Training with optic flow stimuli promotes recovery in cortical blindness

Article type: Research Article

Authors: Awada, Asmara^{a; *} | Bakhtiari, Shahab^b | Legault, Catherine^{c; d} | Odier, Celine^e | Pack, Christopher C.^a

Affiliations: [a] Department of Neurology and Neurosurgery, McGill University, Montreal, Canada | [b] Department of Computer Science, McGill University, Montreal, Canada | [c] McGill University Health Center (MUHC), Montreal, Canada | [d] Montreal Neurological Institute and Hospital, Montreal, Canada | [e] Neurovascular Health Program, Department of Medicine (Neurology), Centre Hospitalier de l’Universite de Montreal, Montreal, Canada

Correspondence: [*] Corresponding author: Asmara Awada 3801, University Street, H3A 2B4, Montreal, Quebec, Canada. E-mail: [email protected].

Abstract: Background:Cortical blindness is a form of severe vision loss that is caused by damage to the primary visual cortex (V1) or its afferents. This condition has devastating effects on quality of life and independence. While there are few treatments currently available, accumulating evidence shows that certain visual functions can be restored with appropriate perceptual training: Stimulus sensitivity can be increased within portions of the blind visual field. However, this increased sensitivity often remains highly specific to the trained stimulus, limiting the overall improvement in visual function. Objective:Recent advances in the field of perceptual learning show that such specificity can be overcome with training paradigms that leverage the properties of higher-level visual cortical structures, which have greater capacity to generalize across stimulus positions and features. This targeting can be accomplished by using more complex training stimuli that elicit robust responses in these visual structures. Methods:We trained cortically blind subjects with a complex optic flow motion stimulus that was presented in a location of their blind field. Participants were instructed to train with the stimulus at home for approximately 30 minutes per day. Once performance plateaued, the stimulus was moved deeper into the blind field. A battery of pre- and post-training measures, with careful eye tracking, was performed to quantify the improvements. Results:We show that 1) optic flow motion discrimination can be relearned in cortically blind fields; 2) training with an optic flow stimulus can lead to improvements that transfer to different tasks and untrained locations; and 3) such training leads to a significant expansion of the visual field. The observed expansion of the visual field was present even when eye movements were carefully controlled. Finally, we show that regular training is critical for improved visual function, as sporadic training reduced the benefits of training, even when the total numbers of training sessions were equated. Conclusions:These findings are consistent with the hypothesis that complex training stimuli can improve outcomes in cortical blindness, provided that patients adhere to a regular training regimen. Nevertheless, such interventions remain limited in their ability to restore functional vision.

Keywords: Cortical blindness, vision restoration, training-induced brain plasticity, perceptual learning, motion perception

DOI: 10.3233/RNN-211223

Journal: Restorative Neurology and Neuroscience, vol. 40, no. 1, pp. 1-16, 2022