Neurochemical Alterations after Brain Injury¹

Issue title: Neuropharmacology

Subtitle: Clinical Implications for Pharmacologic Rehabilitation

Article type: Research Article

Authors: Boyeson, Michael G.

Affiliations: University of Wisconsin-Madison Medical School, Madison, Wisconsin

Note: [1] Some of the work reported in this article was supported by Grant NS23003 from the National Institutes of Health.

Abstract: This article reviews the relationships between alterations in several neurotransmitter systems and functional recovery of sensory and motor functions after trauma to the central nervous system in animal models. The timing of administration of promising therapeutic agents is discussed in relationship to the role of rehabilitation while the subject is under the influence of these agents. If caution is not employed in administering some drugs after injury, deleterious effects on recovery can be observed. Finally, attention is given to the mechanisms of drug-induced recovery and speculation concerning possible links to protein kinases and accessing of learned behaviors that are transiently depressed after brain injury.

DOI: 10.3233/NRE-1991-1107

Journal: NeuroRehabilitation, vol. 1, no. 1, pp. 33-43, 1991