Erythropoietin as a novel neuroprotectant

Article type: Research Article

Authors: Genc, Sermin | Koroglu, Tolga F. | Genc, Kursad

Affiliations: Department of Medical Biology and Genetics, School of Medicine, Dokuz Eylul University, Inciralti, 35340, Izmir, Turkey | Department of Pediatrics, School of Medicine, Dokuz Eylul University, Inciralti, 35340, Izmir, Turkey | Department of Physiology, School of Medicine, Dokuz Eylul University, Inciralti, 35340, Izmir, Turkey

Note: [] Corresponding author. Tel.: +90 232 412 46 04; Fax: +90 232 259 05 41; E-mail: [email protected]

Abstract: Purpose: To provide an overview of the current knowledge on neuroprotective properties of Erythropoietin (Epo), mechanisms by which Epo produces neuroprotection, and signaling pathways regulated by Epo in the nervous system. Methods: The Medline database was searched for articles on the neuroprotective properties of Epo. Experimental and clinical studies were systematically reviewed. Results: In addition to promoting the survival, proliferation, and differentiation of immature erythroid cells, Epo and the Epo receptor (EpoR) have recently been shown to exist and function in the nervous system. The Epo/EpoR system plays a critical role in neurodevelopment and neuroprotection. Epo ameliorates or prevents neuronal injury by neuroprotective, anti-apoptotic, anti-inflammatory, anti-oxidant, angiogenic, neurogenic and neurotrophic effects in cell culture and animal models of neurological diseases. The clinical effectiveness of recombinant human Epo in ischemic stroke in human patients has also been reported recently. Conclusion: Recent studies suggest that Epo is a potential novel neurotherapeutic agent and further clinical studies are warranted.

Keywords: erythropoietin, neuroprotection, neurodegeneration, apoptosis, signaling pathways, neuroinflammation

Journal: Restorative Neurology and Neuroscience, vol. 22, no. 2, pp. 105-119, 2004