You are viewing a javascript disabled version of the site. Please enable Javascript for this site to function properly.
Go to headerGo to navigationGo to searchGo to contentsGo to footer
In content section. Select this link to jump to navigation

15th International Congress of Biorheology and 8th International Conference on Clinical Hemorheology, Seoul, Korea, May 24–28, 2015: Scientific Program

Sunday, May 24th
15:00–18:00Registration
17:00–18:00DDP Tour
18:00–20:00Welcome Reception
Monday, May 25th
8:45–9:15Opening Session
9:15–10:15Plenary Lecture L1
Chwee Teck Lim: Microfluidic platforms for human diseases: From diagnosis to therapy
10:15–11:00Coffee Break
11:00–12:30Symposia S1–S4
S1: MICROFLUIDICS
Chairs: Chwee Teck Lim and Noo Li Jeon
S1-1Engineering perfusable blood vessel network on a chip
Noo Li Jeon
Seoul National University, Republic of Korea
S1-2Novel microfluidic device for sheathless particle focusing and separation using a viscoelastic fluid
Sangho Kim
Department of Biomedical Engineering, National University of Singapore, Singapore
S1-3Advances and critical concerns in the microfluidic isolation of circulating tumor cells
Hyo-Il Jung
Yonsei University, Republic of Korea
S1-4Ex vivo study of malaria parasite infected blood with microfluidics
Eric Lombardini and Bruce Russell
Department of Microbiology, National University of Singapore, Singapore
S2: MULTIPLE ORGAN DAMAGE: A HEMORHEOLOGICAL APPROACH
Chairs: Kalman Toth and Lajos Bogar
S2-1Leukocyte anti-sedimentation rate predicts life-threatening conditions of polytrauma victims earlier than other conventional inflammatory markers
Lajos Bogar, Livia Szelig, Csaba Loibl, Szilard Rendeki, Timea Bocskai and Csaba Csontos
Department of Anesthesiology and Critical Care, University of Pecs, Hungary
S2-2Long-term hemorheological effects of moderate exercise training in ischemic heart disease patients
Barbara Sandor, Miklos Rabai, Andras Toth, Bela Mezey, Kalman Toth and Eszter Szabados
1st Department of Medicine, University of Pecs, Hungary
S2-3Examination of microcirculation and hemorheological variables in high risk cardiovascular diabetic patients
Katalin Biro, Barbara Sandor, Judit Vekasi, David Kovacs, Kinga Totsimon, Andras Toth, Miklos Kovacs, Judit Papp, Katalin Koltai, Kalman Toth and Gabor Kesmarky
1st Department of Medicine, University of Pecs, Hungary
S2-4Relationship between hemorheology and mortality in the intensive care unit
Kinga Totsimon, Katalin Biro, Zsofia Eszter Szabo, Barbara Sandor, Andras Toth, Kalman Toth, Peter Kenyeres and Zsolt Marton
1st Department of Medicine, University of Pecs, Hungary
S3: MECHANOBIOLOGY
Chair: Susumu Kudo
S3-1Role of nonmuscle myosin regulatory light chain phosphorylation in contractile force generation
S. Deguchia, S. Yokoyamaa, T.S. Matsuia, K. Katob, A. Tomohikoa, O. Taikia, M. Kuraganoc and M. Takahashic
aDepartment of Nanopharmacentical Science, Nagoya Institute of Technology, Japan
bDepartment of Imaging Science, Center for Novel Science Initiatives, National Institutes of Natural Sciences, Japan
cDepartment of Chemistry, Hokkaido University, Japan
S3-2Shear induced alterations in microglia phenotypes
S. Ahna, E. Parka, M. Sona, S. Songb, U. Koa, J. Parka and J. Shina,b
aDivision of Mechanical Engineering, School of Mechanical, Aerospace and Systems Engineering, KAIST, Daejeon, Republic of Korea
bGraduate School of Medical Science and Engineering, KAIST, Daejeon, Republic of Korea
S3-3Mechano-sensing of cells via actomyosin contractility
Taeyoon Kim
Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA
S3-4Role of collagen in bone mechanical integrity
Naoki Sasaki
Department of Advanced Transdisciplinary Science, Hokkaido University, Japan
S4: PLATELET ASSAY AND ITS CLINICAL STUDY
Chairs: Byoung Kwon Lee and Chae-Seung Lim
S4-1Comparison of three platelet function tests in predicting hemostatic disorders
Moon sub Byouna, Chae Seung Lima, HongSeok Seoa and Sehyun Shinb
aDepartment of Laboratory Medicine, College of Medicine, Korea University, Seoul, Republic of Korea
bSchool of Mechanical Engineering, Korea University, Seoul, Republic of Korea
S4-2Migration distance and time based platelet function analysis in a microfluidic system
Byoung-Kwon Leea, Minhee Choa, Chaeseung Limb and Sehyun Shinc
aGangnam Severance Hospital, Yonsei University, Republic of Korea
bCollege of Medicine, Korea University, Republic of Korea
cDepartment of Mechanical Engineering, Korea University, Republic of Korea
S4-3Role of hemostatic function test in clinical practice
Young-Hoon Jeong
Gyeongsang National University Hospital and Gyeongsang National University School of Medicine, Republic of Korea
S4-4A new platelet function assay with an in vivo-mimicking microfluidic system
Hoyoon Leea, Gyehyu Kima, Yeonsoo Kima, Chae-Seung Limb and Sehyun Shina,b
aSchool of Mechanical Engineering, Korea University, Seoul, Republic of Korea
bDepartment of Laboratory Medicine, College of Medicine, Korea University, Seoul, Republic of Korea
12:30–14:00Lunch Break
(Group Photo prior to lunch)
12:30–14:00ISB Business Meeting
14:00–15:00Plenary Lecture L2
Narla Mohandas: The red cell membrane: Past, present and future
15:00–15:30Coffee Break
15:30–17:00Symposia S5–S8
S5: RECENT ADVANCES IN RED CELL RHEOLOGY
Chairs: Brian M. Cooke and Gerard B. Nash
S5-1Red blood cell rheology as a critical regulator of leukocyte and platelet adhesion
Gerard B. Nash
Centre for Cardiovascular Sciences, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
S5-2Blood rheology in sickle cell disease
P. Connesa,b, K. Charlotb, A. Mozarb, M. Grauc, R. Hiersob, N. Lemonned, M. Etienne-Juland, Y. Lamarreb, M.D. Hardy-Dessourcesb and M. Romanab
aLaboratoire CRIS EA647, Université Lyon 1, Lyon, France
bUMR Inserm 1134, Université des Antilles et de la Guyane, Pointe-à-Pitre, Guadeloupe (French West Indies)
cInstitute of Cardiovascular Research and Sport Medicine, German Sport University Cologne, Cologne, Germany
dUnité Transversale de la Drépanocytose, Guadeloupe
S5-3Novel parasite protein kinases and their role in alteration of the rheological properties of malaria-infected red blood cells
Brian M. Cooke, Ghizal Siddiqui and Nicholas I. Proellocks
Department of Microbiology, Monash University, Melbourne 3800, Australia
S5-4Accelerated changes to reticulocyte rheology as a result of malaria parasite invasion
Bruce Russell and Rou Zhang
Department of Microbiology, National University of Singapore, Singapore
S6: EMERGING APPROACHES FOR THE STUDY OF BLOOD CELLS AND BLOOD FLOW
Chair: Yong Keun Park
S6-1In vivo and ex vivo measurements of hemodynamic parameters for various real blood flows
Sang Joon Lee
Center for Biofluid and Biomimic Research, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea
S6-2Motion of red blood cells through limiting geometries: Dissipative particle dynamics study
Igor V. Pivkina, Zhangli Pengb and Ming Daoc
aInstitute of Computational Science, Faculty of Informatics, University of Lugano, Switzerland
bDepartment of Aerospace and Mechanical Engineering, University of Notre Dame, USA
cDepartment of Materials Science and Engineering, Massachusetts Institute of Technology, USA
S6-3Chimerism analysis using flow cytometry after haploidentical hematopoietic stem cell transplantation
Seongsoo Jang
Department of Laboratory Medicine, University of Ulsan, College of Medicine and Asian Medical Center, Republic of Korea
S6-43-D quantitative optical profiling of individual red blood cells at various physiological conditions using diffraction phase microtomography
HyunJoo Park, Kyoohyun Kim, SangYoon Lee and YongKeun Park
Department of Physics, KAIST, Republic of Korea
S6-5Use of functional near infrared spectroscopy as an objective measure of brain response to painful stimuli in sickle cell disease
John Sunwooa, Maha Khaleelb, Payal Shahb, Roberta Katob, Patjanaporn Chalachevaa, Wanwara Thuptimdanga, Jon A. Detterichb, Herbert J. Meiselmanb, Jenny Tsaoc, John C. Wooda,b, Lonnie Zeltzerc, Thomas D. Coatesb and Michael C.K. Khooa
aViterbi School of Engineering, University of Southern California, Los Angeles, CA, USA
bKeck School of Medicine, University of Southern California, Los Angeles, CA, USA
cUniversity of California, Los Angeles, USA
S7: BIOMECHANOPHARMACOLOGY: BIOMECHANICS, BIOREHOLOGY AND PHARMACOLOGY
Chairs: Dong Han and Fulong Liao
S7-1Shear stress: A negative regulator for dendritic cells-induced immune response?
