Affiliations: Division of Neuropsychology and Behavioral Neurology,
Otto-von-Guericke-University, Magdeburg, Germany | Department of Neurology, Otto-von-Guericke-University,
Magdeburg, Germany | Department of Neurosurgery,
Otto-von-Guericke-University, Magdeburg, Germany
Note: [] Correspondence to: Manfred Herrmann, MD, Ph.D., Division of
Neuropsy-chology and Behavioral Neurology, Otto-von-Guericke University,
Leipziger Straße 44, D - 39120 Magdeburg, Germany; Tel.: +49-391-67-
15001; Fax.: +49-391-67-15216; E-mail: [email protected]. de;
http://www.med.uni-magdeburg.de/fme/znh/kneuro/DON.HTM
Abstract: The present study aimed at the predictive value of early release
patterns of protein S-100B and neuron specific enolase (NSE) in patients with
traumatic brain injury. We investigated 69 patients who were admitted to the
Department of Neurosurgery following traumatic brain injury. Both NSE and
S-100B serum concentrations during the first three days after admission were
highly and significantly correlated with Glasgow Coma and Coma Remission Scale
scores at the respective blood sampling times as well as 2 weeks later. Signs
of intracranial pathology as evaluated by CCT or MRI scans showed no
association with NSE or S-100B release patterns. Our data support the
hypothesis that NSE and protein S-100B are useful and sensitive
neurobiochemical markers for the early clinical outcome of traumatic brain
injury.
Keywords: NSE, protein S-100B, traumatic brain injury, outcome
