Affiliations: [a]
Department of Neurology, The Second Clinical Medical College of Jinan University, Guangdong, China
| [b]
Department of Neurology, The Shenzhen People’s Hospital, Shenzhen, Guangdong, China
| [c]
Department of Geriatrics, The Second Clinical Medical College of Jinan University, Guangdong, China
Correspondence:
[*]
Corresponding author: Yi Guo, Ward 3 of Neurology Department, Shenzhen People’s Hospital, No. 1017 Dongmenbei Road, Luohu District, Shenzhen City, Guangdong Province, China. Tel.: +8613902978692; E-mail: [email protected].
Abstract: Purpose: To evaluate the effect of using fluoxetine at different time intervals after ischemic stroke on neurological functional prognosis in China. Methods: The patients enrolled were randomly allocated to three groups. Group A received fluoxetine 20 mg/day immediately; group B received fluoxetine 20 mg/day 7 days after enrollment; and group C did not receive fluoxetine. The therapeutic duration of fluoxetine was 90 days and the follow-up period was 180 days. Results: The mean NIHSS score at day 90 was significantly lower in group A than group C (P = 0.005), while at day 180, the mean score in group A was significantly lower than groups B and C (P = 0.035, P = 0.000), respectively. The mean BI score at day 90 was significantly higher in group A than group C (P = 0.001), while at day 180, the mean score in group A was significantly higher than groups B and C (P = 0.036, P = 0.000), respectively. Regression analysis indicated that lower NIHSS score and higher BI score at day 180 were attributed to the early administration of fluoxetine. Conclusions: In patients with ischemic stroke, early administration of fluoxetine may improve the neurological functional prognosis.
Keywords: Fluoxetine, ischemic stroke, neurological functional prognosis, time intervals
