Affiliations: University of Indianapolis, Krannert School of Physical Therapy, Interprofessional Health and Aging Studies, Indianapolis, IN, USA
Correspondence:
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Address for correspondence: Stephanie A. Combs-Miller, PT, PhD, NCS, Professor and Director of Research,
University of Indianapolis, Krannert School of Physical Therapy, Interprofessional Health and Aging Studies,
1400 E. Hanna Ave, Indianapolis, IN 46227, USA. Tel.: +1 317 788 3523; Fax: +1 317 788 3542; E-mail: [email protected].
Abstract: BACKGROUND:Exercise may modify disease progression in persons with Parkinson disease (PD). OBJECTIVE:The purpose of this longitudinal cohort study was to determine factors that predict motor, activity, and participation-based outcomes over two years in exercisers with PD. METHODS:A convenience sample with idiopathic PD was included in the analysis [n = 74; mean age 66.7(8.4) years; male 54%; median months post diagnosis 69.0(76.0), median Hoehn and Yahr score 1.0(2.0)]. Exercise behaviors (minutes of exercise/week, peak rate of perceived exertion (RPE) and mode of exercise) and outcomes of impairment [grip strength], activity [10-meter walk test, functional reach test, activity specific balance confidence scale] and participation [Parkinson Disease Questionnaire-39] were assessed at baseline, 6, 12, 18 and 24 months. RESULTS:Using generalized estimating equations at least one exercise behavior was a significant predictor across most of the models (p≤0.026), with higher RPE predicting better outcomes in all activity and participation domains. Younger age, male gender and lower disease severity also significantly predicted better outcomes over time (p≤0.041). CONCLUSIONS:Exercise behaviors contributed to activity and participation-based outcomes over two years in exercisers with PD. Participation in high-intensity exercise programs may enhance maintenance of health and function over time in individuals with PD.
