The kinetics of the polymerization of fibrin in some normal and pathological bloods as studied with the thrombelastograph

Article type: Research Article

Authors: Scott Blair, G.W. | Matchett, R.H.

Affiliations: Oxford Haemophilia Centre, Churchill Hospital, Headington, Oxford, England

Abstract: It is shown that neither the oil damping nor the rest pauses in the current recommended use of the thrombelastograph eliminate the measurement of the viscous part of the complex modulus. The former, however, is advantageous in preventing unwanted oscillations but the latter is best eliminated. In addition to earlier published data, we now have some 30 thrombelastograms, about half from normal subjects and half from hospital patients with various diseases. Apart from severe haemophilia, for which the equation cannot be tested, all these are adequately described by means of a simple equation already discussed in earlier papers (slightly modified) and we conclude that the process of coagulation, which probably simply follows the polymerization of fibrin, may be described by the same kinetic equation.

DOI: 10.3233/BIR-1971-7302

Journal: Biorheology, vol. 7, no. 3, pp. 171-176, 1971