Affiliations: Wisconsin Institute for Discovery, University of Wisconsin–Madison, Madison, WI, USA | Polymer Engineering Center, Department of Mechanical Engineering, University of Wisconsin–Madison, Madison, WI, USA | School of Material Science and Engineering, Zhengzhou University, Henan, China | Department of Medicine, School of Medicine and Public Health, University of Wisconsin–Madison, Madison, WI, USA
Note: [] Address for correspondence: Dr. Lih-Sheng Turng, BIONATES Research Theme Leader, Wisconsin Institute, for Discovery, 330 N. Orchard Street, Madison, WI 53715, USA. Tel.: +1 608 316 4310; Fax: +1 608 316 4306; E-mail: [email protected].
Abstract: Piezoresistance describes the change of electrical resistance in a material undergoing deformation. Heterogeneous materials having different resistivities of dispersed and continuous matrix phases, such as blood (comprised of red and white blood cells and platelets suspended in plasma), can exhibit the piezoresistance effect. For an initially isotropic material, two independent intrinsic material coefficients, λ1 and λ2, would uniquely describe the piezoresistance phenomenon. Materials undergoing deformation affect a material's resistivity in two ways: (a) by introducing anisotropy in the material, which is characterized by λ1 and (b) by changing the volume density of the inclusions, which is associated with (1/3 λ1+λ2). In this paper, the piezoresistance effect in bovine blood samples is studied under oscillatory shear flow with a planar sensor rosette. The first piezoresistance coefficient, λ1, was measured at various frequencies and shear rates in the blood flow and compared with cos δ (equal to G′/G*, where G′ and G* are the storage and complex moduli, respectively), which reflects the degree of elasticity. The coefficient λ1 was found to have a trend similar to that of cos δ under all conditions tested. Thus λ1 might potentially be used to characterize the viscoelastic properties of blood and the deformability of red blood cells, thus clarifying pathophysiology and facilitating diagnosis.
