Affiliations: New York Hospital, Cornell Medical Center, 525 East 68th Street, New York, NY 10021, USA
Correspondence:
[*]
Corresponding author. 220 East 69th Street, New York, NY 10021, USA, Tel.: + 1 212 7374020; fax: + 1 212 7721210.
Abstract: Objective:To determine why patients with normal function of the pituitary-thyroid axis, myofascial pain, and other symptoms resembling those of hypothyroidism respond to a slightly supraphysiological dose of levothyroxin administration. Design:Review and analysis of author’s records drawn from a data base of therapeutic trials. Intervention:Oral administration of levothyroxin, 0.2 mg daily for at least 3 months. Main Outcome Measures:Patient interviews and physical examinations by author. Measurement of differences in paired BMR, serum cholesterol, and subjective response after 3 or more months of thyroid hormone administration, using each patient as his or her own control. Summary:Fifty-seven chemically euthyroid adults of both sexes with myofascial pain and hypothyroid-like symptoms were treated with a slightly supraphysiological dose, 0.2 mg, of levothyroxin daily. Cases were selected recently from a database of 367 therapeutic trials performed by the author between 1954 and 1983. All patients had a normal thyroid profile, and a serum TSH measurement before initiating levothyroxin replacement. BMRs and serum cholesterol determinations before and after at least 3 months of thyroid hormone therapy were compared. A graph was constructed in which each point displayed three responses for each patient: change in resting oxygen consumption, following a 12-h fast (BMR); change in serum cholesterol; and symptom response score. Thirteen TSH levels were slightly elevated. Analysis of the graph suggests that almost all patients with: (1) normal function of the pituitary thyroid axis; (2) non-inflammatory myofascial pain refractory to physical medicine and trigger point therapy; and (3) symptoms and signs resembling hypothyroidism, responded to thyroid hormone therapy. The responses suggest correction of a peripheral block to thyroid hormone in patients with normal pituitary thyrotroph function.