R. Donga,b, C. Wua, H. Yanga, J. Longc, X. Xua,b, H. Xuea, Z. Hua, C. Zhangb, W. Yaod and Z. Zenga
aSchool of Biology & Engineering, Guizhou Medical University, Guiyang, Guizhou, China
bDepartment of Cell Biology, Guizhou Medical University, Guiyang, Guizhou Province, China
cAffiliated Cancer Hospital, Guizhou Medical University, Guiyang, Guizhou Province, China
dCenter of Hemorheology, School of Basic Medical Sciences, Health Science Center of Peking University, Beijing, China
S7-2Mechanical environment directs the response of breast cancer cells to Lapatinib
C. Liua, X. Lia, J. Fenga, F. Liaob and D. Hana
aNational Center for Nanoscience and Technology, China
bInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, China
S7-3Sensing rigidity: Integrin internalization and subsequent events
C. Yang, Y. Zu, J. Du, J. Li and Y. Xu
School of Aerospace, Tsinghua University, China
S7-4Biomechanopharmacology: A new biomechanical update in pharmacology
R. Lianga, Y. Youa, J. Caoa, D. Hanb and F. Liaoa
aInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China
bNational Center for Nanoscience and Technology, Beijing, China
S8: MODELING OF CELL DYNAMICS: CYTOSKELETON AND MEMBRANE
Chairs: Ken-Ichi Tsubota and Taiji Adachi
S8-1Vertex dynamics simulations of viscosity-dependent deformation during 3D multicellular morphogenesis
S. Okudaa, Y. Inoueb, M. Eirakuc, T. Adachib and Y. Sasaia
aOrganogenesis and Neurogenesis Team, RIKEN Center for Developmental Biology, Kobe, Japan
bDepartment of Biomechanics, Institute for Frontier Medical Sciences, Kyoto University, Japan
cFour-Dimensional Tissue Analysis Unit, RIKEN Center for Developmental Biology, Kobe, Japan
S8-2An effect of the mechanical properties of red blood cells on oxygen transfer efficiency
X. Gonga,b, Z. Gonga and H. Huangc
aMOE Key Laboratory of Hydrodynamics, Department of Engineering Mechanics, Shanghai Jiao Tong University, Shanghai, 200240, China
bSJTU-CU ICRC, Shanghai Jiao Tong University, Shanghai, China
cDepartment of Mathematics and Statistics, York University, Toronto, ON, Canada
S8-3Computational modeling of cell invasion dynamics into an extracellular matrix fiber network
Min-Cheol Kima, Jordan Whislera, Yaron R. Silberbergc, Roger D. Kamma,b,c and H. Harry Asadaa,c
aDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
bDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
cBioSystem & Micromechanics IRG, Singapore MIT Alliance for Research & Technology, Singapore
S8-4Trafficking across cell membranes: Shape and orientation matter
Sabyasachi Dasguptaa, Thorsten Authb and Gerhard Gompperb
aMechanobiology Institute, National University of Singapore, Singapore
bTheoretical Soft Matter and Biophysics, Institute of Complex Systems, Forschungszentrum Juelich, Germany
17:00–19:00Poster Session 1
Tuesday, May 26th
8:30–9:30Plenary Lecture L3
Thomas D. Coates: Sickle cell anemia, the quintessential red cell rheological disease: Now a neurological condition?
9:30–10:00Coffee Break
10:00–11:30Symposia S9–S12
S9: HEMORHEOLOGICAL TECHNIQUES: WHICH METHOD TO USE
Chairs: Norbert Nemeth and Peter Kenyeres
S9-1Challenges in experimental hemorheology: Methodological adaptation and applicability of methods investigating micro-rheological parameters in various pathophysiological processes
N. Nemeth, F. Kiss and I. Miko
Department of Operative Techniques and Surgical Research, Institute of Surgery, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
S9-2Red blood cell mechanical stability test in basic research and its adaptability in experimental and clinical investigations
Ferenc Kissa, Kornel Miszti-Blasiusb, Eniko Totha, Pinar Ulkerc and Norbert Nemetha
aDepartment of Operative Techniques and Surgical Research, Institute of Surgery, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
bInstitute of Laboratory Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
cDepartment of Physiology, Akdeniz University Faculty of Medicine, Antalya, Turkey
S9-3Pitfalls to avoid during ektacytometry
Peter Kenyeres, Miklos Rabai, Andras Toth and Kalman Toth
1st Department of Medicine, University of Pecs, Hungary
S9-4Viscometer validation studies for routine hemorheological measurements
Andras Toth, David Kovacs, Kinga Totsimon, Katalin Biro, Peter Kenyeres, Gabor Kesmarky and Kalman Toth
1st Department of Medicine, University of Pecs, Hungary
S10: INNER ORGAN MICROCIRCULATION
Chairs: Lukas Prantl and Dirk Clevert
S10-1Dynamic contrast-enhanced computed tomography: A new diagnostic tool to assess renal perfusion after ischemia-reperfusion injury in mice
Andreas Helck, Margarita Braunagel, Mike Notohamiprodjo, Dirk-Andre Clevert, Nina Schupp, Anne Wagner, Maximilan Reiser and Antje Habicht
Großhadern Institute for Clinical Radiology, University München, München, Germany
S10-2Comparison of mobile ultrasound system and high end ultrasound system in detection of endoleaks
H. Zimmermann, A. Helck, R. Reimann, J. Rubentaler, G. Meimarakis, M. Reiser and D.A. Clevert
Großhadern Institute for Clinical Radiology, University München, München, Germany
S10-3Performance of three-dimensional-shear-wave elastography in the diagnostic work-up of the scrotum
J. Marcon, M. Trottmann, M. D’Anastasi, A. Karl, C.G. Stief, M.F. Reiser and D.A. Clevert
Großhadern Institute for Clinical Radiology, University München, München, Germany
S10-4Platelet-rich plasma affects vitality, differentiation and gene expression of adipose-derived stem cells in vitro
L. Prantl, S. Klein and O. Felthaus
Center of Plastic-, Hand- and Reconstructive Surgery, University of Regensburg, Regensburg, Germany
S10-5Combining adipose-derived stem cells and platelet-rich plasma? A novel one-step protocol for clinical use
L. Prantl, S. Klein and O. Felthaus
Center of Plastic-, Hand- and Reconstructive Surgery, University of Regensburg, Regensburg, Germany
S11: THE ROLE OF ENDOTHELIAL CELL RHEOLOGY IN VASCULAR HEALTH, DISEASE AND DRUG DELIVERY
Chairs: Peter J. Butler and Hanjoong Jo
S11-1Mechano-sensitive genes and epigenetics in atherosclerosis: From mechanobiology to nanomedicine
Hanjoong Jo
Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Division of Cardiology, Emory University, Department of Medicine, Emory University, Atlanta, GA, USA
S11-2Athero-prone flow aggravates innate immune response in endothelium
John Y.-J. Shyy
Department of Medicine/Cardiology, University of California, San Diego, La Jolla, CA, USA
S11-3Mechanotargeting of nanoparticles to vascular endothelium
Chanjin Huang, Pouria Fattahi, Hari S. Muddana, Justin Brown, Sulin Zhang and Peter J. Butler
Department of Biomedical Engineering, Penn State University, PA, USA
S11-4Essential role of the p90RSK-SENP2 module in disturbed flow-induced endothelial dysfunction and atherosclerosis
Jun-ichi Abe and Kyung-Sun Heo
Department of Cardiology, University of Texas MD Anderson Cancer Center, TX, USA
S12: COMPUTATIONAL HEMODYNAMICS AND HEMORHEOLOGY
Chairs: Junfeng Zhang and Edgar A. O’Rear
S12-1Transcellular model of nanoparticles across the blood–brain barrier
Lin Zhang, Jie Fan and Bingmei M. Fu
Department of Biomedical Engineering, The City College of The City University of New York, New York, NY, USA
S12-2Eddy analysis for hemolysis in turbulent flows
Edgar A. O’Rear, Mesude Ozturk and Dimitrios V. Papavassiliou
School of Chemical, Biological and Materials Engineering, University of Oklahoma, Norman, OK, USA
S12-3Blood cell flows in the entrance region of microvessels: Cell-free layer development and wall shear stress variation
Othmane Oulaid and Junfeng Zhang
Bharti School of Engineering, Laurentian University, Sudbury, ON, Canada
S12-4Simulations of device-induced thrombosis near an asymmetric sudden expansion
Joshua O. Taylora,b, Richard S. Meyerb, Steven Deutschb and Keefe B. Manninga,c
aDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, PA, USA
bApplied Research Laboratory, The Pennsylvania State University, State College, PA, USA
cDepartment of Surgery, Penn State Hershey Medical Center, Hershey, PA, USA
11:30–12:30Free Communications O1–O3
O1: FLOW VISUALIZATION AND MODELING
Chairs: Sang Joon Lee and Joon Sang Lee
O1-1Model studies on the role of vibration in the development of cerebral aneurysms
Dieter Walter Liepscha, Andrea Balassob and Sergej Frolovc
aMunich University of Applied Sciences, Germany
bTechnical University of Munich, Germany
