Affiliations: [a] Department of Rehabilitation Medicine, Ichan School of Medicine at Mount Sinai, New York, NY, USA | [b] Department of Physical Medicine and Rehabilitation, Indiana University School of Medicine, Indianapolis, IN, USA | [c] Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA | [d] Department of Neurology, Center for Neuroscience and Regenerative Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
Correspondence:
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Address for correspondence: Kristen Dams-O'Connor, PhD, Assistant Professor, Department of Rehabilitation Medicine, Brain Injury Research Center, Ichan School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1240, New York, NY 10029, USA. Tel.: +1 212 241 7587 (Direct); Fax: +1 212 241 0137; E-mail: kristen.dams-o'[email protected]
Abstract: Objective:To characterize the clinical profiles of individuals with dementia who do and do not report a history of TBI. Introduction:Some evidence suggests that a history of traumatic brain injury (TBI) is associated with an increased risk of dementia later in life. The clinical features of dementia associated with TBI have not been well investigated. While there is some evidence that TBI is associated with increased risk of Alzheimer’s disease (AD), there are also indications that dementia associated with TBI has prominent behavioral, affective, and motor symptoms, making it distinct from AD. Methods:The current study involves secondary analysis of baseline data from the National Alzheimer’s Coordinating Center (NACC) Uniform Data Set (UDS). Results:Individuals with dementia who reported a history of TBI had higher fluency and verbal memory scores and later onset of decline, but they are on more medications, had worse cardiovascular and cerebrovascular health, were more likely to have received medical attention for depression, and were more likely to have a gait disorder, falls, and motor slowness. Conclusion:These findings suggest that dementia among individuals with a history of TBI may represent a unique clinical phenotype that is distinct from known dementia subtypes.
Keywords: Dementia, traumatic brain injury (TBI), National Alzheimer's Coordinating Center (NACC)
