LC/MS/MS warfarin assay – An emerging tool for the early detection of cytochrome P450‐associated drug–drug interactions in drug discovery

Issue title: First International Conference on Biomedical Spectroscopy: From molecules to men, Cardiff, UK, 7–10 July 2002, Part II

Article type: Research Article

Authors: Zhang, Zhi‐Yi

Affiliations: Drug Safety and Disposition, Eisai Research Institute, 100 Research Drive, Wilmington, MA 01887, USA Tel.: +1 978 661 7242; Fax: +1 978 657 7715; E‐mail: zhi‐[email protected]

Abstract: The LC/MS/MS warfarin assay, combining stereo‐ and regioselective cytochrome P450 (CYP) form‐specific warfarin hydroxylation with sensitive and specific LC/MS/MS detection technique, is emerging to be a promising tool for the study of CYP‐associated drug–drug interactions for new chemical entities (NCEs) during drug discovery process.

Journal: Spectroscopy, vol. 17, no. 2-3, pp. 491-502, 2003