Affiliations: Institute of Genetics and Biochemistry, Federal University of Uberlândia, Uberlândia, MG, Brazil | Department of Mathematics, Federal University of Uberlândia, Uberlândia, MG, Brazil
Note: [] Address for correspondence: Dr. Nilson Penha-Silva, Federal University of Uberlândia, Institute of Genetics and Biochemistry, Av. Para, 1720, Uberlândia, MG, 38400-902, Brazil. Tel.: +55 34 3218 2203, ext. 23; E-mail: [email protected]
Abstract: The observation that the fluidity must remain within a critical interval, outside which the stability and functionality of the cell tends to decrease, shows that stability, fluidity and function are related and that the measure of erythrocyte stability allows inferences about the fluidity or functionality of these cells. This study determined the biochemical and hematological variables that are directly or indirectly related to erythrocyte stability in a population of 71 volunteers. Data were evaluated by bivariate and multivariate analysis. The erythrocyte stability showed a greater association with hematological variables than the biochemical variables. The RDW stands out for its strong correlation with the stability of erythrocyte membrane, without being heavily influenced by other factors. Regarding the biochemical variables, the erythrocyte stability was more sensitive to LDL-C. Erythrocyte stability was significantly associated with RDW and LDL-C. Thus, the level of LDL-C is a consistent link between stability and functionality, suggesting that a measure of stability could be more one indirect parameter for assessing the risk of degenerative processes associated with high levels of LDL-C.
