Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Purchase individual online access for 1 year to this journal.
Price: EUR 230.00Impact Factor 2024: 1.9
This interdisciplinary journal publishes papers relating the plasticity and response of the nervous system to accidental or experimental injuries and their interventions, transplantation, neurodegenerative disorders and experimental strategies to improve regeneration or functional recovery and rehabilitation.
Experimental and clinical research papers adopting fresh conceptual approaches are encouraged. The overriding criteria for publication are novelty, significant experimental or clinical relevance and interest to a multidisciplinary audience.
Authors: Finger, Stanley
Article Type: Research Article
DOI: 10.3233/RNN-1990-1601
Citation: Restorative Neurology and Neuroscience, vol. 1, no. 6, pp. 367-368, 1990
Authors: Woerly, Stéphane | Marchand, Raymond
Article Type: Research Article
Abstract: The extracellular matrices of living tissue provide scaffolding supports for cell migration and interaction during tissue remodelling and regeneration and therefore may also be relevant to processes of regeneration in the injured central nervous system. We implanted in artificially made cavities of the neostriatum or cortex of adult rats a fluid collagen gelling system into which fetal grafts from either the substantia nigra or cortex were introduced. The collagen polymerizes to form a fibrillar matrix (organogel) which restitutes a physical continuity to the neural tissue. The host tissue reaction consisted of the ingrowth of blood vessels, the migration of mesenchymatous …cells, of reactive astrocytes and of microglia within the bioimplant which became the substrate of heterogeneous cell interactions. As a result, newly formed collagen and carbohydrate-rich materials were deposited upon the collagen matrix while the bioimplant underwent remodelling. After 2 months, the original matrix was replaced by a glial–mesenchymal matrix into which nerve fibers of the lesioned striatum regenerated. The neural transplants survived and differentiated according to the stability of collagen matrices. We conclude that a collagen gelling system can be used to introduce a scaffolding structure into open brain wounds, and suggest that instead of sealing off the lesion, the ensuing scarring process rather favors tissue repair by establishing a glial-mesenchymal matrix well-suited for inducing intrinsic and extrinsic (grafts) neural regeneration. Show more
Keywords: Brain lesioning, Collagen matrix, Neural graft, Transplantation, Regeneration, Scar remodelling, Picrosirius, Tissue interactions
DOI: 10.3233/RNN-1990-1602
Citation: Restorative Neurology and Neuroscience, vol. 1, no. 6, pp. 369-385, 1990
Authors: Finklestein, Seth P. | Fanning, Paul J. | Caday, Cornelio G. | Powell, Penelope P. | Foster, Jonathan | Clifford, Ellen M. | Klagsbrun, Michael
Article Type: Research Article
Abstract: Focal injury to the mammalian central nervous system (CNS) results in a cascade of cellular responses – including glial and capillary proliferation and neural sprouting – that contribute to the repair of neural tissue and to the recovery of neurological function. Fibroblast growth factors (FGFs) are heparin-binding polypeptides with potent trophic effects on CNS glia, endothelia, and neurons; both acidic and basic forms are found in the mammalian CNS. We used heparin-affinity chromatography coupled to Balb/c 3T3 mitogenic assay to show a marked increase in levels of bioactive FGFs in tissue surrounding focal cortical lesions of the mature rat brain …at one week after injury. Heparin-affinity HPLC showed that this increase was due to a large increase in levels of basic FGF (bFGF), and a much smaller increase in levels of acidic FGF (aFGF) after injury. Increased bFGF bioactivity was paralleled by increased levels of immunoreactive bFGF, as assessed by Western blotting techniques. Increased bFGF levels may play an important role in the cascade of cellular reactions occurring after focal brain injury. Show more
Keywords: Fibroblast growth factors, Brain injury
DOI: 10.3233/RNN-1990-1603
Citation: Restorative Neurology and Neuroscience, vol. 1, no. 6, pp. 387-394, 1990
Authors: Pereda, A. | Macadar, O. | Trabal, I. | Cibils, D. | Echagüe, J.V. | Budelli, R.
Article Type: Research Article
Abstract: Static and dynamic measurements of the righting reflex were performed in intact toads (Bufo arenarum platensis) and at different stages of recovery from hemilabyrinthectomy. Reflex activity was evaluated by the toad's capacity to maintain a horizontal head position while rolled sideways. Static data were obtained from frontal photographs. In dynamic experiments platform position (stimulus) was measured through a potentiometer, while a linear accelerometer glued to the cranium was used to record head tilts. The dynamic study included a linear systems analysis using sinusoids of 0.5–3 Hz with rolls of up to 30° to each side. Hemilabyrinthectomy produced a head tilt …towards the lesioned side, and gain decay and phase lag increase in the dynamic response. All postural defects recovered progressively within 30–60 days as already described in other species. Nevertheless, the tonic head deviation produced by dynamic stimuli of frequencies above 1 Hz did not recover. This remnant defect has not been observed in previous studies in which only static observations were performed. The involvement of a frequency-dependent rectifying mechanism in postural compensation is discussed. Show more
Keywords: Vestibular, Righting reflex, Dynamic response, Hemilabyrinthectomy, Restoration, Plasticity
DOI: 10.3233/RNN-1990-1604
Citation: Restorative Neurology and Neuroscience, vol. 1, no. 6, pp. 395-402, 1990
Authors: Kertesz, Andrew
Article Type: Book Review
DOI: 10.3233/RNN-1990-1605
Citation: Restorative Neurology and Neuroscience, vol. 1, no. 6, pp. 403-404, 1990
Article Type: Research Article
DOI: 10.3233/RNN-1990-1606
Citation: Restorative Neurology and Neuroscience, vol. 1, no. 6, pp. 405-411, 1990
Article Type: Other
DOI: 10.3233/RNN-1990-1607
Citation: Restorative Neurology and Neuroscience, vol. 1, no. 6, pp. 413-416, 1990
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
[email protected]
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office [email protected]
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
如果您在出版方面需要帮助或有任何建, 件至: [email protected]