpression predicted poor prognosis of osteosarcoma patients. CONCLUSION: miR-486 regulated osteosarcoma cell invasion and EMT through targeting to PIM1. miR-486 low expression or PIM1 overexpression predicted poor prognosis of osteosarcoma patients. The newly identified miR-486/PIM1 axis provides novel insight into the pathogenesis of osteosarcoma.
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