Affiliations: [a] Division of Otolaryngology, IRCCS San Raffaele Scientific Institute, Milan, Italy
| [b] Units of Neurology and Neurophysiology, IRCCS San Raffaele Scientific Institute, Milan, Italy
| [c] Genomics of Renal Diseases and Hypertension Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy
| [d] Neuroimaging Research Unit, INSPE, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy; Vita-SaluteSan Raffaele University, Milan, Italy
Correspondence:
[*]
Corresponding author. Roberto Teggi, Division of Otolaryngology, IRCCS San Raffaele Scientific Institute, via
Olgettina 60, 20132 Milan, Italy. Tel.: +39 2 26433522; Fax: +39 2 26433508; E-mail: [email protected].
Abstract: Ménière’s disease (MD) is an inner ear disorder characterized by a burden of symptoms and comorbidities, including migraine. In both disorders, ionic dysregulation may play a role as a predisposing factor. In recent years. aquaporins have been widely investigated, but the results are far from conclusive. We recently studied the genetics of ionic transporters and the hormone endogenous ouabain as predisposing factors for development of MD. In particular, we found two genetic polymorphisms associated with MD: 1) rs3746951, a missense variant (Gly180Ser) in the salt-inducible kinase-1 (SIK1) gene encoding a Na+, K+ ATPase; 2) rs487119, an intronic variant of gene SLC8A1 coding for a Na+, Ca++ exchanger (NCX-1). Ionic concentration in the brain also plays a role in the pathophysiology of migraine. In this brief review we summarize what has been published on MD and migraine.
