The Superposition of Steady on Oscillatory Shear and Its Effect on the Viscoelasticity of Human Blood and a Blood-Like Model Fluid

Article type: Research Article

Authors: Vlastos, G.^a | Lerche, D.^{b; *} | Koch, B.^b

Affiliations: [a] Institute for Medical Physics and Biophysics, University Hospital Charité, Humboldt University, Berlin, Germany | [b] L.U.M. GmbH, Berlin, Germany

Note: [*] Reprint requests to: Professor Dietmar Lerche, L.U.M. GmbH, Rudower Chaussee 5 (IGZ), D-12489 Berlin, Germany; Fax: 49 30 671 981 89; E-mail: [email protected]

Abstract: To understand the pulsatility of human blood flow in vivo, it is necessary to separately investigate (1) steady shear and oscillatory flow, and (2) the superposition of steady shear flow on oscillatory flow performed under in vitro conditions. In this study a variable steady shear rate was superimposed in parallel on oscillatory shear at a constant frequency (0.5 Hz) for human blood (45% hematocrit), and an aqueous polyacrylamide polymer solution (AP 30E, concentration 300 ppm). The effect of superposition of the above two shear flows on the viscoelasticity of blood was more pronounced for the elastic (η”) than for the viscous (η’) component of viscoelasticity. With increasing superimposed shear rate, both η’ and η” decreased, especially at the low shear region. This behavior can be explained by the viscoelastic properties of blood and the phenomena of blood aggregation and disaggregation. Quantitatively, the dependence of the viscous component of complex viscosity on superimposed shear for both blood and polymer solution is described by a modified Carreau equation. The elastic component of complex viscosity decreased exponentially with increasing superimposed shear, and it is described by an exponential model.

Keywords: Blood, superposition, viscoelasticity, polyacrylamide, blood-like model fluid

DOI: 10.3233/BIR-1997-34102

Journal: Biorheology, vol. 34, no. 1, pp. 19-36, 1997