Affiliations: Department of Anatomy and Regenerative Biology, The George Washington University Medical Center, Washington, DC, USA | Department of Anatomy and Regenerative Biology, The George Washington University Medical Center, 2300 I Street NW, Washington, DC, USA
Correspondence:
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Corresponding author: Kenna D. Peusner, PhD, Department of Anatomy and Regenerative Biology, George Washington University Medical Center, 2300 I Street NW, Washington, DC 20037, USA. Tel.: +1 202 994 3489; Fax: +1 202 994 8885; E-mail: [email protected]
Abstract: The principal cells of the chick tangential vestibular nucleus offer a simple neuron model to study signal processing in second-order, vestibular reflex projection neurons. The principal cells represent a relatively uniform population of vestibular nuclei neurons which receive a major input from the primary vestibular fibers and send axons to targets mainly involved in the vestibuloocular reflexes. Here, studies performed on ion channels involved in the emergence and establishment of signal processing in this morphologically-identified subset of vestibular nuclei neurons are reviewed, including the AMPA glutamate receptor subunits GluR1, GluR2, GluR3, and GluR4 and the potassium channel subunits Kv1.1 and Kv1.2.
Keywords: Emergence of spike firing pattern, immunocytochemistry, confocal imaging
