Affiliations: Department of Orthopaedic Surgery, Tokyo Medical and
Depital University, Tokyo Japan | lnstitute Of Biological Science, Mitsui
Pharmaceuticals, Inc., Tokyo, Japan
Note: [] Correspondenee to: Dr. Soichiro Itoh, M.D., Department of
Orthopaedic Surgery, Tokyo Medical and Dental University, 1-5-45 Yushima,
Bunkyo-ku, Tokyo 113-8519, Japan. Phone: +81-35803-5279, Fax: +81-35803-5274;
E-mail: [email protected]
Abstract: The effects of pyrimidine heterocyclic compounds (MS-818 and MS-430)
on nerve regeneration were evaluated using the cut-and-suture model of the
right sciatic nerve of Wistar rats. After surgery, 1 or 5 mg/kg/day of MS-818
or MS-430 was intraperitoneally administered for 21 days. Control rats received
the same surgery, but were administered saline instead of a drug. Each week
from week 2, evoked muscle action potentials were recorded on the calf muscle
to compare the ratio of latency and amplitude between tbe experimental and
non-treated side. The specimens were taken from the tibial nerve for light
microscopic observation; and the diameter, density and % axon area of
myelinated axons were evaluated. Tbe results of EMG and histology suggest that
administration of MS-818 is more effective than that of MS-430 and that
administration of 5 mg/kg/day has a higher promoting effect than that of 1
mg/kg/day for sprouting and elongation of the severed nerve. These new
neurotrophic pyrimidine compounds may be a group of possible substances
effective in facilitating nerve regeneration.