cTambov University, Russian Federation
O1-2Ex vivo measurement of blood flows using X-ray PIV technique
Hanwook Park, Eunseop Yeom and Sang Joon Lee
Pohang University of Science and Technology (POSTECH), Republic of Korea
O1-3Lattice Boltzmann-immersed boundary approach for vesicle motion and trajectory in bifurcated vessel
Ji Young Moona,b, Young Woo Kima and Joon Sang Leea
aSchool of Mechanical Engineering, Yonsei University, Republic of Korea
bThe University of Sydney, Sydney, Australia
O1-4A comparative study of centrifugal blood pumps
Wonjung Kima, Sung-Gil Kima, Seokbin Honga, Taehong Kima, Sungmin Honga, Minwook Changa, Mohammad Moshfeghia, Seongwon Kanga, Shin-Hyoung Kangb and Nahmkeon Hura
aDepartment of Mechanical Engineering, Sogang University, Republic of Korea
bDepartment of Mechanical and Aerospace Engineering, Seoul National University, Republic of Korea
O2: RED BLOOD CELL MECHANICS
Chair: Sung Yang
O2-1Study on RBC (red blood cell) deformability under various shear rate condition using two plane parallel gold electrodes
Ji-chul Hyun, Taekeon Jung, Hanbyul Kim and Sung Yang
Gwangju Institute of Science and Technology (GIST), Republic of Korea
O2-2Evaluation of sub-hemolytic red blood cell damage based on changes of cell deformability
M. Turkaya, B. Eglenena, G. Yavasa, M.J. Simmondsb, H.J. Meiselmanc and O. Yalcina
aKoc University School of Medicine, Istanbul, Turkey
bHeart Foundation Research Centre, Griffith Health Institute, Griffith University, Queensland, Australia
cDepartment of Physiology and Biophysics, Keck School of Medicine, Los Angeles, CA, USA
O2-3Shear stress induces F-actin remodeling in erythroid cells by regulating E-Tmod isoforms
Weiyun Mua, Lanping Amy Sungb and Weijuan Yaoa
aHemorheology Center, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
bDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, USA
O2-4Variation in red blood cells’ deformability within the whole blood using sinusoidally changing shear flow
Nobuo Watanabe, Tatsuya Tsuzuki and Yusuke Suzuki
Department of Bio-science and Engineering, College of Systems Engineering and Science, Shibaura Institute of Technology, Japan
O3: FLOW AND RED BLOOD CELL INTERACTION IN MICROCHANNELS AND THE MICROCIRCULATION
Chair: Simon Song
O3-1Investigation of the viscoelastic property of flowing erythrocyte suspensions with oscillatory flow rate using a wall-patterned electrode configuration
Byung Jun Kima, Sulaiman Khanb and Sung Yanga,b
aDepartment of Medical System Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju, Republic of Korea
bSchool of Mechatronics, Gwangju Institute of Science and Technology (GIST), Gwangju, Republic of Korea
O3-2S22 is required during the regulation of blood flow for the vascular development in zebrafish
Xiang Xie, Ting Sun, Daoxi Lei, Yongfei Liu, Lu Huang, Tian Zhou, Yi Wang and Guixue Wang
College of Bioengineering, Chongqing University, Chongqing, China
O3-3Hybrid capillary-inserted microchannel for sheathless viscoelastic particle focusing and separation
Jeonghun Nam, Justin Kok Soon Tan and Sangho Kim
Department of Biomedical Engineering, National University of Singapore, Singapore
O3-4Yield stress to assess the risk of microcirculatory impairment in acute coronary syndromes
Euiho Leea, Uiyun Leea,b and Jinmu Jungc,d
aDepartment of Bionanosystem Engineering, Chonbuk National University, Jeonju, Chonbuk, Republic of Korea
bBK 21 Plus Program, Chonbuk National University, Jeonju, Chonbuk, Republic of Korea
cHemorheology Research Institute, Chonbuk National University, Jeonju, Chonbuk, Republic of Korea
dDivision of Mechanical Design Engineering, Chonbuk National University, Jeonju, Chonbuk, Republic of Korea
12:30–14:00Lunch Break
12:30–14:00ISCH Business Meeting
14:00–15:00Hemorheology and Microcirculation Award and Lecture L4
Kalman Toth: The role of hemorheological factors in cardiovascular medicine
15:00–15:30Coffee Break
15:30–17:00Symposia S13–S16
S13: DEPLETION-MEDIATED FORCES IN RBC AGGREGATION AND ADHESION
Chairs: Björn Neu and Herbert J. Meiselman
S13-1RBC aggregation: A tale of two models
Herbert J. Meiselman
Department of Physiology and Biophysics, Keck School of Medicine, Los Angeles, USA
S13-2Macromolecular depletion as a determinant of red blood cell interactions
Björn Neu
Faculty of Life Sciences, University of Applied Sciences Rhine-Waal, Kleve, Germany
S13-3Adhesion strengths, shapes and the dynamics of macromolecule-induced cell clusters at stasis and in microcapillary flow
Christian Wagner
Department of Experimental Physics, Saarland University, Germany
S13-4Signaling mechanisms in regulation of RBC aggregation
Irina Alexandrovna Tikhomirova, Alexei Vasiljevich Muravyov, Elena Petrovna Petrochenko, Anna Olegovna Oslyakova and Yulia Victorovna Malysheva
Yaroslavl State Pedagogical University, Russian Federation
S14: BLOOD FLOW VISUALISATION
Chairs: Masa Takei and Masanori Nakamura
S14-1Visualization of hemolysis at a cellular scale towards the development of a hemolysis simulator based on the deformation analysis of a red blood cell
M. Nakamuraa, K. Okamuraa, K. Umetanib and T. Yagib
aDepartment of Mechanical Engineering, Saitama University, Shimo-Okubo 255, Sakura-ku, Saitama, Japan
bTWINS, Waseda University, Wakamatsu-cho 2-2, Shinjuku-ku, Tokyo, Japan
S14-2Electrical properties of blood and their applicability in thrombosis sensing
A. Sapkotaa, T. Fusea, O. Maruyamab and M. Takeia
aDivision of Artificial Systems Science, Graduate School of Engineering, Chiba University, Japan
bInstitute of Human Science and Biomedical Engineering, National Institute of Advanced Industrial Science and Technology, Japan
S14-3Optical imaging of thrombus formation in mechanical circulatory supports
Daisuke Sakotaa, Tatsuki Fujiwarab, Katsuhiro Ouchic, Tomotaka Murashiged, Ryo Kosakaa, Masahiro Nishidaa and Osamu Maruyamaa
aNational Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan
bDepartment of Cardiovascular Surgery, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan
cDepartment of Advanced Surgical Technology Research and Development, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan
dGraduate School of Science and Technology, Tokyo University of Science, Noda, Chiba, Japan
S14-4Hemodynamics in a pediatric ascending aorta using a pediatric viscoelastic blood model
Bryan C. Gooda, Steven Deutschb and Keefe B. Manninga,c
aDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, PA, USA
bApplied Research Laboratory, The Pennsylvania State University, State College, PA, USA
cDepartment of Surgery, Penn State Hershey Medical Center, Hershey, PA, USA
S15: OSMOTIC GRADIENT EKTACYTOMETRY
Chairs: Max R. Hardeman and Lydie Da Costa
S15-1Ektacytometry: Past and present
Narla Mohandas
New York Blood Center, New York, NY, USA
S15-2Investigations by osmotic gradient ektacytometry in basic and clinical research: Experiences, comparability and information content
N. Nemetha, F. Kissa and K. Miszti-Blasiusb
aDepartment of Operative Techniques and Surgical Research, Institute of Surgery, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
bInstitute of Laboratory Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
S15-3South-east Asian ovalocytosis, no symptoms and total loss of RBC deformability? Further insight in Osmoscan interpretation
M.R. Hardemana, P. McLaughlinb, B.A. van Oirschot-Hermansc, M. Veldthuisd and R. van Wijkc
aDepartment of Transl. Physiol., Acad. Med. Center, University of Amsterdam, The Netherlands
bDepartment of Clin. Chem. and Hematol. Certe-Prim. Care Diagn., Groningen, The Netherlands
cLaboratory of Clin. Chem. and Hematol., University Med. Center, Utrecht, The Netherlands
dRBC Diagnostics, Sanquin, Amsterdam, The Netherlands
S15-4Osmotic deformability curves: Theory and practice
Frans A. Kuypers
Children’s Hospital, Oakland, CA, USA
S16: CLINICAL STUDIES OF ERYTHROCYTE DEFORMABILITY AND DISAGGREGATING SHEAR STRESS
Chairs: Kyu Chang Won and Chul Woo Ahn
S16-1Association between red blood cell deformability and diabetic complications in patients with type 2 diabetes
Jun Sung Moon, Yu Kyung Kim and Kyu Chang Won
Yeungnam University College of Medicine, Republic of Korea
S16-2Investigation of erythrocyte deformability in children with hematologic disease and hematopoietic stem cell transplantation
