Affiliations: Unité 14 de Physio-pathologie Respiratoire, Institut National de la Santé et de la Recherche Médicale, 54500 Vandoeuvre-les-Nancy, France
Note: [1] Address for reprint request: Unité 14 INSERM de Physiopathologie Respiratoire, C.O. n°10, 54511 Vandoeuvre-les-Nancy cedex, France.
Note: [] Accepted by: Editor J.-F. Stoltz
Abstract: Lung pressure-volume hysteresis of cat lungs has been found by Hildebrandt (J. Appl. Physiol. 28, 365–372, 1970) to be 20–50% larger than predicted from stress adaptation data on the basis of a viscoelastic model. We have reinvestigated this phenomenon in isolated rat lungs with a different approach, in which the approximation inherent to using a model is avoided Lung transfer function was derived from the digitally-computed Laplace transform of the pressure decay following a step volume change and used to predict lung pressure-flow relationship in the frequency domain. The latter was expressed in terms of lung effective resistance (Rlc) and effective elastance (Elc), and compared to the observed values (Rl and El) in the frequency range 0.01–0.5 Hz. The measurements were made in 5 lungs at a transpulmonary pressure (Pl) of 0.5 kPa and in 5 others at a Pl of 0.8 kPa. Rl was found to be 23–41% larger than Rlc at Pl=0.5 and 29–51% larger at Pl=0.8. El did not differ significantly from Elc at Pl=0.5 but was 14–28% larger at Pl=0.8. These results are in good agreement with previous findings. The differences between Rl and Rlc are proportional to the reciprocal of frequency and, thus, correspond to a rate-independent dissipation. They are consistent with a yield stress of 3–6 Pa.
