Pharmacological intervention for cognitive deficits and aggression in frontal lobe injury

Article type: Research Article

Authors: Sugden, Steven G. | Kile, Shawn J. | Farrimond, Derald D. | Hilty, Donald M. | Bourgeois, James A.^{; *}

Affiliations: Department of Psychiatry and Behavioral Sciences, University of California, Davis, Sacramento, CA 95817, USA

Correspondence: [*] Address for correspondence: James A. Bourgeois, O.D., M.D., Department of Psychiatry and Behavioral Sciences, University of California, Davis, 2230 Stockton Boulevard, Sacramento, CA 95817, USA. E-mail: [email protected]

Abstract: We present a case that promotes early intervention and pharmacological treatment for the neuropsychiatric sequelae (frontal lobe syndrome, including cognitive impairment and aggressive behavior) associated with traumatic brain injury (TBI) and delirium. The patient, who sustained significant systemic complications related to his trauma, was previously diagnosed with alcohol and drug dependence and antisocial personality disorder. These antecedent conditions and prolonged systemic complications likely played a complicating role in his course of recovery.

Keywords: Amantadine, donepezil, valproate, aggression, frontal lobe syndrome, traumatic brain injury

DOI: 10.3233/NRE-2006-21102

Journal: NeuroRehabilitation, vol. 21, no. 1, pp. 3-7, 2006