Jae Min Leea, Yu Kyung Kima, Jang Soo Suhb and Jeong Ok Haha
aYeungnam University, Republic of Korea
bKyungpook National University School of Medicine, Republic of Korea
S16-3Hemorheological approach for early detection of diabetic nephropathy
Seohui Leea, Ji Sun Nama, Shin Ae Kanga, Jong Suk Parka, Sehyun Shinb and Chul Woo Ahna
aGangnam Severance Hospital, Republic of Korea
bKorea University, Republic of Korea
S16-4Effect of RBC deformability and fibrinogen concentration on disaggregating shear stress
Hoyoon Leea, Gyehyu Kima, Yeonsoo Kima, Jeongho Kima, Byoung-Kwon Leeb and Sehyun Shina
aKorea University, Seoul, Republic of Korea
bGangnam Severance Hospital, Yonsei University, Republic of Korea
S16-5Deformability analysis of experimentally-fixed and sickle red blood cells
Miklos Rabaia, Jon A. Detterichb, Rosalinda B. Wenbyc, Tatiana M. Hernandezb, Kalman Totha, John C. Woodb, Jack Feinbergd and Herbert J. Meiselmanc
a1st Department of Medicine, University of Pecs, Hungary
bDepartment of Pediatrics, Children’s Hospital Los Angeles, Los Angeles, CA, USA
cDepartment of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
dDepartment of Physics and Astronomy, University of Southern California, Los Angeles, CA, USA
17:00–19:00Poster Session 2
Wednesday, May 27th
9:00–10:00Poiseuille Gold Medal Award, Ceremony and Lecture L5
Laudatio: Herbert H. Lipowsky
Award lecture: Geert W. Schmid-Schönbein: Autodigestion and proteolytic receptor cleavage in rheological and cardiovascular dysfunction
10:00–10:30Coffee Break
10:30–12:00Symposia S17–S20
S17: MICROFLUIDICS: NOVEL TOOLS FOR MEASURING DEFORMABILITY OF RED BLOOD CELLS
Chairs: Walter H. Reinhart and Sergey S. Shevkoplyas
S17-1Microfluidic technologies for high throughput analysis of red blood cell deformability
Aline Santoso, Jeong-Hyun Lee, Xiaoyan Deng, Kerryn Matthews, Han Yuan, Emel Islamzada, Sarah McFaul, Marie-Eve Myrand Lapierre, Mark Scott and Hongshen Ma
University of British Columbia, Canada
S17-2High throughput microfluidic characterization of red blood cell deformability changes during storage
C. Wanga,b, Y. Zhengb, J. Chenb, T. Cuib, N. Shehataa,b and Y. Sunb
aMount Sinai Hospital, Toronto, ON, Canada
bUniversity of Toronto, Toronto, ON, Canada
S17-3Modeling the traversal of a red blood cell through a microfluidic device
Ewan Henry, Dmitry A. Fedosov and Gerhard Gompper
Institute of Complex Systems, Research Center Jülich, Germany
S17-4Artificial microvascular network device as a new tool to measure red blood cell mechanical properties
Walter H. Reinhart, Nathaniel Z. Piety, Jennie M. Burns, Jose M. Sosa and Sergey S. Shevkoplyas
Department of Biomedical Engineering, Cullen College of Engineering, University of Houston, Houston, TX, USA
S18: EXERCISE HEMORHEOLOGY
Chairs: Michael Simmonds and Philippe Connes
S18-1Haemorheological response to consuming an alcoholic beverage following moderate exercise-induced dehydration
Michael J. Simmondsa,b, Chris Irwina,b, Jarod Horobina,b, Erica Cunninghamb, Monica Staggb and Ben Desbrowa,b
aMenzies Health Institute of Queensland, Griffith University, Queensland, Australia
bSchool of Allied Health Sciences, Griffith University, Queensland, Australia
S18-2Impact of training on red blood cell deformability in health and disease considering training scope and intensity
Marijke Grau, André Filipovic, Christina Koliamitra, Basit Ahmad, Bianca Collins, Klara Brixius and Wilhelm Bloch
Department of Molecular and Cellular Sport Medicine, Institute of Sport Medicine and Cardiovascular Research, German Sport University Cologne, Cologne, Germany
S18-3Hematocrit and exercise: Old findings, new interpretations?
Jean-Frederic Bruna, Emmanuelle Varlet-Mariea and Eric Raynaud de Mauvergerb
aUniversity of Montpellier, France
bUniversity of Montpellier, French Polynesia
S18-4Should we promote regular physical activity in sickle cell patients?
P. Connesa,b, C. Faesa, K. Charlotb, E. Charrina, M. Petrasc, E. Aufradeta, L. Doumdoc, M. Etienne-Julanc, X. Waltzb, M.D. Hardy-Dessourcesb, M. Romanab, V. Pialouxb and C. Martinb
aLaboratoire CRIS EA647, Université Lyon 1, Lyon, France
bUMR Inserm 1134, Université des Antilles et de la Guyane, Pointe-à-Pitre, Guadeloupe
cUnité Transversale de la Drépanocytose, Guadeloupe
S19: THE ENDOTHELIAL SURFACE LAYER (GLYCOCALYX) IN VASCULAR DISEASE
Chair: John M. Tarbell
S19-1Sphingosine-1-phosphate (S1P) maintains normal vascular permeability by preserving endothelial surface glycocalyx (ESG) in microvessels in vivo
Lin Zhanga, Min Zenga, Jie Fana, John M. Tarbella, Fitz-Roy E. Curryb and Bingmei M. Fua
aDepartment of Biomedical Engineering, The City College of The City University of New York, New York, NY, USA
bDepartment of Physiology and Membrane Biology, University of California, Davis, USA
S19-2Role of matrix metalloproteases on the kinetics of leukocyte–endothelium adhesion and implications for mediators of WBC rolling and firm adhesion
Herbert H. Lipowsky
Department of Biomedical Engineering, Penn State University, State College, PA, USA
S19-3Clinical assessment of glycocalyx: A tool to monitor vascular risk in patients?
Hans Vink
Department of Physiology, Maastricht University, The Netherlands
S19-4The glycocalyx, mechanotransduction and lung vascular permeability
Randal O. Dull
Department of Anesthesiology, University of Illinois College of Medicine, Chicago, IL, USA
S20: PARTICULATE FLOW IN MICRO/MINI CHANNELS
Chair: Masako Sugihara-Seki
S20-1Simulation of the dispersion of two kinds of droplets under Couette flow
Masato Makino
Yamagata University, Jonan, Yonezawa, Yamagata, Japan
S20-2Experimental studies on particle migration in channel flows
M. Sugihara-Seki, T. Kimura, R. Noso and H. Shichi
Department of Pure and Applied Physics, Kansai University, Suita, Osaka, Japan
S20-3Experimental analysis of various 3D migration phenomena of particles in micro-scale conduits using holographic microscopy
Sang Joon Lee
Center for Biofluid and Biomimic Research, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea
S20-4Lateral migration of a spherical particle in a square channel flow
R. Otomo, N. Nakagawa and M. Sugihara-Seki
Faculty of Engineering Science, Kansai University, 3-3-35 Yamate-cho, Suita, Osaka, Japan
12:00–13:00Lunch Break
(IOS Press Luncheon for Biorheology (invitation only))
13:00–17:30SOCIAL PROGRAM
18:00–18:30Arrive at ‘Some Sevit’
18:30–21:30Banquet
Thursday, May 28th
8:30–9:30Plenary Lecture L6
John M. Tarbell: Fluid mechanics, vascular disease and the glycocalyx
9:30–10:00Coffee Break
10:00–11:30Symposia S21–S23
S21: CLINICAL RELEVANCE OF BLOOD VISCOSITY MEASUREMENT, STATE OF THE ART, LIMITATION AND INTRODUCTION TO A NEW METHODOLOGY
Chair: Alexandre De Tilly
S21-1Blood rheology: Different aspects of the same elephant
Herbert J. Meiselman
Department of Physiology and Biophysics, Keck School of Medicine, Los Angeles, USA
S21-2Clinical relevance of blood viscosity
Philippe Connes
Laboratoire CRIS EA647, Université Lyon 1, Lyon, France
S21-3New aspect of blood and plasma rheology
Olivier Greffiera, Alexandre de Tillyb and Jean-Paul Decruppea
aLaboratoire LCP-A2MC EA4632, Institut Jean Barriol, Université de Lorraine, Metz, France
bBOWLT, Laboratoire d’étude de la viscosité du sang et des liquides complexes, Hong Kong
S21-4A set of reliable measurements of blood viscosity
Alexandre De Tilly
BOWLT, Laboratoire d’étude de la viscosité du sang et des liquides complexes, Hong Kong
S22: CHANNELS AT THE BASE OF IT ALL: FUNDAMENTAL MECHANISMS OF MEMBRANE STRETCH ACTIVATED CHANNELS
Chairs: Peter J. Butler and Chilman Bae
S22-1Integrating cellular mechanobiology and biomechanics: Emergence of primary cilia as mechanosensors
C.R. Jacobs and A. Nguye
Department of Biomedical Engineering, Columbia University, New York, NY, USA
S22-2PIEZO: Eukaryotic mechanosensitive ion channel
Chilman Bae
Department of Physiology and Biophysics, State University of New York at Buffalo, NY, USA
S22-3Fluorescence lifetime fluctuations as a new method for in situ measurement of membrane bending modulus
Hari S. Muddanaa, Changjin Huangb, Selva Jeganathana, Sulin Zhangb and Peter J. Butlera
aDepartment of Biomedical Engineering, Penn State University, PA, USA
bDepartment of Engineering Science and Mechanics, Penn State University, PA, USA
S22-4Determining how PIEZO1 channels sense force: Force-from-lipids?
