Affiliations: Department of Chemistry, University of Engineering and Technology, Lahore, Pakistan | Department of Microbiology and Molecular Genetics, Punjab University, Lahore, Pakistan | Department of Chemistry, King Fahd University of Petroleum and Minerals, Dhahran, Saudi Arabia
Note: [] Corresponding authors: A.A. Isab, Department of Chemistry, King Fahd University of Petroleum and Minerals, Dhahran 31261, Saudi Arabia. E-mail: [email protected]; S. Ahmad, Department of Chemistry, University of Engineering and Technology, Lahore 54890, Pakistan. E-mail: [email protected].
Abstract: Silver(I) complexes of 2-mercaptopyridine (Mpy), [Ag(Mpy)]NO3 and [Ag(Mpy)2]NO3, and the first mixed-ligand complex having a thione and thiolate coordinated to Ag(I), [Mpy–Ag–Tm] (Tm=thiomalate) have been prepared and characterized by IR and NMR spectroscopy. The 1H and 13C NMR spectra show the presence of both ligands in the mixed-ligand complex, [Mpy–Ag–Tm]. An upfield shift is observed in the >C=S resonance of Mpy and C=O resonances of thiomalate in 13C NMR, while the other resonances are shifted downfield. The complexes showed relatively high antibacterial activity (inhibition zone of 6–11 mm) against a gram +ve bacterium, Bacillus subtilis, as compared to that (inhibition zone of 4 mm) against a gram −ve bacterium, Escherichia coli.
