Pathophysiological mechanisms at the sources of the endolymphatic hydrops, and possible consequences

Issue title: Proceedings of the GDR Vertige 2019 annual meeting devoted to Endolymphatic Hydrops

Article type: Research Article

Authors: Chabbert, Christian^{a; b; *}

Affiliations: [a] Aix Marseille University-CNRS, Laboratory of Cognitive Neurosciences, UMR 7291, Team Pathophysiology and Therapy of Vestibular Disorders, Marseille, France | [b] Research Group on Vestibular Pathophysiology Unity GDR#, France

Correspondence: [*] Corresponding author: Christian Chabbert, UMR 7291 Laboratory of Sensory and Cognitive Neurosciences, 3, Place Victor Hugo, 13331 Marseille Cedex 3, France. E-mail: [email protected].

Abstract: The mechanisms of ion exchanges and water fluxes underlying the endolymphatic hydrops phenomenon, remain indeterminate so far. This review intends to reposition the physical environment of the endolymphatic compartment within the inner ear, as well as to recall the molecular effectors present in the membranous labyrinth and that could be at the source of the hydrops.

Keywords: Hydrops, endolymph, hydrostatic pressure, models, vertigo, dizziness

DOI: 10.3233/VES-200792

Journal: Journal of Vestibular Research, vol. 31, no. 4, pp. 289-295, 2021