C.D. Coxa, P. Gottliebb and B. Martinaca,c
aVictor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia
bDepartment of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, NY, USA
cSt Vincent’s Clinical School, University of New South Wales, Darlinghurst, NSW 2010, Australia
S23: OCT APPLICATION IN PATIENT-SPECIFIC COMPUTATIONAL HEMORHEOLOGY
Chair: Joon Sang Lee
S23-1The effects of aggregation characteristics of vesicles on their rheological properties using a computational approach
Joon Sang Lee
Department of Mechanical Engineering, Yonsei University, Republic of Korea
S23-2Supercomputing and medical data in clinical practice on circulatory diseases
Sang Min Leea, Hyungwook Parka and Joon Sang Leeb
aDepartment of Supercomputing Modeling and Simulation, Korea Institute of Science & Technology Information, Republic of Korea
bSchool of Mechanical Engineering, Yonsei University, Republic of Korea
S23-3Clinical application of 3D OCT
Jung-Sun Kim
Department of Cardiology, Yonsei University and Severance Hospital, Republic of Korea
S23-4Advances in functional optical coherence tomography
Chulmin Joo
Department of Mechanical Engineering, Yonsei University, Republic of Korea
11:30–12:30Free Communications O4–O6
O4: CELLULAR AND MOLECULAR BIOMECHANICS
Chair: Chulmin Joo
O4-1Altered membrane skeleton protein binding affinity by protein 4.1 phosphorylation plays a potential role in the deformability of vertebrate erythrocytes
Fuzhou Tang, Yang Ren, Ruofeng Wang, Xueru Deng and Xiang Wang
Department of Biomedical Engineering, Chongqing University, Chongqing, China
O4-2Investigating the molecular mechanisms of membrane vesiculation and cell deformability after microvesiculation
Duangdao Palasuwan and Attakorn Palasuwan
Department of Clinical Microscopy, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand
O4-3Mechanical regulation of kinetics and structural bases of beta2 integrin–ICAM-1 interaction
Shouqin Lü, Debin Mao, Ning Li, Xiao Zhang and Mian Long
Center of Biomechanics and Bioengineering and Key Laboratory of Microgravity (National Microgravity Laboratory), Institute of Mechanics, Chinese Academy of Sciences, Beijing, China
O4-4Force generation and morphology of actomyosin machinery
T. Kim
Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA
O5: MECHANICS OF BLOOD COMPONENTS
Chair: Brian Cooke
O5-1Effects of secoisolariciresinol on blood viscosity, aggregation and deformability of RBCs in ovariectomised rats
T.M. Plotnikovaa, A.M. Anishchenkob, O.I. Alievb, N.E. Nifantievc and M.B. Plotnikovb
aSiberian State Medical University, Tomsk, Russia
bE.D. Goldberg Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia
cN.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia
O5-2Diversity of biomechanical and nanostructural changes to human and cynomolgus monkey red cells infected with malaria parasites
Rou Zhanga, Eric Lombardinib, Amirah Amirc, Georges Snounoud, Laurent Reniae, Brian M. Cookef, Mun Yik Fongc, Yee Ling Lauc, Francois Nosteng and Bruce Russella
aNational University of Singapore, Singapore
bArmed Forces Research Institute of the Medical Sciences (USAMC-AFRIMS), Thailand
cUniversity of Malaya, Malaysia
dSorbonne Universités, UPMC Université Paris 06, UPMC UMRS CR7, F-75005, France
eA*STAR, Singapore
fMonash University, Australia
gShoklo Malaria Research Unit, Mae Sod, Thailand
O5-3Observation of morphological changes on platelets exposed to shear stress
Hoyoon Leea, Jeongho Kima, Jung Hun Kimb, Hye-Sun Parkb, Chae-Seung Limc and Sehyun Shina,c
aSchool of Mechanical Engineering, Korea University, Seoul, Republic of Korea
bRheomeditech Inc., Seoul, Republic of Korea
cDepartment of Laboratory Medicine, Korea University Guro Hospital, Seoul, Republic of Korea
O5-4The influence of fluid shear stress on the Von Willebrand factor protein in an optical trap
Xavier J. Candelaa, Monica Corsettia, Peter J. Butlera and Keefe B. Manninga,b
aDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, PA, USA
bDepartment of Surgery, Penn State Hershey Medical Center, Hershey, PA, USA
O6: DISEASE AND HEMORHEOLOGY
Chair: Tamas Alexy
O6-1Comparative efficiency and hemorheological consequences of radiotherapy and chemotherapy in patients with solid nonmyeloid malignancies
I.A. Tikhomirovaa, A.V. Muravyova, S.V. Cheporovb, N.V. Kislovb and E.P. Petrochenkoa
aState Pedagogical University, Yaroslavl, Russia
bRegional Cancer Hospital, Yaroslavl, Russia
O6-2Autodigestion and proteolytic receptor cleavage in rheological and cardiovascular dysfunction
Geert W. Schmid-Schönbein, Frank A. DeLano, Marco H. Santamaria, Angela Y. Chen, Edward E. Tran and Stephen F. Rodrigues
Department of Bioengineering, University of California San Diego, La Jolla, CA, USA
O6-3Adhesion of mesenchymal stem cells from flowing blood: Effects of their tissue origin and of interactions with platelets
Asma Alanazia,b, Hafsa Munira, Helen M. McGettricka, N. Thin Luua, Steve P. Watsona and Gerard B. Nasha
aCollege of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
bKing Saud bin Abdulaziz University for Health Sciences, Riyadh, KSA
O6-4Endothelial microparticles released in response to TNF-α vary in miRNA content and physical characteristics: Implications for their role as intercellular communicators
Tamas Alexy, Warren D. Gray, Kimberly Rooney, Martina Weber and Charles D. Searles
Emory University School of Medicine, Atlanta, GA and Atlanta VA Medical Center, Decatur, GA, USA
12:30–14:00Lunch Break
(IOS Press Luncheon for Clin Hemorheol (invitation only))
14:00–15:00Plenary Lecture L7
Takeo Matsumoto: Mechanical heterogeneity in the aortic wall: From macroscopic to microscopic viewpoint
15:00–15:30Coffee Break
15:30–17:00Symposia 24–26
S24: MICRO/NANO BIOMECHANICS
Chair: Toshiro Ohashi
S24-1Traction force measurement of migrating fibroblasts using a microchannel device
Toshiro Ohashi
Faculty of Engineering, Hokkaido University, Japan
S24-2Construction of microvascular networks under controlled culture microenvironments
Ryo Sudo
Department of System Design Engineering, Keio University, Japan
S24-3Quantification of interactions between red blood cells in solutions of blood plasma proteins and in autologous plasma by single cell force microscopy
Kisung Leea, Matti Kinnunenb, Maria Dmitrievna Khokhlovaa, Evgeny Valerevich Lyubina, Andrey Anatolevich Fedyanina, Artashes Vacheevich Karmenyanc and Alexander Vasilievich Priezzheva
aLomonosov Moscow State University, Russian Federation
bUniversity of Oulu, Finland
cNational Dong Hwa University, Taiwan
S24-4Mechanical regulation of kinetics and structural bases of beta2 integrin–ICAM-1 interaction
Shouqin Lü, Debin Mao, Ning Li, Xiao Zhang and Mian Long
Center of Biomechanics and Bioengineering and Key Laboratory of Microgravity (National Microgravity Laboratory), Institute of Mechanics, Chinese Academy of Sciences, Beijing, China
S25: STIMULI-RESPONSIVE BIOLOGICAL SOFT MATTER
Chairs: Yasuyuki Maki and Takayuki Narita
S25-1Stress-responsive gel–sol transformation of serum albumin in aqueous ethanol solution
Yasuyuki Maki, Kazuki Yajima and Toshiaki Dobashi
Gunma University, Tenjin, Kiryu, Gunma, Japan
S25-2Rheological behavior of super-hydrophilic mucin from loach skin mucus
Miao Du
Department of Polymer Science and Engineering, Zhejiang University, China
S25-3Measurement of blood physical properties in a microfluidic environment
B.J. Kima, J.C. Hyunb, A. Zhbanovb and S. Yanga,b
aDepartment of Medical System Engineering, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea
bSchool of Mechatronics, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea
S25-4Morphogenesis formed from alginate solutions in capillary glass tubes
Takayuki Naritaa, Natsuki Matsudaa, Masayuki Tokitab and Yushi Oishia
aDepartment of Chemistry and Applied Chemistry, Saga University, 1 Honjo, Saga, Japan
bDepartment of Physics, Kyushu University, Hakozaki, Fukuoka, Japan
S26: SICKLE CELL DISEASE, BLOOD RHEOLOGY AND PATOPHYSIOLOGY
Chairs: Thomas D. Coates and Philippe Connes
S26-1Peripheral vasoconstriction and abnormal parasympathetic response to pain and mental stress in sickle cell disease: Could the autonomic nervous system trigger sickle cell crisis?
