Menière’s disease caused by CGRP - A new hypothesis explaining etiology and pathophysiology. Redirecting Menière’s syndrome to Menière’s disease

Issue title: Proceedings of the GDR Vertige 2019 annual meeting devoted to Endolymphatic Hydrops

Article type: Research Article

Authors: Hegemann, Stefan Carl Anton^{a; b; *}

Affiliations: [a] Balance-Clinic, Nueschelerstrasse, Zurich, Switzerland | [b] Zurich University, Faculty of Medicine, Rämistrasse, Zurich, Switzerland

Correspondence: [*] Corresponding author: Stefan Carl Anton Hegemann, E-mail: [email protected].

Abstract: This paper provides a new hypothetical explanation for the etiopathology and pathophysiology of Menière’s Disease (MD), which to date remain unexplained, or incompletely understood. The suggested hypothesis will explain the close connection of MD and Migraine, the coexistence of endolymphatic hydrops (ELH) and Menière attacks and the signs of inflammation detected in the inner ears of MD patients. Although as yet unproven, the explanations provided appear highly plausible and could pave the way for the generation of the first animal model of MD – an invaluable asset for developing new treatment strategies. Furthermore, if proven correct, this hypothesis could redefine and also reset the actual name of Menière’s Syndrome to Menière’s Disease.

DOI: 10.3233/VES-200716

Journal: Journal of Vestibular Research, vol. 31, no. 4, pp. 311-314, 2021