Affiliations: [a] Department of Occupational Health Engineering, School of Public Health, Yazd University of Medical Sciences, Yazd, Iran
| [b] Department of Toxicology and Pharmacology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran
| [c] Department of Ergonomics, School of Health, Hamadan University of Medical Sciences, Hamadan, Iran
Correspondence:
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Address for Correspondence: Rashid Heidari Moghadam, Assistance Professor, Hamadan University of Medical Sciences, Hamadan, Post code: 65178 Hamadan, Iran. Tel.: +9838380025; Fax: +9838380509; E-mail: [email protected].
Abstract: BACKGROUND: Exposure to compounds used in ceramic industries appears to be associated with induction of oxidative toxic stress. Objective: This cross sectional study was undertaken to assess the oxidative toxic stress parameters associated with occupational exposure to ceramic dust. METHODS: Forty ceramic-exposed workers from a ceramic manufacturing industry and 40 unexposed referent subjects were studied. A questionnaire containing information regarding demographic variables, occupational history, history of any chronic disease, antioxidant consumption, and use of therapeutic drugs was administrated to them. Oxidative toxic stress biomarkers including lipid peroxidation (LPO), total antioxidant power (TAP), levels of total Thiol groups (TTG) and catalase (CAT) activity were measured. RESULTS: Significant increments in blood LPO levels, CAT activity and concomitant lower TAP were observed in ceramic exposed workers in comparison to referent group. No statistically significant difference was noted between the means of TTG levels between the groups. CONCLUSIONS: Findings of the study indicate that occupational exposure to ceramic dust induces oxidative toxic stress. Supplementation of workers with antioxidants may have beneficial effects on oxidative damages in ceramic industries.
Keywords: Workers, total antioxidant power, oxidative stress