Thomas D. Coatesa, Maha Khaleela, Mammen Puliyela, Patjanaporn Chalachevad, Roberta Katob, Wanwara Thuptimdangd, John Sunwood, Adam Bushd, Jon A. Detterichc, Payal Shaha, Herbert J. Meiselmane, Jenny Tsaof, John C. Woodc,d, Richard Spostoa, Lonnie Zeltzerf and Michael C.K. Khood
aDivision of Hematology, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
bDivision of Pulmonology, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
cDivision of Cardiology, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
dDepartment of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA
eDepartment of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
fDepartment of Pediatrics, University of California, Los Angeles, CA, USA
S26-2Red blood cell deformability and blood viscosity determine tissue oxygenation in sickle cell disease
J. Dettericha, M. De Zoysab, A. Busha, R. Katoc, T. Coatesd and J. Wooda
aDivision of Cardiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
bKeck School of Medicine, University of Southern California, Los Angeles, CA, USA
cDivision of Pulmonology, Children’s Hospital Los Angeles, CA, USA
dDivision of Hematology, Children’s Hospital Los Angeles, CA, USA
S26-3The development of a low-powered, portable, and inexpensive red blood cell aggregometer
Juan M. Arrietaa, Surendran Sabapathyb, Ozlem Yalcinc, Guillermo Jacuindea and Michael Simmondsb
aSchool of Allied Health Sciences, Griffith University, Australia
bHeart Foundation Research Centre, Menzies Health Institute of Queensland, Griffith University, Australia
cDepartment of Physiology, Koc University, Istanbul, Turkey
S26-4The association of sickle cell trait with type 2 diabetes severely impairs blood rheology and vascular function
Mor Diawa, Vincent Pialouxb,g,h, Cyril Martinb,h,*, Abdoulaye Samba,c,*, Saliou Diopd, Camille Faesb,h, Pauline Muryb,h, Niama Sall Diope, Saïd-Norou Diopf, Maïmouna Ndour Mbayef and Philippe Connesb,g,h
*Equal contributors
aLaboratoire de physiologie et explorations fonctionnelles, FMPO, UCAD, Dakar, Sénégal
bCRIS EA 647 Laboratory, University Claude Bernard Lyon 1, Villeurbanne, France
cUMI 3189, Environnement, Santé, Sociétés, Université Bamako-UCAD, Dakar, Sénégal
dLaboratoire d’hémato-immunologie, FMPO, UCAD, Dakar, Sénégal
eLaboratoire de biochimie et de biologie moléculaire, FMPO, UCAD, Dakar, Sénégal
fClinique Médicale II, Centre Hospitalier Abass Ndao, Dakar, Sénégal
gInstitut Universitaire de France, Paris, France
hLaboratory of Excellence in Red Blood Cell (LABEX GR-Ex), PRES Sorbonne, Paris, France
17:00–17:30CLOSING SESSION
Poster Session 1
P1-1Regional specific adaptation of the vascular cell glycocalyx in tail-suspended rats
Hongyan Kang and Xiaoyan Deng
School of Biological Science and Medical Engineering, Beihang University, China
P1-2The mechano-biological role of caveolae/caveolin-1 in low shear stress-induced migration and invasion of human breast carcinoma MDA-MB-231 cells
Liuyuan Guan, Fenglong Zhao, Niya Xiong, Yu Chen, Hong Yang, Chunhui Wu and Yiyao Liu
Department of Biophysics, School of Life Science and Technology, University of Electronic Science and Technology of China, China
P1-3Low shear stress induces breast cancer MDA-MB-231 cell motility and cytoskeleton remodeling via PI-3K/Akt/mTOR/p70S6K signal pathway
Fenglong Zhao, Niya Xiong, Liuyuan Guan, Yu Chen, Jing Zhang, Hong Yang, Chunhui Wu and Yiyao Liu
Department of Biophysics, School of Life Science and Technology, University of Electronic Science and Technology of China, China
P1-4Protective effect of propolis on erythrocyte rheology in experimental mercury intoxication in rats
S. Aydoğana, S. Silicib, K. Ercişa and A.T. Atayoğluc
aDepartment of Physiology, Faculty of Medicine, Erciyes University, Kayseri, Turkey
bDepartment of Agricultural Biotechnology, Agricultural Faculty, Erciyes University, Kayseri, Turkey
cDepartment of Family Medicine, American Hospital, Istanbul, Turkey
P1-5Effect of membrane mechanical properties of red blood cells on oxygen transfer
Xiaobo Gonga, Zhaoxin Gonga and Huaxiong Huangb
aDepartment of Engineering Mechanics, Shanghai Jiao Tong University, China
bDepartment of Mathematics & Statistics, York University, China
P1-6The effect of exercise on blood fluidity
Tatsushi Kimuraa, Hironobu Hamadab, Shunsuke Taitoc, Makoto Takahashib and Kiyokazu Sekikawab
aDepartment of Early Childhood Education, Yasuda Women’s College, Japan
bDepartment of Physical Analysis and Therapeutic Sciences, Hiroshima University, Japan
cDivision of Clinical Support, Hiroshima University Hospital, Japan
P1-7Rapid rather than gradual weight reduction impairs performance of Taekwondo Athletes through a reduction in red blood cell-nitric oxide synthase dependent nitric oxide production and has a negative effect on hemorheological parameters
Woo-Hwi Yangb,d, Oliver Heined, Sebastian Paulya, Pilsang Kima, Wilhelm Blocha,c, Joachim Mesterb,c and Marijke Graua,c
aDepartment of Molecular and Cellular Sport Medicine, Institute of Cardiovascular Research and Sport Medicine, German Sport University Cologne, Cologne, Germany
bInstitute of Training Science and Sport Informatics, German Sport University Cologne, Cologne, Germany
cGerman Research Centre for Elite Sports, German Sport University, Cologne, Germany
dOlympic Training Centre Rhineland, Cologne, Germany
P1-8Suspension state promotes the malignant potential of MDA-MB-231 cells
Xiaomei Zhang and Yonggang Lv
Key Laboratory of Biorheological Science and Technology, Chongqing University, Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400044, China
P1-9The features of peripheral blood flow in cancer
I.A. Tikhomirovaa, D.V. Lileevb, N.B. Kislovb, I.A. Gordeevb, M.E. Schekalevab and Yu.V. Malyshevaa
aMedicine & Biology Department, State Pedagogical University, Yaroslavl, Russia
bYaroslavl Regional Cancer Hospital, Yaroslavl, Russia
P1-10Mechano-growth factor E peptide promoted rat tenocyte motility via the FAK-ERK1/2 signaling pathway
Bingyu Zhang, Qing Luo, Li Yang and Guanbin Song
Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, China
P1-11Flow characteristics of a shear-thinning blood analog in post-stenosis region
Hyung Kyu Huh, Ho Jin Ha and Sang Joon Lee
Department of Mechanical Engineering, Center for Biofluid and Biomimic Research, Pohang University of Science and Technology, Pohang, Republic of Korea
P1-12Simultaneous measurement of RBC aggregation and blood viscosity under ex vivo condition
Eunseop Yeom and Sang Joon Lee
Pohang University of Science and Technology, Republic of Korea
P1-13Influence of mechanical stimulation by different sound wave frequencies on growth of vascular endothelial cells during in vitro culture
Yang Ren, Ruofeng Wang, Fuzhou Tang, Xueru Deng and Xiang Wang
Chongqing University Biomedical Engineering, Chongqing, China
P1-14Dynamics of prismatic particles in linear shear flow near a wall
Jiyeon Hyun and Sei-Young Lee
Yonsei University, Republic of Korea
P1-15Membrane structural protein analysis and mechanical property analysis of rat erythroblasts in different developmental stages
Xueru Deng, Fuzhou Tang, Yang Ren, Ruofeng Wang and Xiang Wang
Department of Biomedical Engineering, Chongqing University, Chongqing, China
P1-16Effects of magnetism and body acceleration on blood flows and its applications in human physiology
Rangarao N. Pralhada and Meena Sharad Kaulgib
aDefence Research and Development Organisation, India
bD.Y. Patil College of Engineering, Akrudi Pune India, India
P1-17An alternative, rapid method for evaluation of erythrocyte sedimentation rate
Alexander Zhbanova and Sung Yanga,b
aDepartment of Medical System Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju, Republic of Korea
bSchool of Mechatronics, Gwangju Institute of Science and Technology (GIST), Gwangju, Republic of Korea
