Affiliations: [a] Department of Mechanical Engineering and Mechanics, Drexel University, Philadelphia, PA 19104, USA | [b] Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109, USA
Abstract: This study describes the in vivo measurement of pressure drop and flow during the cardiac cycle in the femoral artery of a dog, and the computer simulation of the experiment based on the use of the measured flow, vessel dimensions and blood viscosity. In view of the experimental uncertainty in obtaining the accurate velocity profile at the wall region, the velocity pulse at the center was measured and numerical calculations were performed for the center line instantaneous velocity and within the two limits of spatial distribution of inlet flow conditions: uniform and parabolic. Temporal and spatial variations of flow parameters, i.e., velocity profile, shear rate, non-Newtonian viscosity, wall shear stress, and pressure drop were calculated. There existed both positive and negative shear rates during a pulse cycle, i.e., the arterial wall experiences zero shear three times during a cardiac cycle. For the parabolic inlet condition, the taper of the artery not only increased the magnitude of the positive and negative shear rates, but caused a steep gradient in shear rate, a phenomenon which in turn affects wall shear stress and pressure. In contrast, for the uniform inlet condition, the flow through the tapered artery was predominantly the developing type, which resulted in reduction in magnitude of wall shear rate along the axial direction.
Keywords: In vivo, non-Newtonian viscosity, velocity profile, shear rate, shear stress, pressure drop
DOI: 10.3233/BIR-1995-32610
Journal: Biorheology, vol. 32, no. 6, pp. 655-684, 1995
