Electrical stimulation of referred sensation area alleviates phantom limb pain

Article type: Research Article

Authors: Osumi, Michihiro^{a; b; *} | Shimizu, Daisuke^c | Nishi, Yuki^{a; b} | Morioka, Shu^{a; b}

Affiliations: [a] Graduate School of Health Science, Kio University, Nara, Japan | [b] Neurorehabilitation Research Center, Kio University, Nara, Japan | [c] School of Rehabilitation, Hyogo University of Health Sciences, Kobe, Japan

Correspondence: [*] Corresponding author: Michihiro Osumi, Neurorehabilitation Research Center, Kio University, 4-2-2 Umaminaka, Koryo-cho, Kitakatsuragi-gun, Nara 635-0832, Japan. Tel.: +81 745 54 1601; Fax: +81 745 54 1600; E-mail: [email protected].

Abstract: Background:Patients with brachial plexus avulsion (BPA) usually experience phantom sensations and phantom limb pain (PLP) in the deafferented limb. It has been suggested that evoking the sensation of touch in the deafferented limb by stimulating referred sensation areas (RSAs) on the cheek or shoulder might alleviate PLP. However, feasible rehabilitation techniques using this approach have not been reported. Objective:The present study sought to examine the analgesic effects of simple electrical stimulation of RSAs in BPA patients with PLP. Methods:Study 1: Electrical stimulation of RSAs for 60 minutes was conducted for six BPA patients suffering from PLP to examine short-term analgesic effects. Study 2: A single case design experiment was conducted with two BPA patients to investigate whether electrical stimulation of RSAs was more effective for alleviating PLP than control electrical stimulation (electrical stimulation of sites on side opposite to the RSAs), and to elucidate the long-term effects of electrical stimulation of RSAs. Results:Study 1: Electrical stimulation of RSAs evoked phantom touch sensations in the deafferented limb, and significantly alleviated PLP (p < 0.05). Study 2: PLP was alleviated more after electrical stimulation on RSAs compared with control electrical stimulation (p < 0.05). However, the analgesic effects of electrical stimulation on RSAs were observed only in the short term, not in the long term (p > 0.05). Conclusions:Electrical stimulation of RSAs not only evoked phantom touch sensation but also alleviated PLP in the short term. The results indicate that electrical stimulation of RSAs may provide a useful practical rehabilitation technique for PLP. Future studies will be required to clarify the mechanisms underlying immediate PLP alleviation via electrical stimulation of RSAs.

Keywords: Phantom limb pain, electrical stimulation, referred sensation, brachial plexus avulsion

DOI: 10.3233/RNN-201132

Journal: Restorative Neurology and Neuroscience, vol. 39, no. 2, pp. 101-110, 2021