P1-18The effect of intracellular signaling mechanisms on oxygen-carrying properties of the erythrocyte
G. Yavasa, M.J. Simmondsb, H.J. Meiselmanc and O. Yalcina
aKoc University School of Medicine, Istanbul, Turkey
bHeart Foundation Research Centre, Griffith Health Institute, Griffith University, Queensland, Australia
cDepartment of Physiology and Biophysics, Keck School of Medicine, Los Angeles, CA, USA
P1-19Facilitated solute removal by a new pumping operation during single needle hemodialysis
Seiichi Mochizukia, Takehito Ogawaa, Chihiro Fujiharab and Jun-ichi Onoa
aKawasaki University of Medical Welfare, Kurashiki, Japan
bOkayama University Hospital, Okayama, Japan
P1-20Substrate stiffness alters cell behavior and mechanical character of cells from normal human liver
Tingting Xiaa,b, Hui Zhoua,b, Qiping Huanga,b, Hongbing Wanga,b, Guanglei Yud, Xiaobing Zouc, Zhiling Xua,b and Li Yanga,b
aKey Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, China
b‘111’ Project Laboratory of Biomechanics and Tissue Repair, Bioengineering College, Chongqing University, Chongqing, China
cCollege of Chemistry and Chemical Engineering, Chongqing University, Chongqing, China
dCollege of Mathematics and Statistics, Chongqing University, Chongqing, China
P1-21Enhanced inflammatory mediators and platelet activation in unstable angina
Xiaojuan Ma
Xiyuan Hospital and China Academy of Chinese Medicine Sciences, China
P1-22Exercise-induced changes in hematocrit and hematocrit/viscosity ratio in male rugby players
Jean-Frederic Brun, Emmanuelle Varlet-Marie and Eric Raynaud de Mauverger
Department of Physiology, University of Montpellier, France
P1-23Striped morphosis observed in collagen gels formed in a small space
Honami Takajoa, Kazuya Furusawab, Yushi Oishia and Takayuki Naritaa
aDepartment of Chemistry and Applied Chemistry, Saga University, Japan
bDepartment of Biological Science, Hokkaido University, Japan
P1-24A non-Newtonian standard imitating the rheological characteristics of blood for hemorheology tests
Ruofeng Wang, Fuzhou Tang, Pei Xu, Yang Ren, Xueru Deng and Xiang Wang
Department of Biomedical Engineering, Chongqing University, Chongqing, China
P1-25One-year follow-up of blood viscosity factors and hematocrit/viscosity ratio in elite soccer players
Jean-Frederic Brun, Emmanuelle Varlet-Marie and Eric Raynaud de Mauverger
Department of Physiology, University of Montpellier, Montpellier, France
P1-26Blood damage assessment as gauged by erythrocyte microparticle formation during sub-hemolytic mechanical trauma
D.K. Burk and E.A. O’Rear
Department of Chemical, Biological and Materials Engineering, University of Oklahoma, USA
P1-27SDF-1/CXCR4 axis and MAPK signaling pathway mediate lower shear stress-induced the migration of bone marrow-derived mesenchymal stem cells
Guanbin Songa, Yuan Lina, Qing Luoa, Li Yanga, Naoya Sakamotob and Masaaki Satoc
aKey Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, China
bGraduate School of Biomedical Engineering, Tohoku University, Sendai, Japan
cDepartment of Medical Engineering, Kawasaki University of Medical Welfare, Okayama, Japan
P1-28Simulated microgravity induces cell apoptosis of the breast cancer cells by activating Rac1 and Bcl-2
Zhenhui Kanga, Xiangdong Luob, Tong Qin, Yong Yangb, Yongfei Liua and Guixue Wanga
aCollege of Bioengineering, Chongqing University, Chongqing, China
bState Key Laboratory of Trauma, Burns and Combined Injury, Third Military Medical University, China
P1-29Is the stiffness of substrate involved in the interaction of MSCs and HSCs in vitro?
Qiping Huang, Quanyi Feng, Tingting Xia, Hao Wang and Dongliang Shen
Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, China
P1-30Transforming growth factor- β1 remodel the cytoskeleton organization of mature dendritic cells via Smad signaling pathway
Hui Yanga, Zhu Zenga, Rong Donga, Cui Fang Wua, Jin Hua Longb, Xiao Li Xua, Hui Xuea, Zu Quan Hua and Wei Juan Yaoc
aSchool of Biology & Engineering, Guiyang Medical University, China
bAffiliated Cancer Hospital, Guiyang Medical College, China
cCenter of Hemorheology, School of Basic Medical Sciences, Health Science Center of Peking University, China
P1-31Sequence of changes in viscosity of blood, blood pressure, and vasodilator function of endothelium in young SHR
M.B. Plotnikova, O.I. Alieva, A.M. Anishchenkoa, A.V. Sidekhmenovaa, A.Y. Shamanaeva and T.M. Plotnikovab
aE.D. Goldberg Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia
bSiberian State Medical University, Tomsk, Russia
P1-32Haemochromatosis does not impair the haemorheological properties of blood
Antony McNameea, Surendran Sabapathyb, Jarod Horobinb, Indu Singhb, Janelle Guerrerob and Michael Simmondsb
aSchool of Allied Health Sciences, Griffith University, Australia
bHeart Foundation Research Centre, Menzies Health Institute of Queensland, Griffith University, Australia
P1-33Rheological properties of synthetic mucin solutions as simulated normal and asthmatic airway mucus
Zhiwei Liu and Linhong Deng
Changzhou Key Laboratory of Respiratory Medical Engineering, Institute of Biomedical Engineering and Health Sciences, Changzhou University, Changzhou, Jiangsu, China
P1-34Comparison of blood flows determined by a computational model and measured by ultrasonography
Shiori Yauchia, Kiyomi Nikia, Motoaki Sugawarab, Fuyou Liangc and Mari Ohshimad
aTokyo City University Graduate School, Japan
bHimeji Dokkyo University, Japan
cShanghai Jiao Tong University, China
dThe University of Tokyo, Tokyo, Japan
P1-35An experimental study of flow around submerged grass vegetation
Julia Seungmi Lee
School of Engineering, Brown University, USA
Poster Session 2
P2-1Effect of rice powder on the rheological properties of Gomatofu (sesame tofu)
Emiko Sato
University of Niigata Prefecture and Faculty of Human Life Studies, Japan
P2-2Analysis of blood pressure waves in a stenosis by CFD
Young Woo Kim and Joon Sang Lee
Yonsei University, Republic of Korea
P2-3Ultrasonic observation of erythrocyte aggregation in an elastic carotid artery bifurcation phantom under pulsatile flow
Changzhu Jina, Soo-Hong Mina, Dong-Guk Paenga and Alfred C.H. Yub
aOcean System Engineering, Jeju National University, Republic of Korea
bEEE Department, Hong Kong University, Hong Kong
P2-4Functional recirculation phenomena during single needle dialysis
Chihiro Fujiharaa, Seiichi Mochizukib, Takehito Ogawab and Jun-ichi Onob
aOkayama Department of Blood Purification Center, Okayama University Hospital, Okayama, Japan
bKawasaki University of Medical Welfare, Kurashiki, Japan
P2-5Sickle cell anemia and red blood cell deformability determined by ektacytometry
Nermi Parrowa, Céline Renouxb,c, Camille Faesc, Philippe Jolyb,c, Max Hardemand, John Tisdalea, Mark Levinea, Nathalie Garniere, Yves Bertrande, Kamila Kebailie, Daniela Cuzzubboe, Cyril Martinc, Vincent Pialouxc and Philippe Connesc
aNational Institutes of Health, Washington, DC, USA
bLaboratoire de Biochimie, Hôpital Edouard Herriot, Lyon, France
cLaboratoire CRIS EA647, Université Lyon 1, Lyon, France
dAcademic Medical Center, Amsterdam, The Netherlands
eInstitut d’Hématologie et d’Oncologie Pédiatrique, Lyon, France
P2-6Different systolic blood pressure changes post-stenotic cerebral blood flow in patients with intracranial atherosclerosis
Hyo Suk Nama, Fabien Scalzob, Xinyi Lengc and David Liebeskindb
aDepartment of Neurology, College of Medicine, Yonsei University, Republic of Korea
bNeurovascular Imaging Research Core, University of California, Los Angeles, USA
cDepartment of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong
P2-7A three dimensional microfluidic model to investigate synergism of biomechanical and biochemical factors on angiogenic sprouting
Minhwan Chung, Sudong Kim, Jungho Ahn and Noo Li Jeon
Seoul National University, Republic of Korea
