Safety and feasibility of autologous umbilical cord blood
transfusion in 2 toddlers with cerebral palsy and the role of low dose
granulocyte-colony stimulating factor injections
Affiliations: THAI StemLife, 23rd fl., The Offices at Central World,
Patumwan, Bangkok, Thailand | StemLife Bhd., B/7/15, Kwan, Seng, Kuala Lumpur, Malaysia | Monash University Medical School, Johor Bahru,
Malaysia | Vejthani Hospital, Klong-Chan Bangkapi, 10240 Bangkok,
Thailand
Note: [] Corresponding author: Konstantinos I. Papadopoulos, THAI
StemLife, 23rd fl., The Offices at Central World, 999/9 Rama I, Patumwan, 10330
Bangkok, Thailand. Tel.: +66 2 6131515 8; Fax: +66 2 6131519; E-mail:
[email protected]
Abstract: Purpose: Cerebral palsy (CP) with a prevalence of 2.1 per 1,000 live
births generates variable degrees of incurable developmental disability. The
aim of the present report was to provide insight in the safety and feasibility
of autologous umbilical cord blood (UCB) transfusion with low dose Granulocyte
Colony Stimulating Factor (G-CSF) injections in improving the functional
outcome of children with cerebral palsy. Methods: Two toddlers with diagnosed CP were given autologous
umbilical cord blood (UCB) transfusion accompanied by low dose subcutaneous
granulocyte colony stimulating factor (G-CSF) injections. Results: Gross Motor Function Classification System (GMFCS)
improvements were seen in both without any side effects being noted to date.
Conclusion: In this first report, autologous UCB based intervention
in tandem with low dose sc G-CSF administration seems to be feasible and safe
with encouraging functional outcome improvements in children with CP.
