The role of visual experience in the cortical topographic map reorganization following retinal lesions

Article type: Research Article

Authors: Chino, Yuzo M.

Affiliations: University of Houston, 4901 Calhoun Rd., Houston. TX 77204-6052, USA

Note: [] Correspondence to: Yuzo M. Chino, University of Houston, 4901 Calhoun Rd., Houston. TX 77204-6052, USA. Tel.: +1 713 743 1955; Fax: +1 713 743 2053; E-mail: [email protected]

Abstract: The mature visual cortex is capable of reorganizing its functional connections in response to retinal injuries. Although this phenomenon is well established, there are a number of unresolved issues. This paper will review some of the more critical aspects of adult plasticity including those based on our most recent findings. Our preliminary data indicate that a large-scale reorganization of cortical maps following retinal injuries may require an increase in synaptic strengths at key cortical sites promoted by long-term, repeated use.

Keywords: Adult plasticity, visual experience, topographic map reorganization, retinal lesions, visual cortex

Journal: Restorative Neurology and Neuroscience, vol. 15, no. 2-3, pp. 165-176, 1999