P2-8Signaling pathway implied on the vasodilator effect of a selective β1 adrenoceptor blocker in smooth muscle cells: Involvement of actin cytoskeleton, myosin light chains and Rho-A kinase
A. Kadia, N. De Islaa, P. Lacolleyb, J.F. Stoltza,c and P. Menua
aUMR 7365 CNRS-Université de Lorraine, Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), Vandoeuvre-lès-Nancy, France
bUMR 1116 INSERM – Laboratoire de Pharmacologie Cardiovasculaire, Vandoeuvre-lès-Nancy, France
cCHU Nancy – Cell and Tissue Therapy Unit and Tissue Bank, Vandoeuvre-lès-Nancy, France
P2-9A microfluidic platform for quantitative analysis of metastasis
Hyunjae Lee, Woohyun Park, Hyunryul Ryu, Minhwan Chung and Noo Li Jeon
Seoul National University, Republic of Korea
P2-10Disturbed flow-induced p90RSK activation elicits endothelial dysfunction and atherosclerosis formation via inhibiting de-SUMOylation enzyme SENP2
Kyungsun Heo and Jun-ichi Abe
Department of Cardiology, University of Texas MD Anderson Cancer Center, Houston, TX, USA
P2-11Macro- and micro-circulatory adaptation in response to chronic hypoxia
Saki Hamashima and Masahiro Shibata
Division of Systems Engineering and Science, Shibaura Institute of Technology, Japan
P2-12Platelet activation by collagen and fibrinogen coated beads
Gyehyu Kima, Hoyoon Leea, Jeongho Kima, Jung Hun Kimb, Hye-Sun Parkb, Chae-Seung Limc and Sehyun Shina,c
aSchool of Mechanical Engineering, Korea University, Republic of Korea
bRheomeditech, Inc., Seoul, Republic of Korea
cDepartment of Laboratory Medicine, Korea University Guro Hospital, Seoul, Republic of Korea
P2-13Examination of the effects of stirring geometry on platelet activation and aggregation
Jeongho Kima, Gyehyu Kima, Hoyoon Leea, Yeonsoo Kima and Sehyun Shina,b
aSchool of Mechanical Engineering, Korea University, Seoul, Republic of Korea
bDepartment of Laboratory Medicine, Korea University Guro Hospital, Seoul, Republic of Korea
P2-14Light-transmission based detection of platelet activation in a stirring microchip system
Jeongho Kima, Hoyoon Leea, Gyehyu Kima, Yeonsoo Kima and Sehyun Shina,b
aSchool of Mechanical Engineering, Korea University, Seoul, Republic of Korea
bDepartment of Laboratory Medicine, Korea University Guro Hospital, Seoul, Republic of Korea
P2-15Experimental measurements of the particle lateral migration in submillimeter channel flows
Hiroyuki Shichia, Junji Sekib, Tomoaki Itanoa and Masako Sugihara-Sekia
aDepartment of Pure and Applied Physics, Kansai University, Suita, Osaka, Japan
bORDIST, Kansai University, Suita, Osaka, Japan
P2-16Cross-sectional distributions of platelets in blood flow through microchannels
Tomoya Kimuraa, Ryota Nosoa, Keisuke Sakamotoa, Junji Sekib and Masako Sugihara-Sekia
aDepartment of Pure and Applied Physics, Kansai University, Suita, Osaka, Japan
bORDIST, Kansai University, Suita, Osaka, Japan
P2-17Finite element analysis of physiological blood flow through an aneurysm
Deok-Kee Choi
Department of Mechanical Engineering, Dankook University, Republic of Korea
P2-18Study of an alternative pyrogen test for blood product
Ji Hye Kim and Chi-Young Ahn
Blood Product Team, National Center for Lot Release, NIFDS, Ministry of Food and Drug Safety, Republic of Korea
P2-19Comparative investigations for evaluating red blood cell deformability alterations related to splenectomy and various spleen-preserving operation types in a follow-up study, using filtrometry, slit-flow and rotational ektacytometry
Iren Mikoa, Eniko Totha, Ferenc Kissa, Istvan Furkaa, Andrea Furkab, Katalin Petoa and Norbert Nemetha
aDepartment of Operative Techniques and Surgical Research, Institute of Surgery, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
bDivision of Radiotherapy, Department of Clinical Oncology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
P2-20Improvement of the intestinal microcirculation by inhibition of endogenous cannabinoid degradation in experimental sepsis
Hyewon Yang, Juan Zhou and Christian Lehmann
Dalhousie University, Canada
P2-21Investigation of influences of flow field in the port of hemofilters on thrombus formation
Azuma Takahashi, Kiyotaka Iwasaki, Sara Suzuki, Yusuke Aoyama, Yuki Matsuhashi, Mayuki Hirata, Yoshiki Yamamoto and Mitsuo Umezu
Department of Advanced Biomedical Sciences, Waseda University, Japan
P2-22Dynamic response of viscoelastic fluids at a mesoscopic scale
Pamela Vazquez and Gabriel Caballero
Department of Biomedical Engineering and Physics, CINVESTAV, IPN, Mexico
P2-23The comparison of hemorheological parameters determined from K2- and K3-EDTA anticoagulated healthy human blood samples
Ferenc Kissa, Kornel Miszti-Blasiusb and Norbert Nemetha
aDepartment of Operative Techniques and Surgical Research, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
bInstitute of Laboratory Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
P2-24Micro-rheological characterization of selected erythrocyte-related hematological disorders: Preliminary results
Ferenc Kissa, Kornel Miszti-Blasiusb and Norbert Nemethc
aDepartment of Operative Techniques and Surgical Research, Institute of Surgery, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
bInstitute of Laboratory Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
P2-25Micro-rheological alterations in leukocyte-related myeloproliferative hematological malignancies: Preliminary results
Kornel Miszti-Blasiusa, Ferenc Kissb, Robert Szaszc and Norbert Nemethb
aInstitute of Laboratory Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
bDepartment of Operative Techniques and Surgical Research, Institute of Surgery, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
cDivision of Hematology, 2nd Department of Medicine, Institute of Internal Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
P2-26Analysis of emulsion elasticity under oscillatory shear stresses
Se Bin Choi, Young Woo Kim and Joon Sang Lee
Department of Mechanical Engineering, Yonsei University, Republic of Korea
P2-27Flow field simulations and hemolysis estimations for the FDA CPI CFD/blood damage project
Margaret Heck, Dimitrios V. Papavassiliou, Edgar A. O’Rear and Allen W. Yen
School of Chemical, Biological and Materials Engineering, University of Oklahoma, Norman, USA
P2-28Adaptations of fibrinolytic factors to preparation and competition periods in professional soccer players
Sajad Ahmadizad, Davar Rezaeimanesh and Khosrow Ebrahim
Department of Exercise Physiology, Faculty of Sport and Exercise Sciences, Shahid Beheshti University, Iran
P2-29Fibrinolytic responses to acute simulated soccer exercise in professional players
Sajad Ahmadizad, Davar Rezaeimanesh and Khosrow Ebrahim
Department of Exercise Physiology, Faculty of Sport and Exercise Sciences, Shahid Beheshti University, Iran
P2-30Differences in the beat-to-beat photoplethysmographic waveform indices between normal and metabolic-syndrome subjects
Hsin Hsiu
Graduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology, Taiwan
P2-31Effect of shear stress on osmotic deformability
Sehyun Shin, Yujin Heo, Hoyoon Lee, Yeonsoo Kim and Kehyu Kim
Department of Mechanical Engineering, Korea University, Republic of Korea
P2-32Effects of lipopolysaccharide treatment of mice on RBC elongation at different shear stresses
Yun-hee Kima, Woon-young Kima, Jei-hak Myungb, Jae-kwan Lima, Sung-mook Yooa, Seol-ju Parka and Choon-Hak Lima
aKorea University College of Medicine, Ansan, Republic of Korea
bSchool of Medicine, Korea University, Seoul, Republic of Korea
P2-33Effect of clinical and RBC hemorheological parameters on myocardial perfusion in patients with type 2 diabetes mellitus
Minhee Choa, Sehyun Shinb and Byoung-Kwon Leea
aDepartment of Internal Medicine, Gangnam Severance Hospital, Yonsei University, Republic of Korea
bDepartment of Mechanical Engineering, Korea University, Republic of Korea